Frequency of Microalbuminuria In Hypertensive Patients With Acute Ischemic Stroke

Abstract

Microalbuminuria is an established marker of endothelial dysfunction and is associated with increased cardiovascular and cerebrovascular risk. In hypertensive patients presenting with acute ischemic stroke, the presence of microalbuminuria may indicate heightened vascular injury and poorer prognosis. Early identification may assist in risk stratification and secondary prevention. Objective: To determine the frequency of microalbuminuria in hypertensive patients presenting with acute ischemic stroke at Saidu Group of Teaching Hospital, Swat. Methods: This study was conducted on 150 hypertensive patients aged 18-65 years with acute ischemic stroke at the Department of General Medicine, Saidu Group of Teaching Hospital, Swat, from 26 September 2024 to 26 March 2025. Patients with hemorrhagic stroke, end-stage renal disease, and pregnancy were excluded. Hypertension was defined as systolic blood pressure ≥ 130 mmHg and diastolic blood pressure ≥ 80 mmHg. Microalbuminuria was assessed using spot urine albumin-creatinine ratio, with values between 30 and 300 mg/g considered positive. Data were analysed using SPSS 23. Results: The mean age of 150 patients was 51.37±12.06 years. Gender-wise, 81 patients (54.0%) were male. Microalbuminuria was diagnosed in 62 (41.3%) patients. Significant association of microalbuminuria was observed with prolonged duration of stroke, diabetes, and hypertension. Conclusion: The frequency of microalbuminuria in hypertensive patients with acute ischemic stroke in this study was 41.3%, and it was significantly associated with diabetes mellitus, smoking, and delayed presentation. Routine screening for microalbuminuria may help in early risk stratification and guide secondary prevention strategies in this high-risk population.