THE POTENTIAL CORRELATION BETWEEN HYPERURICEMIA AND HYPERTHYROIDISM IS BEING EXAMINED

AM KHAN; Z KHAN; A BASIT; MA KHAN; A ALI

doi:10.54112/bcsrj.v2023i1.619

Authors

AM KHAN Department of Medicine, MTI, LRH, Peshawar, Pakistan
Z KHAN Department of Medicine, MTI, LRH, Peshawar, Pakistan
A BASIT Department of Pulmonology, MTI, LRH, Peshawar, Pakistan
MA KHAN Treatment Coordinator HDL Programmatic Management of Drug Resistant TB Unit, LRH Peshawar, Pakistan
A ALI Department of Medicine (Professor), MTI, MMC Mardan, Pakistan

DOI:

https://doi.org/10.54112/bcsrj.v2023i1.619

Keywords:

Hyperuricemia, Hyperthyroidism, Thyroid function, Uric acid metabolism, Metabolic disorders

Abstract

Hyperuricemia is characterized by high levels of uric acid in the bloodstream, while hyperthyroidism refers to excessive thyroid gland activity. Both conditions can significantly affect a patient's quality of life. This study aimed to comprehensively analyze a sample size of 100 patients at MTI LRH, Peshawar, to address the research gap in this area. The study employed a prospective design, which involved collecting patient data over time. The study was conducted at the Department of Medicine, Medical Teaching Institution Lady Reading Hospital (MTI LRH), Peshawar, from January to July 2021. One hundred patients were chosen randomly from those who presented at MTI LRH during the study period. The inclusion criteria were individuals 18 or older who had documented thyroid function test results and had blood uric acid levels on record. The study participants included 50 males and 50 females, with a median age of 41. Most participants (55%) were between the ages of 31 and 50, with 25% in the 31-40 age group and 30% in the 41-50 age group. The remaining 45% were younger than 30 or older than 50. The data showed a slight negative correlation (r = -0.15) between TSH and uric acid levels, indicating that as TSH levels decreased, uric acid levels increased. However, this correlation was not statistically significant (p=0.20). The study found no significant correlation between thyroid function and uric acid levels in the sample population. Although there have been inconsistencies in previous literature on this topic, our results were consistent with past investigations.

Downloads

Download data is not yet available.

References

Alqahtani, S. A. M. (2021). Prevalence and characteristics of thyroid abnormalities and its association with anemia in ASIR region of Saudi Arabia: a cross-sectional study. Clinics and practice 11, 494-504.

Bashboosh, N. N., Mohammed, M. H., Najm, R. A., and Kadhim, N. J. (2018). Study the effects of some hormonal and physiological parameters in patients with thyroid disease. Journal of Pharmaceutical Sciences and Research 10, 1541-1544.

Borghi, C., Agabiti-Rosei, E., Johnson, R. J., Kielstein, J. T., Lurbe, E., Mancia, G., Redon, J., Stack, A. G., and Tsioufis, K. P. (2020). Hyperuricemia and gout in cardiovascular, metabolic, and kidney disease. European journal of internal medicine 80, 1-11.

Chao, G., Zhu, Y., and Fang, L. (2019). Retrospective analysis of the correlation between uric acid and thyroid hormone in people with normal thyroid function. Journal of Diabetes Research 2019.

Chen, C., Xia, F., Chen, Y., Zhang, K., Cheng, J., Li, Q., Han, B., Zhao, L., Zhu, C., and Wang, N. (2018). Association between thyroid-stimulating hormone and renal function: a Mendelian randomization study. Kidney and Blood Pressure Research 43, 1121-1130.

Chen, X., Wang, J.-j., Yu, L., Wang, H.-y., and Sun, H. (2021). The association between BMI, smoking, drinking and thyroid disease: a cross-sectional study in Wuhan, China. BMC endocrine disorders 21, 1-10.

Fathallah-Shaykh, S. A., and Cramer, M. T. (2014). Uric acid and the kidney. Pediatric nephrology 29, 999-1008.

Iwen, K. A., Schröder, E., and Brabant, G. (2013). Thyroid hormones and the metabolic syndrome. European thyroid journal 2, 83-92.

Kwon, C. H., Lee, S. H., Lee, J.-Y., Ryu, S., and Sung, K.-C. (2018). Uric acid and risk of atrial fibrillation in the Korean general population. Circulation Journal 82, 2728-2735.

Maiuolo, J., Oppedisano, F., Gratteri, S., Muscoli, C., and Mollace, V. (2016). Regulation of uric acid metabolism and excretion. International journal of cardiology 213, 8-14.

Patel, H., and Shah, D. (2020). Hyperuricemia prevalence in Indian subjects with underlying comorbidities of hypertension and/or type 2 diabetes: a retrospective study from subjects attending hyperuricemia screening camps.

San Koo, B., Jeong, H.-J., Son, C.-N., Kim, S.-H., Kim, H. J., Kim, G.-H., and Jun, J.-B. (2021). Distribution of serum uric acid levels and prevalence of hyper-and hypouricemia in a Korean general population of 172,970. The Korean Journal of Internal Medicine 36, S264.

Xu, J., Wang, B., Li, Q., Yao, Q., Jia, X., Song, R., and Zhang, J.-a. (2019). Risk of thyroid disorders in patients with gout and hyperuricemia. Hormone and Metabolic Research 51, 522-530.

Yanai, H., Adachi, H., Hakoshima, M., and Katsuyama, H. (2021). Molecular biological and clinical understanding of the pathophysiology and treatments of hyperuricemia and its association with metabolic syndrome, cardiovascular diseases and chronic kidney disease. International journal of molecular sciences 22, 9221.

Yuan, H., Zhao, J., Xie, E., Yi, L., Zheng, Z., Geng, J., Yuan, H., Zhao, J., Xie, E., and Yi, L. (2021). Endocrine and Metabolic Diseases. In "Clinical Molecular Diagnostics", pp. 665-716. Springer.

Zeng, X.-W., Lodge, C. J., Dharmage, S. C., Bloom, M. S., Yu, Y., Yang, M., Chu, C., Li, Q.-Q., Hu, L.-W., and Liu, K.-K. (2019). Isomers of per-and polyfluoroalkyl substances and uric acid in adults: Isomers of C8 Health Project in China. Environment international 133, 105160.