ASSOCIATION BETWEEN HYPOMAGNESEMIA AND SERUM LACTATE LEVELS IN PATIENTS WITH SEPSIS

A TARIQ; MQ ABBAS; SM ABBAS; H AMJAD; MH ZIA; M USMAN

doi:10.54112/bcsrj.v2024i1.1161

Authors

A TARIQ Ghurki Trust Teaching Hospital Lahore, Pakistan
MQ ABBAS Department of Anesthesia Sindh Institute of Urology and Transplantation Karachi, Pakistan
SM ABBAS Department of Anesthesiology, SICU & Pain Management, Pakistan
H AMJAD Zia Fatima Hospital Phalia Road, Mandi Bahauddin, Pakistan
MH ZIA Ghurki Trust Teaching Hospital Lahore, Pakistan
M USMAN Ghurki Trust Teaching Hospital Lahore, Pakistan

DOI:

https://doi.org/10.54112/bcsrj.v2024i1.1161

Keywords:

Sepsis, Hypomagnesemia, Serum Lactate, Retrospective Study, ICU, Mortality, Metabolic Dysfunction

Abstract

Sepsis is a critical condition that often leads to systemic inflammation, organ dysfunction, and high mortality rates. It is well known that metabolic abnormalities play a significant role in the pathophysiology of sepsis. Objective: This study aims to investigate the association between hypomagnesemia and serum lactate levels in patients with sepsis, hypothesizing that low magnesium levels may be linked to increased lactate production and worse clinical outcomes. Methods: A retrospective observational study was conducted at Ghurki Trust Teaching Hospital Lahore from January 2024 to June 2024. Data were collected from 255 adult patients diagnosed with sepsis. Patients were divided into two groups based on their serum magnesium levels: those with normal magnesium levels (≥1.7 mg/dL) and those with hypomagnesemia (<1.7 mg/dL). Serum lactate levels were measured within the first 24 hours of ICU admission. Results: Out of the 255 patients, 108 (42.4%) were found to have hypomagnesemia. Patients with hypomagnesemia had significantly higher serum lactate levels compared to those with normal magnesium levels, with mean lactate levels of 4.1 ± 1.2 mmol/L in the hypomagnesemia group versus 2.7 ± 0.9 mmol/L in the normal magnesium group (p < 0.001). Conclusions: This study shows a significant association between hypomagnesemia and elevated serum lactate levels in patients with sepsis.

Downloads

Download data is not yet available.

References

Tonai K, Katayama S, Koyama K, Imahase H, Nunomiya S. Association between hypomagnesemia and serum lactate levels in patients with sepsis: a retrospective observational study. Journal of Anesthesia, Analgesia and Critical Care. 2024;4(1):23.

Tonai K, Katayama S, Koyama K, Sata N, Tomioka Y, Imahase H, et al. Association between hypomagnesemia and coagulopathy in sepsis: a retrospective observational study. BMC anesthesiology. 2022;22(1):359.

Li L, Li L, Zhao Q, Liu X, Liu Y, Guo K, et al. High serum magnesium level is associated with increased mortality in patients with sepsis: an international, multicenter retrospective study. MedComm. 2024;5(10):e713.

Noormandi A, Khalili H, Mohammadi M, Abdollahi A. Effect of magnesium supplementation on lactate clearance in critically ill patients with severe sepsis: a randomized clinical trial. European journal of clinical pharmacology. 2020;76:175-84.

Gu W-J, Duan X-J, Liu X-Z, Cen Y, Tao L-Y, Lyu J, et al. Association of magnesium sulfate use with mortality in critically ill patients with sepsis: a retrospective propensity score-matched cohort study. British Journal of Anaesthesia. 2023;131(5):861-70.

Wang H, Huang J, Jin X, Chen C, Zhang A, Wu Y, et al. Hypermagnesaemia, but not hypomagnesaemia, is a predictor of inpatient mortality in critically ill children with sepsis. Disease markers. 2022;2022(1):3893653.

Hidayat AAA. The Increasing Obedience and Changes in Blood Pressure Through Family Empowerment Model in Elderly People with Hypertension. Indian Journal of Public Health Research & Development. 2020;11(3).

Xia X, Guo H, Sun H. Association between serum magnesium trajectory and in-hospital mortality in hospitalized patients with sepsis: an analysis of the MIMIC-? database. Magnesium Research. 2023;36(3).

Li L, Zhou S, Huang Q, Hu H, Wu J, Chen Z, et al. Active Supplementation With Magnesium Sulfate May Be Associated With Worse Prognosis in Sepsis: A Retrospective Analysis of The MIMIC-IV Database. 2021.

Sarmin M, Begum M, Islam F, Afroze F, Shahrin L, Sharifuzzaman, et al. Factors associated with severe sepsis in diarrheal adults and their outcome at an urban hospital, Bangladesh: A retrospective analysis. Plos one. 2021;16(9):e0257596.

Díez JJ, Iglesias P, García A, Martín-Casasempere I, Bernabéu-Andréu FA. Serum calcium, magnesium, and phosphorus levels in patients with COVID-19: Relationships with poor outcome and mortality. Hormone and Metabolic Research. 2023;55(01):31-9.

Santos MO, Gonçalves LC, Silva PA, Moreira AL, Ito CR, Peixoto FA, et al. Multisystem inflammatory syndrome (MIS-C): a systematic review and meta-analysis of clinical characteristics, treatment, and outcomes. Jornal de pediatria. 2022;98(4):338-49.

Saglietti F, Girombelli A, Marelli S, Vetrone F, Balzanelli MG, Tabaee Damavandi P. Role of magnesium in the intensive care unit and immunomodulation: a literature review. Vaccines. 2023;11(6):1122.

Catalano A, Bellone F, Chilà D, Loddo S, Morabito N, Basile G, et al. Rates of hypomagnesemia and hypermagnesemia in medical settings. Magnesium Research. 2021;34(1).

Zhu L, Bao X, Bi J, Lin Y, Shan C, Fan X, et al. Serum magnesium in patients with severe acute respiratory syndrome coronavirus 2 from Wuhan, China. Magnesium research. 2021;34(3).

Mwachaka PM. Evaluation of Serum Electrolyte Abnormalities in Patients With Severe Head Injury at The kenyatta National Hospital in Kenya. 2020.

Liu Y, Zheng Y, Ding S. The correlation between serum calcium levels and prognosis in patients with severe acute osteomyelitis. Frontiers in Immunology. 2024;15:1378730.

Stevens JS, Moses AA, Nickolas TL, Husain SA, Mohan S. Increased mortality associated with hypermagnesemia in severe COVID-19 illness. Kidney360. 2021;2(7):1087-94.

Gunay S, Caliskan S, Sigirli D. Relationship of magnesemia with myocardial damage and mortality in patients with COVID-19. Magnesium research. 2021;34(3).