PREDICTIVE VALUE OF TIMI SCORE IN PATIENTS WITH NON-ST ELEVATION MYOCARDIAL INFARCTION

Authors

  • Q ALI Department of Cardiology, Punjab Institute of Cardiology (PIC) Lahore, Pakistan
  • L ALI 2Department of Cardiology, Nishter Medical University and Hospital (NMU & H) Multan, Pakistan
  • MSK KHATTAK 2Department of Cardiology, Nishter Medical University and Hospital (NMU & H) Multan, Pakistan
  • NA SHAHID Department of Cardiology, Punjab Institute of Cardiology (PIC) Lahore, Pakistan

DOI:

https://doi.org/10.54112/bcsrj.v2023i1.516

Keywords:

Acute Coronary Syndrome, Non-ST Elevation Myocardial Infarction, TIMI risk score, Prognosis

Abstract

This retrospective study was conducted in the Department of Cardiology in tertiary care hospitals during June 2022 and June 2023 to evaluate the power of TIMI risk score in predicting 14-day mortality in patients with NSTEMI presenting in the cardiac center of a local hospital for determining prognostic value to the score in our cohort. The study included 250 patients aged > 18 years presenting with NSTEMI. A proforma was used to collect data, including demographic data, baseline investigations, detailed history, TIMI score at the time of presentation, and patient status after 14 days of hospital stay. All patients followed ACS protocol, and NSTEMI was managed according to current guidelines. Results showed that the predictive value of the TIMI score, AUC,  was 0.788 (95% CI: .688-.886), its sensitivity was 77.80%, and its specificity was 68.08%. In subjects with a TIMI score ≥4 (11.2%, n=12/105), the 14-day mortality rate was more significant than those with a TIMI score <4 (3.4%, n=5/145) (P<0.001). Multivariate analysis reveal that TIMI risk and cardiac arrest were independent predictors of 14-day mortality. TIMI risk score is a simple and useful tool for risk stratification in NSTEMI patients. Its use will enable clinicians to adopt precise and strategic interventions for these patients.

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References

Anbr, A. F., Farag, E. M., Roshdy, H. S., Gad, M. M., ALMaashani, S. M., and Sayed, A. S. (2023). Usefulness of layer specific speckle tracking 2-dimensional echocardiography as a risk stratifying tool in non ST elevation-acute coronary syndrome. Zagazig University Medical Journal 29, 104-112.

Bashiruddin, A., Chowdhury, M. I., Bhattacharjee, B., Shahin, A. H., Ahsan, S. A., Mandal, M., Dhar, S., Mahmud, I., and Hossain, M. S. (2019). Association of Thrombolysis in Myocardial Infarction (TIMI) Risk Score with Angiographic Severity of Coronary Artery Disease In Patients with Non-ST Elevation Acute Coronary Syndrome. University Heart Journal 15, 68-73.

Collet, J.-P., and Thiele, H. (2021). Management of acute coronary syndromes in patients presenting without persistent ST-segment elevation and coexistent atrial fibrillation–Dual versus triple antithrombotic therapy. European heart journal 42, 2020-2021.

Keykhaei, M., Ashraf, H., Rashedi, S., Farrokhpour, H., Heidari, B., Zokaei, S., Bagheri, S., Foroumadi, R., Asgarian, S., and Amirian, A. (2021). Differences in the 2020 ESC versus 2015 ESC and 2014 ACC/AHA guidelines on the management of acute coronary syndromes in patients presenting without persistent ST-segment elevation. Current Atherosclerosis Reports 23, 1-11.

Khan, S. (2019). Situation analysis of health care system of Pakistan: post 18 amendments. Health Care Current Reviews 7, 244.

Meo, S. A., Zia, I., Bukhari, I. A., and Arain, S. A. (2016). Type 2 diabetes mellitus in Pakistan: Current prevalence and future forecast. JPMA. The Journal of the Pakistan Medical Association 66, 1637-1642.

Naghavi, M. (2019). Global, regional, and national burden of suicide mortality 1990 to 2016: systematic analysis for the Global Burden of Disease Study 2016. bmj 364.

Pollack, C. V., Amin, A., Wang, T., Deitelzweig, S., Cohen, M., Slattery, D., Fanikos, J., DiLascia, C., Tuder, R., and Kaatz, S. (2020). Contemporary NSTEMI management: the role of the hospitalist. Hospital practice 48, 1-11.

Ralapanawa, U., and Sivakanesan, R. (2021). Epidemiology and the magnitude of coronary artery disease and acute coronary syndrome: a narrative review. Journal of epidemiology and global health 11, 169.

Ramos, J., and Wolek, H. (2023). Chest Pain: Evaluation and Management. Physician Assistant Clinics 8, 1-16.

Ryu, K. S., Bae, J.-W., Jeong, M. H., Cho, M.-C., Ryu, K.-H., and Investigators, K. A. M. I. R. (2019). Risk scoring system for prognosis estimation of multivessel disease among patients with ST-segment elevation myocardial infarction. International heart journal 60, 708-714.

Shabana, Shahid, S. U., and Sarwar, S. (2020). The abnormal lipid profile in obesity and coronary heart disease (CHD) in Pakistani subjects. Lipids in health and disease 19, 1-7.

Tyler, J. M., Brown, C., Jentzer, J. C., Baran, D. A., van Diepen, S., Kapur, N. K., Garberich, R. F., Garcia, S., Sharkey, S. W., and Henry, T. D. (2022). Variability in reporting of key outcome predictors in acute myocardial infarction cardiogenic shock trials. Catheterization and Cardiovascular Interventions 99, 19-26.

Yang, B., Bai, L., Zhang, Y., Cheng, Y., Zhao, C., Huang, B., and Chen, M. (2022). The Value of Different Short-Term Risk Scoring Models in Predicting Long-Term Death of Acute Myocardial Infarction. Journal of Clinical Medicine 11, 5054.

Zafrir, B., Adawi, S., Khalaily, M., Jaffe, R., Eitan, A., Barnett‐Griness, O., and Saliba, W. (2019). Long‐Term Risk Stratification of Patients Undergoing Coronary Angiography According to the Thrombolysis in Myocardial Infarction Risk Score for Secondary Prevention. Journal of the American Heart Association 8, e012433.

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Published

2023-11-04

How to Cite

ALI, Q., ALI, L., KHATTAK, M., & SHAHID, N. (2023). PREDICTIVE VALUE OF TIMI SCORE IN PATIENTS WITH NON-ST ELEVATION MYOCARDIAL INFARCTION. Biological and Clinical Sciences Research Journal, 2023(1), 516. https://doi.org/10.54112/bcsrj.v2023i1.516

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