CROSS-SECTIONAL ASSESSMENT OF HEMATOLOGICAL AND BIOCHEMICAL PROFILES IN HELICOBACTER PYLORI-POSITIVE INDIVIDUALS

Authors

  • AU REHMAN Department of Health and Biological Sciences, Abasyn University, Peshawar, Pakistan
  • K KHAN Department of Health and Biological Sciences, Abasyn University, Peshawar, Pakistan
  • I ULHAQ Department of Health and Biological Sciences, Abasyn University, Peshawar, Pakistan
  • S NOOR Pakistan Institute of Medical and Management Sciences, Warsak Road, Peshawar, Pakistan
  • A ALI 3Department of Centre for Omic Sciences, Islamia College, Peshawar, Pakistan
  • U ULLAH Department of Health and Biological Sciences, Abasyn University, Peshawar, Pakistan
  • MF RAHEEM Department of Health and Biological Sciences, Abasyn University, Peshawar, Pakistan
  • A HAQ Department of Health and Biological Sciences, Abasyn University, Peshawar, Pakistan

DOI:

https://doi.org/10.54112/bcsrj.v2024i1.876

Keywords:

Helicobacter pylori, Vitamin D, Complete blood count

Abstract

Helicobacter pylori (H. pylori) infection is a prevalent condition known to affect various hematological and biochemical parameters. Understanding its prevalence and associated blood parameter alterations can provide valuable insights into its clinical implications. Objective: To determine the prevalence of H. pylori infection in District Peshawar KP and its association with complete blood count (CBC) and biochemical parameters to establish a clear relationship between H. pylori infection and these variables. Methods: A longitudinal investigation involved 300 individuals from District Peshawar KP. Blood samples were collected from positive and negative participants for H. pylori infection. These samples were analyzed for various hematological and biochemical parameters, including red blood cell (RBC) count, hemoglobin (Hb) concentration, mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCH), mean corpuscular hemoglobin concentration (MCHC), white blood cell (WBC) count, platelet count (PLT), vitamin D levels, urea, and serum glutamic-pyruvic transaminase (SGPT/ALT) levels. Statistical analysis was performed to identify significant associations. Results: The prevalence of H. pylori infection was 57.7% (n=173), with 42.3% (n=122) testing negative. Gender distribution showed 39.7% males (n=119) and 60.3% females (n=181). Age distribution included 17.3% (n=52) aged 2-20 years, 48.5% (n=146) aged 21-40 years, 28.3% (n=85) aged 41-60 years, 5% (n=15) aged 61-80 years, and 0.7% (n=2) over 80 years. Hematological parameters were as follows: RBC count 4 ± 3.1 × 10^6/µL, Hb concentration 13.4 ± 1.64 g/dL, MCV 81 ± 7.8 fL, MCH 27 ± 3.8 pg, MCHC 33.9 ± 24.9 g/dL, WBC count 10 ± 12 × 10^3/µL, and PLT count 30 ± 83 × 10^3/µL. Significant relationships (p < 0.05) were observed between H. pylori infection and alterations in these blood parameters. Vitamin D levels averaged 39 ± 21, and ALT levels were significantly higher in H. pylori-positive cases (32.7 ± 14). Conclusion: This study demonstrates a significant prevalence of H. pylori infection in District Peshawar KP and its association with various hematological and biochemical parameters. The findings suggest that H. pylori infection may have notable effects on blood parameters, highlighting the need for further research to understand the clinical implications and to guide future studies in this area.

Downloads

Download data is not yet available.

References

Lu, J., et al., Negative-high titer of Helicobacter pylori antibody and lipid profiles. BioMed Research International, 2022. 2022.

Paes Dutra, J.A., et al., Microparticles and nanoparticles-based approaches to improve oral treatment of Helicobacter pylori infection. Critical Reviews in Microbiology, 2023: p. 1-22.

Gendi, R.R.J.S.J.o.O.U., Biochemical Changes Associated with Helicobacter pylori Infection. 2016. 3(2): p. 8-12.

Elnemr, G.M.J.T.E.J.o.H.M., Prevalence of Helicobacter Pylori Infection in Anemic and Non-anemic Children in Helwan, Egypt: Impact on Blood Cell Parameters. 2016. 64(1): p. 267-276.

Papagiannakis, P., et al., The role of Helicobacter pylori infection in hematological disorders. 2013. 24(8): p. 685-690.

Gupta, A., et al., Treatment of H. pylori infection and gastric ulcer: Need for novel Pharmaceutical formulation. Heliyon, 2023. 9(10).

Hooi, J.K., et al., Global prevalence of Helicobacter pylori infection: systematic review and meta-analysis. Gastroenterology, 2017. 153(2): p. 420-429.

Eledo, B.O., et al., Evaluation of Some Haematological Parameters Among Helicobacter pylori infected students in a Nigerian tertiary educational institution. 2018. 4(1): p. 34-39.

Samy, W., et al., Prevalence of Helicobacter Pylori Infection and its Correlation with Complete Blood Count Parameters in Adult Males at Taif City, Saudi Arabia. SAS J. Med, 2016. 2(3): p. 49-54.

Mwafy, S.N., W.M.J.H. Afana, transfusion, and c. therapy, Hematological parameters, serum iron and vitamin B 12 levels in hospitalized Palestinian adult patients infected with Helicobacter pylori: a case–control study. 2018. 40: p. 160-165.

Abd El-Maksoud, H., K. Fararh, and M.J.B.V.M.J. Metwaly, Biochemical changes associated with helicobacter pylori infection. 2016. 1: p. 103-109.

Kaptan, K., et al., Helicobacter pylori—is it a novel causative agent in vitamin B12 deficiency? Archives of Internal Medicine, 2000. 160(9): p. 1349-1353.

Rahman, Y.A., et al., Helicobacter pylori and its hematological effect. 2019. 31: p. 332-342.

Khovidhunkit, W., F.S. Greenspan, and J.C. Jaume, Development of overt autoimmune hyperthyroidism in a patient therapeutically immunosuppressed after liver transplantation. Thyroid, 2000. 10(9): p. 829-832.

Khovidhunkit, W., et al., Effects of infection and inflammation on lipid and lipoprotein metabolism: mechanisms and consequences to the host. The Journal of Lipid Research, 2004. 45(7): p. 1169-1196.

Chen, L.-K., et al., Association of insulin resistance and hematologic parameters: study of a middle-aged and elderly Chinese population in Taiwan. Journal of the Chinese Medical Association, 2006. 69(6): p. 248-253.

Charles, L.E., et al., Obesity, white blood cell counts, and platelet counts among police officers. Obesity, 2007. 15(11): p. 2846-2854.

Jafarzadeh, A., et al., Total leukocyte counts and neutrophil-lymphocyte count ratios among Helicobacter pylori-infected patients with peptic ulcers: independent of bacterial CagA status. Southeast Asian Journal of Tropical Medicine & Public Health, 2013. 44(1): p. 82-88.

Thorsen, S.U., et al., 25-Hydroxyvitamin D and peripheral immune mediators: results from two Nationwide Danish Pediatric Cohorts. Nutrients, 2017. 9(4): p. 365.

Yang, L., et al., Effect of vitamin D on Helicobacter pylori infection and eradication: A meta‐analysis. Helicobacter, 2019. 24(5): p. e12655.

Wang, J., et al., Correlations of 25 (OH) D level with blood lipid, inflammatory factors and vascular endothelial function in diabetic patients. Eur Rev Med Pharmacol Sci, 2018. 22(3): p. 731-735.

Ponda, M.P., et al., Vitamin D may not improve lipid levels: a serial clinical laboratory data study. Circulation, 2012. 126(3): p. 270-277.

Sharma, P.K., et al., Atrophic gastritis with high prevalence of Helicobacter pylori is a predominant feature in patients with dyspepsia in a high altitude area. Tropical Gastroenterology, 2015. 35(4): p. 246-251.

Downloads

Published

2024-06-25

How to Cite

REHMAN, . A., KHAN, K., ULHAQ, I., NOOR, S., ALI, A., ULLAH, . U., RAHEEM, M., & HAQ, A. (2024). CROSS-SECTIONAL ASSESSMENT OF HEMATOLOGICAL AND BIOCHEMICAL PROFILES IN HELICOBACTER PYLORI-POSITIVE INDIVIDUALS. Biological and Clinical Sciences Research Journal, 2024(1), 876. https://doi.org/10.54112/bcsrj.v2024i1.876

Most read articles by the same author(s)

1 2 3 4 > >>