ANTIBIOTIC PRESCRIPTION AND ANTIMICROBIAL RESISTANCE RATES OF UROPATHOGENS IN CHILDREN WITH URINARY TRACT INFECTIONS

Authors

  • M ADNAN Department of Urology, Bakhtawar Amin Trust Teaching Hospital Multan, Pakistan
  • . SAIFULLAH Department of Urology, Bakhtawar Amin Trust Teaching Hospital Multan, Pakistan
  • MAH KHAN Department of Urology, Bakhtawar Amin Trust Teaching Hospital Multan, Pakistan
  • M HUSSAIN Department of Urology, Sharif Medical and Dental College Lahore, Pakistan
  • F HAMAYUN Department of Pediatrics Urology, The Children's Hospital & Institute of Child Health Lahore, Pakistan
  • G KHAN Department of Urology, Gomal Medical College Dera Ismail Khan, Pakistan

DOI:

https://doi.org/10.54112/bcsrj.v2023i1.263

Keywords:

Antibiotics, Antimicrobial Resistance, Pathogens, Urinary Tract Infections

Abstract

The current study aimed to evaluate the antibiotic treatment of UTIs and antimicrobial resistance of uropathogens in children with UTIs. A retrospective study was conducted in the Pediatrics Department of different centers from November 2021-November 2022. A total of 100 children with febrile or afebrile urinary tract infections were included in the study. UTIs were categorized as febrile and afebrile. Antibiotics were prescribed according to the UTI and pathogen identified. E.coli was the most common pathogen (80%) found in patients of both groups, while Citrobacter sp and gram-positive cocci were only found in one case each. Amikacin was mostly prescribed in both groups (54 for fUTIs and 8 for aUTIs). 60% of the E.coli isolates were resistant to ampicillin, 10% to AMC (amoxicillin and clavulanic acid), and 15% to SAM (Sulfacetamide sodium). The highest resistant rates of E.coli were observed against SXT, i.e., 25%. Based on the results, it can be concluded that there is a need for antimicrobial resistance stewardship programs to control the increasing prevalence of resistance among UTI-causing pathogens.

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References

A‘t Hoen, L., Bogaert, G., Radmayr, C., Dogan, H. S., Nijman, R. J., Quaedackers, J., Rawashdeh, Y. F., Silay, M. S., Tekgul, S., and Bhatt, N. R. (2021). Update of the EAU/ESPU guidelines on urinary tract infections in children. Journal of Pediatric Urology 17, 200-207.

Amin, O., Prestel, C., Gonzalez, M. D., Lyon, T., Shane, A., Jaggi, P., Tippett, A., and Yildirim, I. (2020). Urinary tract infections with extended-spectrum-β-lactamase-producing Bacteria: case-control study. The Pediatric infectious disease journal 39, 211-216.

Bryce, A., Costelloe, C., Wootton, M., Butler, C. C., and Hay, A. D. (2018). Comparison of risk factors for, and prevalence of, antibiotic resistance in contaminating and pathogenic urinary Escherichia coli in children in primary care: prospective cohort study. Journal of Antimicrobial Chemotherapy 73, 1359-1367.

Bryce, A., Hay, A. D., Lane, I. F., Thornton, H. V., Wootton, M., and Costelloe, C. (2016). Global prevalence of antibiotic resistance in paediatric urinary tract infections caused by Escherichia coli and association with routine use of antibiotics in primary care: systematic review and meta-analysis. bmj 352.

Bullens, M., de Cerqueira Melo, A., Raziq, S., Lee, J., Khalid, G., Khan, S., Zada, A., Wailly, Y., Zeshan, S., and Saad, N. (2022). Antibiotic resistance in patients with urinary tract infections in Pakistan. Public Health Action 12, 48-52.

Chardavoyne, P. C., and Kasmire, K. E. (2020). Appropriateness of antibiotic prescriptions for urinary tract infections. Western Journal of Emergency Medicine 21, 633.

De Lorenzis, E., Alba, A. B., Cepeda, M., Galan, J. A., Geavlete, P., Giannakopoulos, S., Saltirov, I., Sarica, K., Skolarikos, A., and Stavridis, S. (2020). Bacterial spectrum and antibiotic resistance of urinary tract infections in patients treated for upper urinary tract calculi: a multicenter analysis. European Journal of Clinical Microbiology & Infectious Diseases 39, 1971-1981.

Karam, M. R. A., Habibi, M., and Bouzari, S. (2019). Urinary tract infection: Pathogenicity, antibiotic resistance and development of effective vaccines against Uropathogenic Escherichia coli. Molecular immunology 108, 56-67.

Kayastha, K., Dhungel, B., Karki, S., Adhikari, B., Banjara, M. R., Rijal, K. R., and Ghimire, P. (2020). Extended-spectrum β-lactamase-producing Escherichia coli and Klebsiella species in pediatric patients visiting International Friendship Children’s Hospital, Kathmandu, Nepal. Infectious Diseases: Research and Treatment 13, 1178633720909798.

Kot, B. (2019). Antibiotic Resistance Among Uropathogenic. Polish journal of microbiology 68, 403-415.

Pérez, R. P., Ortega, M. J. C., Álvarez, J. A., Baquero-Artigao, F., Rico, J. C. S., Zúñiga, R. V., Campos, L. M., Gallego, B. C., Fernández, A. J. C., and Calvo, C. (2019). Recommendations on the diagnosis and treatment of urinary tract infection. Anales de Pediatría (English Edition) 90, 400. e1-400. e9.

Sehested, L. T., Kamperis, K., Winding, L., Bjerre, C. K., Neland, M., Hagstrøm, S., Wilms, L. K., Andersen, M. L. E., Kuhne‐Qvist, L., and Hoffmann‐Petersen, J. S. (2021). Children with acute pyelonephritis need medical re‐evaluation when home‐treated with oral antibiotics. Acta Paediatrica 110, 2627-2634.

Seo, E. Y., Cho, S. M., Lee, D. S., Choi, S. M., Kim, D. K., Seo, E. Y., Cho, S. M., Lee, D. S., Choi, S. M., and Kim, D. K. (2017). Clinical study of prevalence of antibiotic resistance of Escherichia coli in urinary tract infection in children: a 9-year retrospective, single center experience. Childhood Kidney Diseases 21, 121-127.

Tullus, K., and Shaikh, N. (2020). Urinary tract infections in children. The Lancet 395, 1659-1668.

Yilmaz, Y., Tazegun, Z. T., Aydin, E., and Dulger, M. (2016). Bacterial uropathogens causing urinary tract infection and their resistance patterns among children in Turkey. Iranian Red Crescent Medical Journal 18.

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Published

2023-05-08

How to Cite

ADNAN, M., SAIFULLAH, ., KHAN , M., HUSSAIN, M., HAMAYUN, F., & KHAN, G. (2023). ANTIBIOTIC PRESCRIPTION AND ANTIMICROBIAL RESISTANCE RATES OF UROPATHOGENS IN CHILDREN WITH URINARY TRACT INFECTIONS. Biological and Clinical Sciences Research Journal, 2023(1), 263. https://doi.org/10.54112/bcsrj.v2023i1.263

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