CARDIAC CT DIAGNOSTIC UTILITY IN THE ASSESSMENT OF BICUSPID AORTIC STENOSIS: A COMPARATIVE STUDY WITH ECHOCARDIOGRAPHY AND OPERATIONAL RESULTS

Authors

  • F Kalsoom Department of Radiology Chaudhary Pervez Ellahi Institute of Cardiology (CPEIC) Multan, Pakistan
  • K MUSHTAQ Department of Radiology Chaudhary Pervez Ellahi Institute of Cardiology (CPEIC) Multan, Pakistan
  • U ZAFAR Department of Radiology Chaudhary Pervez Ellahi Institute of Cardiology (CPEIC) Multan, Pakistan
  • S TARIQ Department of Radiology Chaudhary Pervez Ellahi Institute of Cardiology (CPEIC) Multan, Pakistan

DOI:

https://doi.org/10.54112/bcsrj.v2022i1.785

Keywords:

Aortic Valve, Bicuspid Valve, Cardiac CT, Echocardiography

Abstract

The bicuspid aortic valve is the most prevalent congenital cardiac abnormality, often leading to symptoms in middle-aged individuals. It is a significant determinant of aortic valve dysfunction in the young population. This study aimed to assess the diagnostic utility of cardiac CT in evaluating individuals with bicuspid aortic valve disease. Thirty consecutive individuals with aortic stenosis who underwent surgical valve repair from January 2021 to July 2022 at Chaudhary Pervez Ellahi Institute of Cardiology Multan, Pakistan, were included in the study. ECG-gated CT and echocardiography were performed utilising a 64-MDCT scanner. Imaging findings regarding the number of aortic valve leaflets (bicuspid or tricuspid) were compared with intraoperative observations. Statistical analysis was conducted using one-way univariate analysis of variance. The aortic valve area (AVA) was assessed using CT and echocardiography, and the results were statistically analysed using a paired Student's t-test.: Eleven 30 patients had bicuspid aortic valves, while nineteen had tricuspid aortic valves. Echocardiography failed to determine the type of aortic valve in five patients due to severe calcification. The sensitivity, specificity, positive predictive value, and negative predictive value for detecting a bicuspid aortic valve were 75.5%, 60.3%, 67.6%, and 93.5%, respectively, for echocardiography, and 93.7%, 100%, 100%, and 96.7%, respectively, for CT. CT findings were not significantly different from perioperative observations (p = 0.87), while echocardiographic results were (p < 0.05). CT and echocardiography yielded AVA measurements of 0.931 ± 0.42 cm2 and 0.649 ± 0.241 cm2, respectively, with a significant difference (p < 0.05). ECG-gated cardiac CT provides a reliable morphologic diagnosis of bicuspid aortic stenosis, especially in individuals with significant valve calcification.

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References

Sillesen A-S, Vøgg O, Pihl C, Raja AA, Sundberg K, Vedel C, et al. Prevalence of bicuspid aortic valve and associated aortopathy in newborns in Copenhagen, Denmark. Jama. 2021;325(6):561-7.

Yang L-T, Tribouilloy C, Masri A, Bax JJ, Delgado V, Girdauskas E, et al. Clinical presentation and outcomes of adults with bicuspid aortic valves: 2020 update. Progress in Cardiovascular Diseases. 2020;63(4):434-41.

Niaz T, Fernandes SM, Sanders SP, Michelena H, Hagler DJ. Clinical history and management of bicuspid aortic valve in children and adolescents. Progress in Cardiovascular Diseases. 2020;63(4):425-33.

Sun BJ, Song J-K. Bicuspid aortic valve: evolving knowledge and new questions. Heart. 2023;109(1):10-7.

Dutta P, James JF, Kazik H, Lincoln J. Genetic and developmental contributors to aortic stenosis. Circulation research. 2021;128(9):1330-43.

Yang L-T, Ye Z, Wajih Ullah M, Maleszewski JJ, Scott CG, Padang R, et al. Bicuspid aortic valve: long-term morbidity and mortality. European heart journal. 2023;44(43):4549-62.

Yoshioka Y, Yajima S, Sakaniwa R, Tadokoro N, Kainuma S, Kawamoto N, et al. Does the residual aorta dilate after replacement of the bicuspid aortic valve and ascending aorta? Journal of Thoracic Disease. 2023;15(3):994.

Shin HJ, Kim WK, Kim DK, Kim HJ, Kim JB. Prognosis of Unrepaired Ascending Aorta after the Surgical Replacement of Bicuspid Aortic Valves. Journal of Chest Surgery. 2023;56(4):255.

Tanaka R, Yoshioka K, Niinuma H, Ohsawa S, Okabayashi H, Ehara S. Diagnostic value of cardiac CT in the evaluation of bicuspid aortic stenosis: comparison with echocardiography and operative findings. American Journal of Roentgenology. 2010;195(4):895-9.

Pandian NG, Kim JK, Arias-Godinez JA, Marx GR, Michelena HI, Mohan JC, et al. Recommendations for the use of echocardiography in the evaluation of rheumatic heart disease: a report from the American Society of Echocardiography. Journal of the American Society of Echocardiography. 2023;36(1):3-28.

Canciello G, Pate S, Sannino A, Borrelli F, Todde G, Grayburn P, et al. Pitfalls and Tips in the Assessment of Aortic Stenosis by Transthoracic Echocardiography. Diagnostics. 2023;13(14):2414.

Efrimescu CI, Moorthy A, Griffin M. Rescue transesophageal echocardiography: a narrative review of current knowledge and practice. Journal of Cardiothoracic and Vascular Anesthesia. 2023;37(4):584-600.

Thaden JJ, Malouf JF, Rehfeldt KH, Ashikhmina E, Bagameri G, Enriquez-Sarano M, et al. Adult intraoperative echocardiography: A comprehensive review of current practice. Journal of the American Society of Echocardiography. 2020;33(6):735-55. e11.

Kauhanen P. Dilatation of the ascending aorta: imaging, prevalence and associated factors: Itä-Suomen yliopisto; 2020.

Rodríguez-Palomares JF, Dux-Santoy L, Guala A, Galian-Gay L, Evangelista A. Mechanisms of aortic dilation in patients with bicuspid aortic valve: JACC state-of-the-art review. Journal of the American College of Cardiology. 2023;82(5):448-64.

Abdel Samea ME, Zytoon AA, Abo Mostafa AMAE, Hassanein SA-H. Global left ventricular function assessment by ECG-gated multi-detector CT (MDCT): revised role in relation to 2D transthoracic echocardiography. Egyptian Journal of Radiology and Nuclear Medicine. 2020;51:1-9.

Coffey S, Roberts-Thomson R, Brown A, Carapetis J, Chen M, Enriquez-Sarano M, et al. Global epidemiology of valvular heart disease. Nature Reviews Cardiology. 2021;18(12):853-64.

Zubair MM, de Beaufort HW, Belvroy VM, Schwein A, Irshad A, Mohamed A, et al. Impact of cardiac cycle on thoracic aortic geometry—morphometric analysis of ECG gated computed tomography. Annals of Vascular Surgery. 2020;65:174-82.

Doris MK, Jenkins W, Robson P, Pawade T, Andrews JP, Bing R, et al. Computed tomography aortic valve calcium scoring for the assessment of aortic stenosis progression. Heart. 2020;106(24):1906-13.

Mittal TK, Reichmuth L, Bhattacharyya S, Jain M, Baltabaeva A, Haley SR, et al. Inconsistency in aortic stenosis severity between CT and echocardiography: prevalence and insights into mechanistic differences using computational fluid dynamics. Open heart. 2019;6(2):e001044.

Nabeshima Y, Nagata Y, Negishi K, Seo Y, Ishizu T, Sato K, et al. Direct comparison of severity grading assessed by two-dimensional, three-dimensional, and Doppler echocardiography for predicting prognosis in asymptomatic aortic stenosis. Journal of the American Society of Echocardiography. 2018;31(10):1080-90. e3.

Sacchi S, Dhutia NM, Shun-Shin MJ, Zolgharni M, Sutaria N, Francis DP, et al. Doppler assessment of aortic stenosis: a 25-operator study demonstrating why reading the peak velocity is superior to velocity time integral. European Heart Journal-Cardiovascular Imaging. 2018;19(12):1380-9.

Kim J, Kim SM, Ahn J, Kim J, Choe YH. Diagnostic performance of cardiac CT and transthoracic echocardiography for detection of surgically confirmed bicuspid aortic valve: effect of calcium extent and valve subtypes. Journal of the Korean Society of Radiology. 2023;84(6):1324.

Everett RJ, Newby DE, Jabbour A, Fayad ZA, Dweck MR. The role of imaging in aortic valve disease. Current cardiovascular imaging reports. 2016;9:1-14.

Doris MK. Advanced Imaging to Detect Disease Burden, Activity and Progression in Coronary Artery Disease and Aortic Valve Disease.

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Published

2022-11-29

How to Cite

Kalsoom, F., MUSHTAQ , K., ZAFAR , U., & TARIQ , S. (2022). CARDIAC CT DIAGNOSTIC UTILITY IN THE ASSESSMENT OF BICUSPID AORTIC STENOSIS: A COMPARATIVE STUDY WITH ECHOCARDIOGRAPHY AND OPERATIONAL RESULTS. Biological and Clinical Sciences Research Journal, 2022(1). https://doi.org/10.54112/bcsrj.v2022i1.785

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Original Research Articles

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