EFFECTS OF VITAMIN C AND E ON LIPID PROFILE AND KIDNEY PERFORMANCE OF ALBINO RATS

S Noor; S Hayat; M Hussain; S Mahmood; S Pervaiz; S Hanif; MA Rana

doi:10.54112/bcsrj.v2022i1.87

Authors

S Noor Institute of Molecular Biology & Biotechnology, University of Lahore, Lahore, Pakistan
S Hayat Institute of Molecular Biology & Biotechnology, University of Lahore, Lahore, Pakistan
M Hussain Institute of Molecular Biology & Biotechnology, University of Lahore, Lahore, Pakistan
S Mahmood Fisheries Research and Training Institute Manawan, Lahore – Pakistan
S Pervaiz Environment Protection Department, Punjab-Pakistan
S Hanif Emergency Department, Bahria Town International Hospital Lahore-Pakistan
MA Rana ICU, Bahria Town International Hospital Lahore-Pakistan

DOI:

https://doi.org/10.54112/bcsrj.v2022i1.87

Keywords:

Vitamin, Albino Rats, higher density lipoprotein, , low density lipoprotein, cholesterol

Abstract

The current study has been intended to estimate the belongings of vitamins E and C on lipid profile and renal performance of Albino rats. Vitamin E is a chain breaking lipid dissolvable cancer prevention agent that has been utilized in the therapy of cardiovascular illnesses, immunological and hematological issues and peripheral neuropathy. Vitamin C is enormous in imperative metabolic exercises including tryptophan digestion, iron retention, development of ferritin as cell cancer prevention agent, electron transport framework and coenzyme for cathepsin, liver esterases and omega-oxidation of unsaturated fats. Vitamin C and E are known to be powerful antioxidant, utilization of vitamin C and E indicated significantly lowered hypertension and improved insulin activity and decline lipid profile. Both vitamin C and vitamin E decreased lipid per oxidation. Experiment was conducted on Albino rats and treated with different doses of vitamins according to the protocol. Albino rats were divided into 4 groups, out of four group one group called the control group and other 3 groups were treated groups, treated group A was supplemented with vitamin C, treated group B was supplemented with vitamin E), treated group C was supplemented with both vitamins together and fourth group (Group D) called the control group this group was given free access to food and water throughout the experiment. After completion of experimental period, rats were sacrificed for the collection of blood and blood was taken in EDTA for the collection of serum. Serum was collected for the analysis of higher density lipoprotein test (HDL), low density lipoprotein (LDL), very low-density lipoproteins test (VLDL), total cholesterol test (TG), meanwhile Urea test, Uric acid test and Creatinine test were examined. Result showed that means values of initial body weight and final body weight were significantly (p≤0.05) different. Values of liver, kidney, Pancreas and Heart weight (g) of Albino rats were significantly (p≤0.05) different. Values of Urea, Uric acid and Creatinine of Albino rats were significantly (p≤0.05) different. Values of lipid profile of Albino rats were significantly (p≤0.05) different.

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