COMPARISON STUDY OF CYSTATIN C & CREATININE-BASED GFR FORMULAS WITH 51CR-EDTA CLEARANCE IN PATIENTS WITH CIRRHOSIS

I RASHID; MSN KHAN; A RAZA; S AHSAN; UB TARIQ

doi:10.54112/bcsrj.v2023i1.367

Authors

I RASHID Department of Internal Medicine, Ahalia Hospital, UAE
MSN KHAN Department of Medicine, Multan Medical and Dental College (MMDC) Multan, Pakistan
A RAZA Department of Gastroenterology & Medicine, Nishtar Medical University and Hospital (NMU & H) Multan, Pakistan
S AHSAN Department of Internal Medicine, Benazir Bhutto Hospital Rawalpindi/Rawalpindi Medical University, Pakistan
UB TARIQ Department of Medicine, Nawaz Sharif Medical College Gujrat, Pakistan

DOI:

https://doi.org/10.54112/bcsrj.v2023i1.367

Keywords:

Cystatin C, cirrhosis, glomerular filtration rate, creatinine

Abstract

This study aimed to compare cystatin C and Creatinine based GFR equations with 51Cr-EDTA clearance as the gold standard in cirrhotic patients. A prospective study was conducted in the Hepatology & Medicine Departments of Tertiary Care Hospitals. A total of 140 patients were included in the study. 66 cirrhotic patients correlated with cystatin C with creatinine and 74 patients correlating 51Cr-EDTA glomerular filtration rate to adjustments of diet in renal disease and Larsson and Hoek formulas for Cystatin C were selected for the study. Bland-Altman plots and concordance correlation coefficients were used to evaluate agreements. The correlation between cystatin C and bilirubin was poor, and the correlation between bilirubin and creatinine was strong. The medium values of creatinine and cystatin C were greater in a group with a GFR of more than 70 ml (27 patients), and their difference was significant (p <0.0001). The new GFR obtained by the creatinine formula was more accurate than GFR obtained by the cystatin C formula. With a 50% change in GFR, the creatinine formula provided a 90% GFR estimate. CysC formulas are not better for estimating glomerular filtration rate than creatinine formulas.

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