RESISTANCE PATTERN OF EXTENDED DRUG RESISTANT SALMONELLA TYPHI IN CHILDREN

. ANSWAR; A SALAHUDDIN; A AHMAD

doi:10.54112/bcsrj.v2023i1.450

Authors

. ANSWAR Pediatrics Deptment HMC/ KGMC, Peshawar, Pakistan
A SALAHUDDIN Pediatrics Department, Peshawar General Hospital Peshawar Pakistan
A AHMAD Pediatrics Deptment HMC/ KGMC, Peshawar, Pakistan

DOI:

https://doi.org/10.54112/bcsrj.v2023i1.450

Keywords:

Antibiotic resistance, Salmonella typhi, children, enteric fever

Abstract

Objective: To determine the frequency of antibiotic resistance of extended drug-resistant Salmonella typhi in children. Cross-sectional observational study was conducted at Pediatric B Unit, Hayatabad Medical Complex, Peshawar, from 1st April 2021 to 30th June 2022. Approval from the institutional ethical committee was obtained. Using nonprobability consecutive sampling technique, this study was conducted on 104 pediatric patients admitted to Children B Unit with blood culture-proven enteric fever. Data was collected from blood cultures and sensitivity reports from the microbiology section of our hospital laboratory. This study was conducted on 32 female and 72 male pediatric in-patients with blood culture-proven enteric fever caused by Salmonella typhi. Resistance to Azithromycin was 43.26%, Meropenem 17.30%, Polymixin 13.46%, Colistin 31.73%, Tigecycline, 01.92%, Imipenem 04.80% Salmonella typhi demonstrated high levels of resistance to commonly used antibiotics.

Downloads

Download data is not yet available.

References

Ahmad, A., Mustaan, S., Wahab, F., Ayyaz, M., Sadiq, A., & Hussain, I. (2021). Pattern of Antibiotic Resistance in Salmonella Typhi Isolates with Special Consideration to Extended Drug Resistant Typhoid. Journal of Saidu Medical College, Swat, 11(2), 103-107.

Ahmad, S., Zahid, S. B., Salahuddin, A., Khan, A., Khan, M. H., & Ali, H. M. (2020). Trends in antibiotic susceptibility of enteric fever isolates among children attending a tertiary care hospital of Peshawar, KP. Journal of Rehman Medical Institute, 6(3), 20-23.

Amber, W., Fatima, I., Qurat-ul-ain Khalid, H. H., Khan, I. M., & Zulfqar, R. (2021). Antibiotic Resistance Pattern of Salmonella Species in Children in a Tertiary Care Hospital. Journal of Rawalpindi Medical College, 25(3).

Anjum, M., Soomro, S., Kulsoom, S., Bibil, S., Asim, S., & Riaz, M. (2021). Clinical Spectrum, Laboratory Profile and Antibiotic Susceptibility Pattern of Children with Enteric Fever at a Tertiary Care Hospital of Karachi. Journal of Islamic International Medical College (JIIMC), 16(1), 4-9.

Browne, A. J., Kashef Hamadani, B. H., Kumaran, E. A., Rao, P., Longbottom, J., Harriss, E., . . . Baker, S. (2020). Drug-resistant enteric fever worldwide, 1990 to 2018: a systematic review and meta-analysis. BMC Medicine, 18, 1-22.

Butt, M. H., Saleem, A., Javed, S. O., Ullah, I., Rehman, M. U., Islam, N., . . . Misbah, S. (2022). Rising XDR-typhoid fever cases in Pakistan: are we heading back to the pre-antibiotic era? Frontiers in public health, 9, 794868.

Chaudhry, A. R. (2022). Clinical Spectrum, Bacterological Profile and Antibiogram of Culture Proven Enteric Fever in a Private Sector Hospital in Lahore. Paper presented at the Medicinsk Forum.

Hameed, S., Izhar, M., Basheer, A., Lal, C., Rishi, S., & Basit, A. (2019). An Update on Isolation of Extensively Drug Resistant (XDR) Salmonella enterica from Blood Cultures in a Tertiary Care Centre. Proceedings SZPGMI Vol, 33(4), 20-24.

Hussain, A., Satti, L., Hanif, F., Zehra, N. M., Nadeem, S., Bangash, T. M., & Peter, A. (2019). Typhoidal Salmonella strains in Pakistan: an impending threat of extensively drug-resistant Salmonella Typhi. European Journal of Clinical Microbiology & Infectious Diseases, 38, 2145-2149.

Iqbal, J., Dehraj, I. F., Carey, M. E., Dyson, Z. A., Garrett, D., Seidman, J. C., . . . Qamar, F. N. (2020). A race against time: reduced azithromycin susceptibility in Salmonella enterica serovar Typhi in Pakistan. mSphere, 5(4), 10.1128/msphere. 00215-00220.

Khan, F. Z., Baig, S., Zameer, S., & Sharafat, S. (2018). Emerging Trends of Antibiotic Resistance pattern of Salmonella Typhi. International Journal of Pathology, 52-57.

Khan, M., Tu-Zahra, F., Gul, A., Saleem, M., Riaz, M., & Gul, W. (2022). Extensively Drug-Resistant Salmonella enterica serovar Typhi in Pediatric population during CoVID-19 Pandemic. International Journal of Infectious Diseases, 116, S4.

Malik, N., & Ahmed, M. (2016). In vitro effect of new antibiotics against clinical isolates of Salmonella Typhi. Journal of the College of Physicians and Surgeons--Pakistan, 26(4), 288-292.

Memon, A., Ahmed, M., & Iqbal, K. (2020). Frequency and antimicrobial resistance pattern of extensive-drug resistance Salmonella typhi isolates. Journal of Microbiology and Infectious Diseases, 10(02), 68-74.

Menz, B. D., Charani, E., Gordon, D. L., Leather, A. J., Moonesinghe, S. R., & Phillips, C. J. (2021). Surgical antibiotic prophylaxis in an era of antibiotic resistance: common resistant bacteria and wider considerations for practice. Infect Drug Resist, 5235-5252.

Nusrat, N., Islam, M. R., Paul, N., Rahman, N., Krishnapillai, A., Haq, M. A., & Haque, M. (2022). Clinical and Laboratory Features of Enteric Fever in Children and Antibiotic Sensitivity Pattern in a Tertiary Care Hospital of a Low-and Middle-Income Country. Cureus, 14(10).

Shah, S. A. A., Nadeem, M., Syed, S. A., Abidi, S. T. F., Khan, N., & Bano, N. (2020). Antimicrobial sensitivity pattern of Salmonella Typhi: emergence of resistant strains. Cureus, 12(11).

Shaikh, A. A., Shaikh, A., & Tahir, A. (2019). Antimicrobial resistance trends of typhoidal Salmonellae in southern Pakistan. Rawal Medical Journal, 44(1), 7-7.

Umair, M., & Siddiqui, S. A. (2020). Antibiotic susceptibility patterns of Salmonella typhi and Salmonella paratyphi in a tertiary care hospital in Islamabad. Cureus, 12(9).

Yasin, N., Rahman, H., Sarwar, Y., Qasim, M., Nisa, I., Ikram, A., . . . Khan, N. (2022). Salmonella Typhi from Northwest Pakistan: Molecular strain typing and drug resistance signature. Microbial Drug Resistance, 28(1), 120-126.