Frequency of Hyponatremia in Ischemic Stroke Patients Admitted in Medical Unit, MTI DHQ Dera Ismail Khan
DOI:
https://doi.org/10.54112/bcsrj.v6i5.2312Keywords:
Hyponatremia, ischaemic stroke, serum sodium, electrolyte disturbanceAbstract
Hyponatremia is a common electrolyte disturbance in acute stroke and may influence clinical monitoring and management. Early identification of low serum sodium is relevant in ischemic stroke patients admitted to medical units. Objective: To determine the frequency of hyponatremia in ischemic stroke patients admitted to the medical unit. Methods: This study included 121 patients aged 35 to 80 years, of either gender, presenting with ischemic stroke from 24 November 2024 to 24 March 2025 at the Department of Medicine, MTI DHQ Teaching Hospital, Dera Ismail Khan. Patients with previous stroke, hemorrhagic stroke, brain tumor, cerebral abscess, tuberculomas, those on medications including diuretics, steroids, antidepressants, antipsychotics, carbamazepine, or non-steroidal anti-inflammatory drugs, and patients with renal failure or severe hyperglycaemia > 300 mg/dl were excluded. Blood samples were collected from all patients to assess hyponatremia, defined as a serum sodium level < 135 mmol/L. Data were analyzed using SPSS 25. Results: The mean age of 121 patients in this study was 57.02±12.56 years. Male patients were 81 (66.9%), while female patients were 40 (33.1%). The mean duration of stroke was 33.26±4.51 hours, and the mean serum sodium level was 136.98±7.24 mmol/L. Hyponatremia was observed in 40 (33.1%) cases. Conclusion: It is concluded that the frequency of hyponatremia in patients presenting with ischemic stroke was 33.1%. Routine screening of serum sodium at admission is recommended for all ischemic stroke patients.
Downloads
References
1. Chandrabhatla AS, Kuo EA, Sokolowski JD, Kellogg RT, Park M, Mastorakos P. Artificial intelligence and machine learning in the diagnosis and management of stroke: a narrative review of United States Food and Drug Administration-approved technologies. J Clin Med. 2023;12(11):3755. DOI: https://doi.org/10.3390/jcm12113755
2. Soun JE, Chow DS, Nagamine M, Takhtawala RS, Filippi CG, Yu W, et al. Artificial intelligence and acute stroke imaging. AJNR Am J Neuroradiol. 2021;42(1):2-11. DOI: https://doi.org/10.3174/ajnr.A6883
3. Kelly DM, Engelbertz C, Rothwell PM, Anderson CD, Reinecke H, Koeppe J. Age- and sex-specific analysis of stroke hospitalization rates, risk factors, and outcomes from German nationwide data. Stroke. 2024;55(9):2284-2294. DOI: https://doi.org/10.1161/STROKEAHA.123.046118
4. Campbell BCV, De Silva DA, Macleod MR, Coutts SB, Schwamm LH, Davis SM, et al. Ischaemic stroke. Nat Rev Dis Primers. 2019;5(1):70. DOI: https://doi.org/10.1038/s41572-019-0118-8
5. Wu F, Zhang Z, Ma S, He Y, He Y, Ma L, et al. Microenvironment-responsive nanosystems for ischemic stroke therapy. Theranostics. 2024;14(14):5571-5595. DOI: https://doi.org/10.7150/thno.99822
6. Cui P, McCullough LD, Hao J. Brain to periphery in acute ischemic stroke: mechanisms and clinical significance. Front Neuroendocrinol. 2021;63:100932. DOI: https://doi.org/10.1016/j.yfrne.2021.100932
7. Xian Y, Li S, Jiang T, Beon CD, Poudel R, Thomas K, et al. Twenty years of sustained improvement in quality of care and outcomes for patients hospitalized with stroke or transient ischemic attack: data from the Get With The Guidelines-Stroke Program. Stroke. 2024;55(11):2599-2610. DOI: https://doi.org/10.1161/STROKEAHA.124.048174
8. Liamis G, Barkas F, Megapanou E, Christopoulou E, Makri A, Makaritsis K, et al. Hyponatremia in acute stroke patients: pathophysiology, clinical significance, and management options. Eur Neurol. 2019;82(1-3):32-40. DOI: https://doi.org/10.1159/000504475
9. Shima S, Niimi Y, Moteki Y, Takahashi O, Sato S, Inoue T, et al. Prognostic significance of hyponatremia in acute stroke: a systematic review and meta-analysis. Cerebrovasc Dis. 2020;49(5):531-539. DOI: https://doi.org/10.1159/000510751
10. Jamil Ur Rahman, Ahmad T, Shakir Ullah, Hussain M, Haleem Ur Rahman, Bashar N. Frequency of hyponatremia in patients with acute stroke in Ayub Teaching Hospital Abbottabad. Indus J Biosci Res. 2025;3(4):1256-1260. DOI: https://doi.org/10.70749/ijbr.v3i4.2921
11. Kidwai AA, Ara J, Rasheed SA, Najeebullah, Paracha S. Impact of hyponatremia on outcome of acute ischemic stroke in a tertiary care hospital. Professional Med J. 2019;26(10):1789-1793. DOI: https://doi.org/10.29309/TPMJ/2019.26.10.4142
12. Khan Z, Iqbal S, Ahmed F, Ahmad A. Characterization of hyponatremia in patients with ischemic stroke. J Med Sci. 2024;32(1):82-84. DOI: https://doi.org/10.52764/jms.24.32.1.15
13. Zafar M, Jalil A, Ghaffer A, Yousaf M, Batool S. Hyponatremia in ischemic stroke patients and its relationship to clinical outcomes in such patients. J Rawalpindi Med Coll. 2024;28(4):603-608. DOI: https://doi.org/10.37939/jrmc.v28i4.2560
14. Khan A, Khan Z, Khan S, Ullah A, Ayub G, Tariq MN. Frequency of hyponatremia and its impact on prognosis in ischemic stroke. Cureus. 2023;15(6). DOI: https://doi.org/10.7759/cureus.40317
Downloads
Published
How to Cite
License
Copyright (c) 2025 Saeed Anwar, Abdur Rehman, Taimoor Khan Sikandari, Muhammad Shafiq, Amir Inayat Khan

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.





