A STUDY ON THE EFFECT OF DIABETES MELLITUS ON THE CLINICAL OUTCOME AMONG PATIENTS WITH COVID-19
DOI:
https://doi.org/10.54112/bcsrj.v2023i1.487Keywords:
COVID-19, Diabetes, MortalityAbstract
This study aimed to investigate how diabetes mellitus affects the clinical outcomes of patients with COVID-19. The study was conducted between November 2022 and April 2023 at the Department of Medicine in Khyber Teaching Hospital, Peshawar. We included 40 diabetic COVID-19 patients and 40 non-diabetic COVID-19 patients in our research and examined the incidence of sepsis, acute respiratory distress syndrome (ARDS), and mortality. The results showed that diabetic COVID-19 patients had significantly higher mortality, sepsis, and ARDS rates than non-diabetic COVID-19 patients. Mortality was reported in 22.5% of diabetic patients compared to 5% of non-diabetic patients (P = 0.01). The incidence of sepsis was 25% among diabetic patients and 5% among non-diabetic patients (P = 0.02). Similarly, ARDS was reported in 35% of diabetic patients compared to 10% of non-diabetic patients (P = 0.007). In conclusion, our study suggests that diabetes significantly worsens clinical outcomes among patients with COVID-19.
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Abu-Farha, M., Al-Mulla, F., Thanaraj, T. A., Kavalakatt, S., Ali, H., Abdul Ghani, M., and Abubaker, J. (2020). Impact of diabetes in patients diagnosed with COVID-19. Frontiers in immunology 11, 576818.
Alshukry, A., Abbas, M. B., Ali, Y., Alahmad, B., Al-Shammari, A. A., Alhamar, G., Abu-Farha, M., AbuBaker, J., Devarajan, S., and Dashti, A. A. (2021). Clinical characteristics and outcomes of COVID-19 patients with diabetes mellitus in Kuwait. Heliyon 7.
Chan, J. F.-W., Yuan, S., Kok, K.-H., To, K. K.-W., Chu, H., Yang, J., Xing, F., Liu, J., Yip, C. C.-Y., and Poon, R. W.-S. (2020). A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person-to-person transmission: a study of a family cluster. The lancet 395, 514-523.
Chen, X., Hu, W., Ling, J., Mo, P., Zhang, Y., Jiang, Q., Ma, Z., Cao, Q., Deng, L., and Song, S. (2020). Hypertension and diabetes delay the viral clearance in COVID-19 patients. MedRxiv, 2020.03. 22.20040774.
Ciotti, M., Ciccozzi, M., Terrinoni, A., Jiang, W.-C., Wang, C.-B., and Bernardini, S. (2020). The COVID-19 pandemic. Critical reviews in clinical laboratory sciences 57, 365-388.
Dong, E., Du, H., and Gardner, L. (2020). An interactive web-based dashboard to track COVID-19 in real time. The Lancet infectious diseases 20, 533-534.
Fang, L., Karakiulakis, G., and Roth, M. (2020). Are patients with hypertension and diabetes mellitus at increased risk for COVID-19 infection? The lancet respiratory medicine 8, e21.
Giovanetti, M., Cella, E., Ivanov, I., Grigorova, L., Stoikov, I., Donchev, D., Dimitrova, R., Slavov, S. N., Mavian, C., and Fonseca, V. (2023). Genomic epidemiology and lineage dynamics of SARS-CoV-2 in Bulgaria: Insights from a three-Year pandemic analysis. Viruses 15, 1924.
Gupta, R., Ghosh, A., Singh, A. K., and Misra, A. (2020). Clinical considerations for patients with diabetes in times of COVID-19 epidemic. Diabetes & metabolic syndrome 14, 211.
Huang, D., Lian, X., Song, F., Ma, H., Lian, Z., Liang, Y., Qin, T., Chen, W., and Wang, S. (2020). Clinical features of severe patients infected with 2019 novel coronavirus: a systematic review and meta-analysis. Annals of translational medicine 8.
Li, G., Chen, Z., Lv, Z., Li, H., Chang, D., and Lu, J. (2021). Diabetes mellitus and COVID-19: associations and possible mechanisms. International Journal of Endocrinology 2021.
Lim, S., Bae, J. H., Kwon, H.-S., and Nauck, M. A. (2021). COVID-19 and diabetes mellitus: from pathophysiology to clinical management. Nature Reviews Endocrinology 17, 11-30.
Liu, G. S., Hong, L., Zhao, S. C., Lu, R. J., Niu, P. H., and Tan, W. J. (2019). Viral and bacterial etiology of acute febrile respiratory syndrome among patients in Qinghai, China. Biomedical and Environmental Sciences 32, 438-445.
Man, A. W., Li, H., and Xia, N. (2020). Impact of lifestyles (diet and exercise) on vascular health: oxidative stress and endothelial function. Oxidative medicine and cellular longevity 2020.
Marfella, R., Paolisso, P., Sardu, C., Bergamaschi, L., D’Angelo, E. C., Barbieri, M., Rizzo, M. R., Messina, V., Maggi, P., and Coppola, N. (2020). Negative impact of hyperglycaemia on tocilizumab therapy in Covid-19 patients. Diabetes & metabolism 46, 403-405.
Ng, W. H., Tipih, T., Makoah, N. A., Vermeulen, J.-G., Goedhals, D., Sempa, J. B., Burt, F. J., Taylor, A., and Mahalingam, S. (2021). Comorbidities in SARS-CoV-2 patients: a systematic review and meta-analysis. MBio 12, 10.1128/mbio. 03647-20.
Nicosia, R. F., Ligresti, G., Caporarello, N., Akilesh, S., and Ribatti, D. (2021). COVID-19 vasculopathy: mounting evidence for an indirect mechanism of endothelial injury. The American Journal of Pathology 191, 1374-1384.
Palaiodimos, L., Kokkinidis, D. G., Li, W., Karamanis, D., Ognibene, J., Arora, S., Southern, W. N., and Mantzoros, C. S. (2020). Severe obesity, increasing age and male sex are independently associated with worse in-hospital outcomes, and higher in-hospital mortality, in a cohort of patients with COVID-19 in the Bronx, New York. Metabolism 108, 154262.
Sardu, C., Gambardella, J., Morelli, M. B., Wang, X., Marfella, R., and Santulli, G. (2020). Hypertension, thrombosis, kidney failure, and diabetes: is COVID-19 an endothelial disease? A comprehensive evaluation of clinical and basic evidence. Journal of clinical medicine 9, 1417.
Shi, Q., Zhang, X., Jiang, F., Zhang, X., Hu, N., Bimu, C., Feng, J., Yan, S., Guan, Y., and Xu, D. (2020). Clinical characteristics and risk factors for mortality of COVID-19 patients with diabetes in Wuhan, China: a two-center, retrospective study. Diabetes care 43, 1382-1391.
Stawicki, S. P., Jeanmonod, R., Miller, A. C., Paladino, L., Gaieski, D. F., Yaffee, A. Q., De Wulf, A., Grover, J., Papadimos, T. J., and Bloem, C. (2020). The 2019–2020 novel coronavirus (severe acute respiratory syndrome coronavirus 2) pandemic: A joint american college of academic international medicine-world academic council of emergency medicine multidisciplinary COVID-19 working group consensus paper. Journal of global infectious diseases 12, 47.
Stoian, A. P., Banerjee, Y., Rizvi, A. A., and Rizzo, M. (2020). Diabetes and the COVID-19 pandemic: how insights from recent experience might guide future management. Metabolic syndrome and related disorders 18, 173-175.
Williamson, E. J., Walker, A. J., Bhaskaran, K., Bacon, S., Bates, C., Morton, C. E., Curtis, H. J., Mehrkar, A., Evans, D., and Inglesby, P. (2020). Factors associated with COVID-19-related death using OpenSAFELY. Nature 584, 430-436.
Wu, Z., and McGoogan, J. M. (2020). Characteristics of and important lessons from the coronavirus disease 2019 (COVID-19) outbreak in China: summary of a report of 72 314 cases from the Chinese Center for Disease Control and Prevention. jama 323, 1239-1242.
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Copyright (c) 2023 M SANNAN , MM GUL , Z NASIM , SU KHAN , A ULLAH , R NASIR
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