EXPLORING THE HEMODYNAMIC AND POST-OPERATIVE IMPLICATIONS: A COMPARATIVE ANALYSIS OF INTRAVENOUS SEDATION WITH DEXMEDETOMIDINE VERSUS PROPOFOL IN CARDIAC SURGICAL PROCEDURES

AA LASHARI; I AHMED; MI SHAHZAD; M TAYYAB; M OMAIR; MA RANA

doi:10.54112/bcsrj.v2023i1.566

Authors

AA LASHARI Department of Anesthesia, Bahria Town International Hospital Lahore, Pakistan
I AHMED Department of Anesthesia, Bahria Town International Hospital Lahore, Pakistan
MI SHAHZAD Department of Cardiac Anaesthesia and Intensive Care, Southampton General Hospital University Hospital Southampton NHS Foundation Trust, UK
M TAYYAB Department of Anesthesia, Bahria Town International Hospital Lahore, Pakistan
M OMAIR Department of Anesthesia, Bahria Town International Hospital Lahore, Pakistan
MA RANA Amna Inayat Medical College/ Department of Critical Care Medicine Bahria Hospital Lahore, Pakistan

DOI:

https://doi.org/10.54112/bcsrj.v2023i1.566

Keywords:

Dexmedetomidine, Propofol, Cardiac surgery, Hemodynamics, Post-operative outcomes, Delirium, Intensive Care Unit, Anesthesia

Abstract

A comparative study was conducted to examine the impact of dexmedetomidine and propofol on hemodynamic stability and post-operative outcomes in cardiac surgery patients. The study included 100 patients aged 15-60 who were ASA physical Status I-III and scheduled for elective open-heart surgery. Patients were divided into the dexmedetomidine group (n=50) and the propofol group (n=50). The study meticulously detailed hemodynamic assessments, induction protocols, and anesthesia management. The study found that dexmedetomidine exhibited consistently lower heart rates at critical intervals. In the post-operative phase, dexmedetomidine showed favorable outcomes, including significantly shorter ventilation duration (6.43 ± 8.86 vs. 8.86 ± 5.60 hours, P = 0.014) and ICU stay (92.34 ± 56.71 vs. 118.56 ± 41.89 hours, P = 0.01). The incidence of delirium was also significantly lower in the dexmedetomidine group (8% vs. 24%, P = 0.029), suggesting potential neuroprotective effects. It is important to note that the study's sample size was moderate and focused on short-term outcomes. Therefore, further research is needed to explore diverse patient subgroups and the long-term implications of dexmedetomidine and propofol in cardiac surgery anesthesia. Nonetheless, the study concluded that dexmedetomidine demonstrated favorable hemodynamic stability and beneficial post-operative outcomes, making it a promising option for cardiac surgery patients

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