PREVENTIVE EFFECTS OF FIGS POWDER & GARLIC POWDER IN MALE ALBINO RATS WITH INDUCED DYSLIPIDEMIA
DOI:
https://doi.org/10.54112/bcsrj.v2023i1.372Keywords:
Lipid Profile, Dyslipidemia, Male Albino Rats, Figs (Ficus Carica), Garlic (Allium Sativum)Abstract
Dyslipidemia is one of the predisposing factors for the development of cardiovascular diseases due to the formation of atherosclerosis. Statin drugs are commonly used for the management of dyslipidemia but due to different side effects, drug resistance and affordability issues now, researchers working on the different preventive and curative effects of different natural herbs, fruits, etc. this study aimed to evaluate & compare the preventive effects of Ficus Carica & Allium Sativum on serum lipid profile levels in albino rats on induction of dyslipidemia. This experimental study was conducted at the Department of Biochemistry Liaquat University of Medical & Health Sciences (LUMHS) Jamshoro, Pakistan. Total of 24 male albino rats weighing of 170-190 grams were purchased from the Ojha campus of DUMHS Karachi Pakistan and caged at the Animal House of Agriculture University Tando Jam Pakistan. Twenty-four male albino rats were divided into four groups; each group contained 6 rats, group A as control group received a normal diet; group B rats received high fatty diet; group C rats received high fatty diet along with figs powder; group D rats received a high fatty diet with garlic powder with the calculated and proper dose for six weeks. After six weeks, orbital capillary blood samples were drawn to estimate lipid profile parameters. Lipid profile performed on Cobas chemical analyzer of Roche Hitachi at Diagnostic & Research Laboratory LUMHS. The Statistical data was analyzed by SPSS version 21 by applying ANOVA test for significance. The serum cholesterol level was highly observed in group B rats, and serum cholesterol level was significantly (P < .001) low in the group C & D rats in comparison to group B male albino rats. The serum T.G. level is highly observed in group B rats, T.G.’s level is significantly (P < .001) low in the group C & D rats compared to group B male albino rats. The serum LDL level is highly observed in group B rats, with a significant serum LDL level (P = 0.05) low in the group C & D rats compared to group B male albino rats. The serum HDL level more decline in group B rats serum HDL level was significantly (P = 0.05) high in the group C & D rats with the comparison to group B male albino rats. Figs and garlic powder had a significant role in normal levels of different lipid profile parameters. This study concluded that figs powder and garlic powder could perform a preventive role in the development of dyslipidemia.
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Abdel-Baky, E. S., and Abdel-Rahman, O. N. (2020). Cardioprotective effects of the garlic (Allium sativum) in sodium fluoride-treated rats. The Journal of Basic and Applied Zoology 81, 1-7.
Alam, U., Al-Bazz, D. Y., and Soran, H. (2021). Bempedoic acid: the new kid on the block for the treatment of Dyslipidemia and LDL cholesterol: a narrative review. Diabetes Therapy 12, 1779-1789.
Ali, A., and Sasidharan, P. (2022). Impact of Diet and Lifestyle Modification and Weight Reduction on Essential Hypertension. Clinical Case Reports and Clinical Study 6.
Ansari, M. H., and Mahapatra, D. K. (2021). A short overview on Anti-diabetic natural products: Reviewing the herbotherapeutic potentials. Natural Products Pharmacology and Phytochemicals for Health Care, 1-22.
Arafat, E. A., Youssef, E. M., and Khalaf, H. A. (2021). The possible alleviating effect of garlic supplement on the neural retina in a rat model of hypercholesterolemia: a histological and immunohistochemical study. European Journal of Histochemistry: EJH 65.
Coenen, D. M., Heinzmann, A. C., Karel, M. F., Cosemans, J. M., and Koenen, R. R. (2021). The multifaceted contribution of platelets in the emergence and aftermath of acute cardiovascular events. Atherosclerosis 319, 132-141.
El-Koofy, N. M., Fattouh, A. M., Ramadan, A., Elmonem, M. A., and Hamed, D. H. (2022). Early myocardial functional abnormalities in primary dyslipidemia: clinical and echocardiographic observations in young children from a highly consanguineous population. Clinical and Experimental Pediatrics 65, 410.
Elkordy, A. A., Haj-Ahmad, R. R., Awaad, A. S., and Zaki, R. M. (2021). An overview on natural product drug formulations from conventional medicines to nanomedicines: Past, present and future. Journal of Drug Delivery Science and Technology 63, 102459.
Ezeorba, T. P. C., Chukwudozie, K. I., Ezema, C. A., Anaduaka, E. G., Nweze, E. J., and Okeke, E. S. (2022). Potentials for health and therapeutic benefits of garlic essential oils: Recent findings and future prospects. Pharmacological Research-Modern Chinese Medicine 3, 100075.
Golder, S., Smith, K., O’Connor, K., Gross, R., Hennessy, S., and Gonzalez-Hernandez, G. (2021). A comparative view of reported adverse effects of statins in social media, regulatory data, drug information databases and systematic reviews. Drug safety 44, 167-179.
Hasheminasabgorji, E., and Jha, J. C. (2021). Dyslipidemia, diabetes and atherosclerosis: role of inflammation and ROS-redox-sensitive factors. Biomedicines 9, 1602.
Jayaraman, S., Roy, A., Vengadassalapathy, S., Sekar, R., Veeraraghavan, V. P., Rajagopal, P., Rengasamy, G., Mukherjee, R., Sekar, D., and Manjunathan, R. (2021). An Overview on the Therapeutic Function of Foods Enriched with Plant Sterols in Diabetes Management. Antioxidants 10, 1903.
Miao, Q., Wang, R., Bai, D., Xue, X., Xu, J., Sun, X., and Liu, L. (2020). Antiatherosclerosis properties of total saponins of garlic in rats. Evidence-Based Complementary and Alternative Medicine 2020.
Mir, R., Elfaki, I., Khullar, N., Waza, A. A., Jha, C., Mir, M. M., Nisa, S., Mohammad, B., Mir, T. A., and Maqbool, M. (2021). Role of selected miRNAs as diagnostic and prognostic biomarkers in cardiovascular diseases, including coronary artery disease, myocardial infarction and atherosclerosis. Journal of Cardiovascular Development and Disease 8, 22.
Nigatie, M., Melak, T., Asmelash, D., and Worede, A. (2022). Dyslipidemia and Its Associated Factors Among Helicobacter pylori-Infected Patients Attending at University of Gondar Comprehensive Specialized Hospital, Gondar, North-West Ethiopia: A Comparative Cross-Sectional Study. Journal of Multidisciplinary Healthcare, 1481-1491.
Ruiz León, A., Rodríguez Muñoz, R. d. C., Rodríguez Cadalso, A. E., Ibáñez Silva, L. P., Águila Turiño, E. R., Rodríguez Galdó, L. L., and Pomares Ortega, Ú. C. (2021). Garlic: Medicinal Plant and Natural Aromatic Condiment.
Russo, F., Caporaso, N., Paduano, A., and Sacchi, R. (2014). Phenolic compounds in fresh and dried figs from Cilento (Italy), by considering breba crop and full crop, in comparison to Turkish and Greek dried figs. Journal of food science 79, C1278-C1284.
Saad, B., Kmail, A., and Haq, S. Z. (2022). Anti-diabesity Middle Eastern medicinal plants and their action mechanisms. Evidence-Based Complementary and Alternative Medicine 2022.
Sasi, M., Kumar, S., Kumar, M., Thapa, S., Prajapati, U., Tak, Y., Changan, S., Saurabh, V., Kumari, S., and Kumar, A. (2021). Garlic (Allium sativum L.) bioactives and its role in alleviating oral pathologies. Antioxidants 10, 1847.
Shang, A., Cao, S.-Y., Xu, X.-Y., Gan, R.-Y., Tang, G.-Y., Corke, H., Mavumengwana, V., and Li, H.-B. (2019). Bioactive compounds and biological functions of garlic (Allium sativum L.). Foods 8, 246.
Siyadatpanah, A., Mirzaei, F., Hossain, R., Islam, M. T., Fatemi, M., Norouzi, R., Koohestan, M. G., Namdar, F., Almeida, R. S., and Mubarak, M. S. (2022). Anti-parasitic activity of the Olea europaea and Ficus carica on Leishmania major: new insight into the anti-leishmanial agents. Biologia 77, 1795-1803.
Stephen Irudayaraj, S., Christudas, S., Antony, S., Duraipandiyan, V., Naif Abdullah, A.-D., and Ignacimuthu, S. (2017). Protective effects of Ficus carica leaves on glucose and lipids levels, carbohydrate metabolism enzymes and β-cells in type 2 diabetic rats. Pharmaceutical biology 55, 1074-1081.
Sukowati, Y. K., Johan, A., and Murwani, R. (2019). Ethanol extracts of Ficus carica fruit and leaf normalize high serum lipid profile, TNF-α, and MDA due to high fat diet in Sprague Dawley rat. Current Research in Nutrition and Food Science Journal 7, 772-782.
Sweidan, K., Sheikha, G. A., Shattat, G., Al-qirim, T., and Bkhaitan, M. (2022). Synthesis and In Vivo Hypolipidemic Effect of Some N-(Benzoylphenyl)-Carboxamide Derivatives in Triton WR-1339-Induced Hyperlipidemic Rats. Brazilian Journal of Pharmaceutical Sciences 58.
Thongtang, N., Sukmawan, R., Llanes, E. J. B., and Lee, Z.-V. (2022). Dyslipidemia management for primary prevention of cardiovascular events: Best in-clinic practices. Preventive Medicine Reports 27, 101819.
Walia, A., Kumar, N., Singh, R., Kumar, H., Kumar, V., Kaushik, R., and Kumar, A. P. (2022). Bioactive compounds in Ficus fruits, their bioactivities, and associated health benefits: a review. Journal of Food Quality 2022, 1-19.
Wang, H., Huang, H., Shang, Y., Song, M., and Ma, H. (2022). Identification and characterization of auxin response factor (ARF) family members involved in fig (Ficus carica L.) fruit development. PeerJ 10, e13798.
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Copyright (c) 2023 S CHANDIO , B GHAFAR , M ASIF , NZ MANGI , R ZAREEN , FH MANGI , SA MEMON
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