ROLE OF SMALL VESSEL THROMBO-EMBOLECTOMY IN LOWER LIMB SALVAGE AND ITS CLINICO PATHOLOGICAL SPECTRUM IN ACUTE LIMB ISCHEMIA

Authors

  • M NASIR Doctors Hospital and Medical Centre Lahore, Pakistan
  • I SADIQ Doctors Hospital and Medical Centre Lahore, Pakistan
  • A MUSHTAQ Doctors Hospital and Medical Centre Lahore, Pakistan

DOI:

https://doi.org/10.54112/bcsrj.v2024i1.1187

Keywords:

Acute limb ischemia, Embolectomy, Surgery , Thrombus

Abstract

Acute limb ischemia (ALI) is a vascular emergency where prompt intervention is crucial to salvage the limb. The standard treatment window is within 6 hours; beyond this period, the limb is presumed to suffer irreversible ischemic damage. However, surgical interventions like retrograde thrombo-embolectomy offer hope for limb salvage even in delayed presentations. This study investigates the efficacy of retrograde thrombo-embolectomy in small distal vessel occlusions due to thrombus or embolus in patients presenting after the 12-hour mark. Objective: To report the patients who presented to us beyond the 6-hours mark, beyond which the limb is presumed to have developed irreversible ischemic changes. The efficacy of retrograde thrombo-embolectomy in distal small vessel occlusion secondary to thrombus or embolus in delayed presentation of ALI was also evaluated. Methods: Thirty-five cases presented with acute limb ischemia for more than 12 hours. All Rutherford Grade IIa, IIb were included in the study. A prospective cross-sectional study was conducted and intra-operative findings, outcomes, post-operative complications were noted. All selected patients were operated by open surgery approach consisting of CFA thrombectomy and retrograde PTA/ATA Thrombo-embolectomy at ankle depending on thrombus site. Results: The study demonstrated a 97.1% success rate in limb salvage and functionality over 6 months follow-up. One patient had a major complication of re-thrombosis for which a repeat procedure was done. Four patients developed minor complications such as wound infection, ray amputation, needing wound debridement. Conclusion: Surgical intervention is possible for acute ischemic limb with delayed presentation (>12 hour). An open surgical approach is a safe and reliable option in such patients. However, further research is needed with a wider study population to actually see benefits of surgical intervention in delayed ALI presentation.

Downloads

Download data is not yet available.

References

Natarajan B, Patel P, Mukherjee A. Acute Lower Limb Ischemia—Etiology, Pathology, and Management. International Journal of Angiology. 2020;29(03):168-74.

Juneja A, Garuthara M, Talathi S, Rao A, Landis G, Etkin Y. Predictors of poor outcomes after lower extremity revascularization for acute limb ischemia. Vascular. 2024;32(3):632-9.

Fluck F, Augustin AM, Bley T, Kickuth R, editors. Current treatment options in acute limb ischemia. RöFo-Fortschritte auf dem Gebiet der Röntgenstrahlen und der bildgebenden Verfahren; 2020: © Georg Thieme Verlag KG.

Veenstra EB, Van der Laan MJ, Zeebregts CJ, De Heide E-J, Kater M, Bokkers RP. A systematic review and meta-analysis of endovascular and surgical revascularization techniques in acute limb ischemia. Journal of Vascular Surgery. 2020;71(2):654-68. e3.

Higashitani M, Anzai H, Mizuno A, Utsunomiya M, Umemoto T, Yamanaka T, et al. One-year limb outcome and mortality in patients undergoing revascularization therapy for acute limb ischemia: Short-term results of the Edo registry. Cardiovascular intervention and therapeutics. 2021;36:226-36.

Perry M, Callas PW, Alef MJ, Bertges DJ. Outcomes of peripheral vascular interventions via retrograde pedal access for chronic limb-threatening ischemia in a multicenter registry. Journal of Endovascular Therapy. 2020;27(2):205-10.

Ghoneim BM, Elhindawy KMA, Fouad FS, Ellil MHA, Shaker AA. Role of Retrograde Tibiopedal Access in Limb Salvage in Patients with Critical Lower Limb Ischemia. International Journal of Angiology. 2024.

Siddique A, Imtiaz N, Pervaiz K, Ali K, Ahmad R, Haider F-e. Outcome of embolectomy in patients presenting late with acute limb ischemia. Journal of Ayub Medical College Abbottabad. 2020;32(2):263-5.

Ghweeba MM, Ghweeba MM, Abd Elhafez AEA. Trans-Tibial Retrograde Approach for Below Knee Angioplasty in Chronic Critical Limb Ischemia. Medicine Updates. 2023;14(14):63-80.

Isaza-Meza M, Corso-Ramírez JM, Flórez-Amaya P, Cabrales-Arévalo JR, Barrera-Carvajal JG. Endovascular retrograde tibial access for limb salvage in Chronic Limb-Threatening Ischemia: A Case Report. 2023.

Cho S, Lee SH, Joh JH. Complete revascularization of acute limb ischemia with distal pedal access. Vascular and Endovascular Surgery. 2020;54(1):69-74.

Korosoglou G, Schmidt A, Stavroulakis K, Pollert D, Giusca S, Lichtenberg M, et al. Retrograde access for the recanalization of lower-limb occlusive lesions: a German experience report in 1,516 consecutive patients. Cardiovascular Interventions. 2022;15(3):348-51.

Jethwa B, Sharma R, Tanner J, Rahimi OB. Collateral circulation of the femoral and genicular systems in human lower limbs is highly uncommon. Journal of Anatomy. 2020;237(4):791-7.

Zhang K, Chen X, Li H, Feng G, Nie Y, Wei Y, et al. A nitric oxide-releasing hydrogel for enhancing the therapeutic effects of mesenchymal stem cell therapy for hindlimb ischemia. Acta biomaterialia. 2020;113:289-304.

Downloads

Published

2024-10-31

How to Cite

NASIR, M., SADIQ, I., & MUSHTAQ, A. (2024). ROLE OF SMALL VESSEL THROMBO-EMBOLECTOMY IN LOWER LIMB SALVAGE AND ITS CLINICO PATHOLOGICAL SPECTRUM IN ACUTE LIMB ISCHEMIA. Biological and Clinical Sciences Research Journal, 2024(1), 1187. https://doi.org/10.54112/bcsrj.v2024i1.1187