ADAPTOGENIC EFFECTS OF PANAX GINSENG PLANT EXTRACT ON IMMUNE MODULATION IN LAYERS AGAINST SALMONELLA ENTERITIDIS

Authors

  • M TAIMOOR Veterinary Research Institute, Zarrar Shaheed Road, Lahore Cantt 54810, Pakistan
  • H NOOR Veterinary Research Institute, Zarrar Shaheed Road, Lahore Cantt 54810, Pakistan
  • S YASMIN Veterinary Research Institute, Zarrar Shaheed Road, Lahore Cantt 54810, Pakistan
  • M USMAN Department of Poultry Science, University of Agriculture Faisalabad, sub campus Toba Tek Singh, Pakistan
  • D ASHRAF University of Agriculture, Faisalabad Pakistan
  • D HUSSAIN Faculty of Veterinary Sciences, University of Layyah, Layyah, Pakistan
  • S IQBAL Faculty of Veterinary Sciences, University of Agriculture, Faisalabad Pakistan
  • W HASAN Department of Clinical Medicine and Surgery, University of Agriculture Faisalabad Pakistan
  • N ZAFAR University of Veterinary and Animal Sciences Lahore sub campus jhang, Pakistan
  • R AJAZ Universitas Indonesia(UI), Jakarta, Indonesia

DOI:

https://doi.org/10.54112/bcsrj.v2024i1.806

Keywords:

adaptogenic, Panax ginseng, infectious diseases, Salmonella Enteritidis, antibodies

Abstract

Panax ginseng, a traditional medicinal herb known for its adaptogenic properties, has garnered significant attention for its potential role in immune modulation and disease prevention. In this study, we investigate the adaptogenic effects of Panax ginseng on immune modulation in layers against Salmonella Enteritidis.  This randomized control trial was conducted at the University of Agriculture, Faisalabad, from January 2023 to October 2023. A total of 450 laying hens were included in this study. The laying hens were randomly assigned to different experimental groups to ensure unbiased representation and minimize confounding variables. The laying hens were separated into several experimental groups, including a benchmark group and one or more treatment groups receiving Panax ginseng supplementation. A total of 450 laying hens were included in the study, divided into five experimental groups: a control group (n = 90) and four treatment groups receiving varying doses of Panax ginseng supplementation (n = 90 each). Compared to the control group, hens receiving low, medium, and high portions of ginseng displayed elevated degrees of IgG and IgM antibodies. Specifically, the high-portion ginseng group demonstrated the most noteworthy mean values for both IgG (75 ± 18) and IgM (50 ± 12), indicating a vigorous invulnerable reaction. It is concluded that supplementation with Panax ginseng holds promise as a natural intervention for enhancing immune modulation and reducing pathogen load in laying hens challenged with Salmonella Enteritidis. Ginseng may serve as a valuable adjunct therapy in poultry production to mitigate infectious diseases and improve overall health outcomes.

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References

Tang, Y., Jones, M., Barrow, P. A., & Foster, N. (2020). Immune modulation and the development of fowl typhoid: a model of human disease?. Pathogens, 9(10), 843., https://doi.org/10.3390/pathogens9100843.

Bravo-Blas, A., Utriainen, L., Clay, S. L., Kästele, V., Cerovic, V., Cunningham, A. F., ... & Milling, S. W. (2019). Salmonella enterica serovar typhimurium travels to mesenteric lymph nodes both with host cells and autonomously. The Journal of Immunology, 202(1), 260-267.

Meijerink, N., Van den Biggelaar, R. H., Van Haarlem, D. A., Stegeman, J. A., Rutten, V. P., & Jansen, C. A. (2021). A detailed analysis of innate and adaptive immune responsiveness upon infection with Salmonella enterica serotype Enteritidis in young broiler chickens. Veterinary Research, 52, 1-21. https://doi.org/10.1186/s13567-021-00978-y

Sutton, K. M., Morris, K. M., Borowska, D., Sang, H., Kaiser, P., Balic, A., & Vervelde, L. (2021). Characterization of conventional dendritic cells and macrophages in the spleen using the CSF1R-reporter transgenic chickens. Frontiers in Immunology, 12, 636436.

Sun, Y., Chen, S., Wei, R., Xie, X., Wang, C., Fan, S., ... & Wang, X. (2018). Metabolome and gut microbiota variation with long-term intake of Panax ginseng extracts on rats. Food & function, 9(6), 3547-3556.

Liu, X. Y., Xiao, Y. K., Hwang, E., Haeng, J. J., & Yi, T. H. (2019). Antiphotoaging and Antimelanogenesis Properties of Ginsenoside C‐Y, a Ginsenoside Rb2 Metabolite from American Ginseng PDD‐ginsenoside. Photochemistry and Photobiology, 95(6), 1412-1423.

Lee, W. J., Kim, Y. S., & Shim, W. S. (2018). Korean Red Ginseng extract and ginsenoside Rg3 have anti-pruritic effects on chloroquine-induced itch by inhibition of MrgprA3/TRPA1-mediated pathway. Journal of Ginseng Research, 42(4), 470-475.

Jang, M., Lee, M. J., Choi, J. H., Kim, E. J., Nah, S. Y., Kim, H. J., ... & Cho, I. H. (2016). Ginsenoside Rb1 attenuates acute inflammatory nociception by inhibition of neuronal ERK phosphorylation by regulation of the Nrf2 and NF-κB pathways. The Journal of Pain, 17(3), 282-297.

Wright, S. M., & Altman, E. (2020). Inhibition of herpes simplex viruses, types 1 and 2, by ginsenoside 20 (S)-Rg3. Journal of Microbiology and Biotechnology, 30(1), 101.

Mei, Y., Fang, C., Ding, S., Liu, X., Hu, J., Xu, J., & Mei, Q. (2019). PAP-1 ameliorates DSS-induced colitis with involvement of NLRP3 inflammasome pathway. International Immunopharmacology, 75, 105776.

Ratan, Z. A., Youn, S. H., Kwak, Y. S., Han, C. K., Haidere, M. F., Kim, J. K., ... & Cho, J. Y. (2021). Adaptogenic effects of Panax ginseng on modulation of immune functions. Journal of ginseng research, 45(1), 32-40. https://doi.org/10.1016/j.jgr.2020.09.004.

Panossian, A. (2017). Understanding adaptogenic activity: specificity of the pharmacological action of adaptogens and other phytochemicals. Annals of the New York Academy of Sciences, 1401(1), 49-64.

Kim, J. H., Yi, Y. S., Kim, M. Y., & Cho, J. Y. (2017). Role of ginsenosides, the main active components of Panax ginseng, in inflammatory responses and diseases. Journal of ginseng research, 41(4), 435-443.

Zhou, Y., Yang, Z., Gao, L., Liu, W., Liu, R., Zhao, J., & You, J. (2017). Changes in element accumulation, phenolic metabolism, and antioxidative enzyme activities in the red-skin roots of Panax ginseng. Journal of ginseng research, 41(3), 307-315.

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Published

2024-04-24

How to Cite

TAIMOOR, M., NOOR, H., YASMIN, S., USMAN, M., ASHRAF, D., HUSSAIN, D., IQBAL, S., HASAN, W., ZAFAR, N., & AJAZ, R. (2024). ADAPTOGENIC EFFECTS OF PANAX GINSENG PLANT EXTRACT ON IMMUNE MODULATION IN LAYERS AGAINST SALMONELLA ENTERITIDIS. Biological and Clinical Sciences Research Journal, 2024(1), 806. https://doi.org/10.54112/bcsrj.v2024i1.806

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