PERIODONTITIS AND CARDIOVASCULAR DISEASE AS A SHARED CLINICAL CHALLENGE IN PATIENT CARE
DOI:
https://doi.org/10.54112/bcsrj.v2023i1.458Keywords:
Cardiovascular disease, periodontitis, radiographic, oral, hypertensionAbstract
Cardiovascular disease (CVD) remains the leading cause of death, accounting for approximately one-third of all deaths worldwide. The primary aim of the study is to find the link between periodontitis and cardiovascular disease as a shared clinical challenge in patient care. This retrospective observational cohort study was conducted in Jinnah Medical and Dental College Karachi from May 2023 to August 2023. The study included a total of 230 patients from a diverse patient population. Patient data were collected meticulously through a comprehensive dental and medical records review. A total of 230 patients were included in this retrospective observational cohort study. Patient demographics, including age and gender, were documented to provide an overview of the study population. The study included 230 patients with a mean age of 45. 55% of the participants were male, and 45% were female. Based on clinical measurements, 35% of patients showed mild periodontitis, 45% moderate periodontitis, and 20% severe periodontitis. Radiographic evidence of bone loss was observed in 60% of the patients. 40% of the patients had a documented history of cardiovascular diseases, including coronary artery disease, myocardial infarction, stroke, or hypertension.It is concluded that a significant association between periodontitis and cardiovascular diseases has been found. While the precise mechanisms remain fully understood, these findings underscore the importance of comprehensive healthcare that considers both oral and cardiovascular health.
Downloads
References
Batty, G. D., Jung, K. J., Mok, Y., Lee, S. J., Back, J. H., Lee, S., & Jee, S. H. (2018). Oral health and later coronary heart disease: cohort study of one million people. European journal of preventive cardiology, 25(6), 598-605. doi: 10.1177/2047487318759112
Beck, J. D., Eke, P., Lin, D., Madianos, P., Couper, D., Moss, K., ... & Offenbacher, S. (2005). Associations between IgG antibody to oral organisms and carotid intima–medial thickness in community-dwelling adults. Atherosclerosis, 183(2), 342-348. doi: 10.1016/j.atherosclerosis.2005.03.017
Chen, D. Y., Lin, C. H., Chen, Y. M., & Chen, H. H. (2016). Risk of atrial fibrillation or flutter associated with periodontitis: a nationwide, population-based, cohort study. PLoS One, 11(10), e0165601. doi: 10.1371/journal.pone.0165601
Chun, Y. H. P., Chun, K. R. J., Olguin, D. A., & Wang, H. L. (2005). Biological foundation for periodontitis as a potential risk factor for atherosclerosis. Journal of periodontal research, 40(1), 87-95. doi: 10.1111/j.1600-0765.2004.00771.x
Dietrich, T., Jimenez, M., Krall Kaye, E. A., Vokonas, P. S., & Garcia, R. I. (2008). Age-dependent associations between chronic periodontitis/edentulism and risk of coronary heart disease. Circulation, 117(13), 1668-1674.
Hansen, G. M., Egeberg, A., Holmstrup, P., & Hansen, P. R. (2016). Relation of periodontitis to risk of cardiovascular and all-cause mortality (from a Danish nationwide cohort study). The American journal of cardiology, 118(4), 489-493. doi: 10.1016/j.amjcard.2016.05.036
Hung, H. C., Joshipura, K. J., Colditz, G., Manson, J. E., Rimm, E. B., Speizer, F. E., & Willett, W. C. (2004). The association between tooth loss and coronary heart disease in men and women. Journal of public health dentistry, 64(4), 209-215.doi: 10.1111/j.1752-7325.2004.tb02755.x
Joshipura, K. J., Hung, H. C., Rimm, E. B., Willett, W. C., & Ascherio, A. (2003). Periodontal disease, tooth loss, and incidence of ischemic stroke. Stroke, 34(1), 47-52. doi: 10.1161/01.STR.0000052974.79428.0C
Joshy, G., Arora, M., Korda, R. J., Chalmers, J., & Banks, E. (2016). Is poor oral health a risk marker for incident cardiovascular disease hospitalisation and all-cause mortality? Findings from 172 630 participants from the prospective 45 and Up Study. BMJ open, 6(8), e012386. doi: 10.1136/bmjopen-2016-012386
Larvin, H., Kang, J., Aggarwal, V. R., Pavitt, S., & Wu, J. (2021). Risk of incident cardiovascular disease in people with periodontal disease: a systematic review and meta‐analysis. Clinical and experimental dental research, 7(1), 109-122. doi: 10.1002/cre2.336
Leng, Y., Hu, Q., Ling, Q., Yao, X., Liu, M., Chen, J., ... & Dai, Q. (2023). Periodontal disease is associated with the risk of cardiovascular disease independent of sex: A meta-analysis. Frontiers in Cardiovascular Medicine, 10, 1114927. https://doi.org/10.3389/fcvm.2023.1114927.
Saliasi, I., Llodra, J. C., Bravo, M., Tramini, P., Dussart, C., Viennot, S., & Carrouel, F. (2018). Effect of a toothpaste/mouthwash containing Carica papaya leaf extract on interdental gingival bleeding: a randomized controlled trial. International Journal of Environmental Research and Public Health, 15(12), 2660.doi: 10.3390/ijerph15122660
Sanz, M., Marco del Castillo, A., Jepsen, S., Gonzalez‐Juanatey, J. R., D’Aiuto, F., Bouchard, P., ... & Wimmer, G. (2020). Periodontitis and cardiovascular diseases: Consensus report. Journal of clinical periodontology, 47(3), 268-288. https://doi.org/10.1111/jcpe.13189.
Senba, T., Kobayashi, Y., Inoue, K., Kaneto, C., Inoue, M., Toyokawa, S., ... & Miyoshi, Y. (2008). The association between self-reported periodontitis and coronary heart disease-From my health up study. Journal of occupational health, 50(3), 283-287. doi: 10.1539/joh.L7066
Shiheido, Y., Maejima, Y., Suzuki, J. I., Aoyama, N., Kaneko, M., Watanabe, R., ... & Isobe, M. (2016). Porphyromonas gingivalis, a periodontal pathogen, enhances myocardial vulnerability, thereby promoting post-infarct cardiac rupture. Journal of molecular and cellular cardiology, 99, 123-137. doi: 10.1016/j.yjmcc.2016.03.017
Srisuwantha, R., Shiheido, Y., Aoyama, N., Sato, H., Kure, K., Laosrisin, N., ... & Suzuki, J. I. (2017). Porphyromonas gingivalis elevated high-mobility group box 1 levels after myocardial infarction in mice. International Heart Journal, 58(5), 762-768.doi: 10.1536/ihj.16-500
Steven, S., Frenis, K., Oelze, M., Kalinovic, S., Kuntic, M., Bayo Jimenez, M. T., ... & Daiber, A. (2019). Vascular inflammation and oxidative stress: major triggers for cardiovascular disease. Oxidative medicine and cellular longevity, 2019. doi: 10.1155/2019/7092151
Teles, R., & Wang, C. Y. (2011). Mechanisms involved in the association between peridontal diseases and cardiovascular disease. Oral diseases, 17(5), 450-461. doi: 10.1111/j.1601-0825.2010.01784.x
Vidal, F., Cordovil, I., Figueredo, C. M. S., & Fischer, R. G. (2013). Non‐surgical periodontal treatment reduces cardiovascular risk in refractory hypertensive patients: a pilot study. Journal of clinical periodontology, 40(7), 681-687. doi: 10.1111/jcpe.12110
Yu, Y. H., Chasman, D. I., Buring, J. E., Rose, L., & Ridker, P. M. (2015). Cardiovascular risks associated with incident and prevalent periodontal disease. Journal of clinical periodontology, 42(1), 21-28. doi: 10.1111/jcpe.12335
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2023 MI KHAN, M HAMZA, M ATHAR, AA ALI, M HASHMI, UU HAQ
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.