Diagnostic Accuracy of Ultrasonography in Diagnosing Uterine Adenomyosis Using Magnetic Resonance Imaging as the Gold Standard

Authors

  • Sara Islam Department of Diagnostic Radiology, Lady Reading Hospital, Peshawar, Pakistan
  • Nadeem Ullah Department of Diagnostic Radiology, Lady Reading Hospital, Peshawar, Pakistan

DOI:

https://doi.org/10.54112/bcsrj.v6i5.2277

Keywords:

Adenomyosis; Diagnostic accuracy; Magnetic resonance imaging; Transvaginal ultrasound; Uterine diseases.

Abstract

Uterine adenomyosis is a common benign gynecological disorder that may present with dysmenorrhea, abnormal uterine bleeding, and chronic pelvic pain. Magnetic resonance imaging is considered a reliable reference standard, while ultrasonography remains a widely available first-line diagnostic modality. Objective: To determine the diagnostic accuracy of ultrasonography in diagnosing of uterine adenomyosis keeping magnetic resonance imaging as gold standard. Methods: This study was conducted on 215 females aged 18 to 45 years with suspected adenomyosis. Patients who had recent uterine surgery, uterine fibroids, pelvic inflammatory disease, and tubal pathology were excluded from the study. All patients underwent transvaginal ultrasound, which was followed by pelvic MRI. Diagnostic accuracy including sensitivity, specificity, positive predictive value, and negative predictive value, were calculated using a 2×2 contingency table, keeping the MRI as gold standard. SPSS 25 was used for analysis. Stratification was performed using chi square test, keeping significance level at 5%. Results: The mean age of 215 patients in this study was 30.17±7.84 years and their mean body mass index was 26.86±2.65 kg/m2. MRI showed positive adenomyosis in 136 patients (63.3%), which ultrasound was positive for adenomyosis in 115 (53.5%) patients. Ultrasonography exhibited sensitivity of 69.12%, specificity 73.42%, positive predictive value of 81.74%, negative predictive value 58.00%, and diagnostic accuracy 70.70%. Conclusion: The diagnostic accuracy of ultrasonography in diagnosing uterine adenomyosis keeping magnetic resonance imaging as gold standard was 70.70%, with sensitivity 69.12% and specificity 73.42%.

Downloads

Download data is not yet available.
311

References

1. Moustafa BE, Hamed A, Moustafa AM. Recognizing the spectrum of sonographic presentations of adenomyosis in the peri-menopausal women underwent hysterectomy. Scientific Journal of Medical Scholar. 2021;2021(2):43-50. DOI: https://doi.org/10.55675/sjms.v2021i2.95

2. Harmsen MJ, Trommelen LM, de Leeuw RA, Tellum T, Juffermans LJM, Griffioen AW, et al. Uterine junctional zone and adenomyosis: comparison of MRI, transvaginal ultrasound and histology. Ultrasound Obstet Gynecol. 2023;62(1):42-60. DOI: https://doi.org/10.1002/uog.26117

3. Chapron C, Vannuccini S, Santulli P, Abrão MS, Carmona F, Fraser IS, et al. Diagnosing adenomyosis: an integrated clinical and imaging approach. Hum Reprod Update. 2020;26(3):392-411. DOI: https://doi.org/10.1093/humupd/dmz049

4. Bourdon M, Santulli P, Marcellin L, Maignien C, Maitrot-Mantelet L, Bordonne C, et al. Adenomyosis: an update regarding its diagnosis and clinical features. J Gynecol Obstet Hum Reprod. 2021;50(10):102228. DOI: https://doi.org/10.1016/j.jogoh.2021.102228

5. Choi EJ, Cho SB, Lee SR, Lim YM, Jeong K, Moon HS, et al. Comorbidity of gynecological and non-gynecological diseases with adenomyosis and endometriosis. Obstet Gynecol Sci. 2017;60(6):579-586. DOI: https://doi.org/10.5468/ogs.2017.60.6.579

6. Yamaguchi M, Yoshihara K, Suda K, Nakaoka H, Yachida N, Ueda H, et al. Three-dimensional understanding of the morphological complexity of the human uterine endometrium. iScience. 2021;24(4):102258. DOI: https://doi.org/10.1016/j.isci.2021.102258

7. Champaneria R, Abedin P, Daniels J, Balogun M, Khan KS. Ultrasound scan and magnetic resonance imaging for the diagnosis of adenomyosis: systematic review comparing test accuracy. Acta Obstet Gynecol Scand. 2010;89(11):1374-1384. DOI: https://doi.org/10.3109/00016349.2010.512061

8. Chapron C, Tosti C, Marcellin L, Bourdon M, Lafay-Pillet MC, Millischer AE, et al. Relationship between the magnetic resonance imaging appearance of adenomyosis and endometriosis phenotypes. Hum Reprod. 2017;32(7):1393-1401. DOI: https://doi.org/10.1093/humrep/dex088

9. Sam M, Raubenheimer M, Manolea F, Aguilar H, Mathew RP, Patel VH, et al. Accuracy of findings in the diagnosis of uterine adenomyosis on ultrasound. Abdom Radiol (NY). 2020;45(3):842-850. DOI: https://doi.org/10.1007/s00261-019-02231-9

10. Tariq M, Anwar J, Amin N, Gul B, Niaz A, Nawaz KH. Diagnostic accuracy of ultrasound and MRI for diagnosis of adenomyosis taking histopathology as gold standard. Pak Armed Forces Med J. 2022;72(Suppl 2):S346-S349. DOI: https://doi.org/10.51253/pafmj.v72iSUPPL-2.8064

11. Gallo R, Kamberaj L, Baroni A, De Cicco Nardone A, Scambia G, Masciullo V. Advances in non-invasive diagnosis of uterine adenomyosis: a narrative review. Gynecol Pelvic Med. 2025;8:13. DOI: https://doi.org/10.21037/gpm-24-52

12. Shaikh A, Masroor I, Masood A, Saeed SA. Diagnostic accuracy of transvaginal ultrasound in adenomyosis taking MRI as a gold standard. J Coll Physicians Surg Pak. 2023;33(10):1118-1123. DOI: https://doi.org/10.29271/jcpsp.2023.10.1118

13. Anjum A, Umbreen S, Nadeem MF, Noureen F, Asim F, Anwar S. Sonography and magnetic resonance imaging for the diagnosis of adenomyosis: comparison with histopathology. J Islamabad Med Dental Coll. 2024;13(4):638-645. DOI: https://doi.org/10.35787/jimdc.v13i4.1030

14. Maudot C, Vernet T, Debras E, Fernandez H, Capmas P. Diagnostic accuracy study of sonography in adenomyosis: a study of current practice. J Gynecol Obstet Hum Reprod. 2023;52(7):102604. DOI: https://doi.org/10.1016/j.jogoh.2023.102604

15. Rohini A, Nambiar J, Hebbar S. Diagnostic accuracy of ultrasound in the diagnosis of adenomyosis. J South Asian Feder Obst Gynaecol. 2024;16(6):641-643. DOI: https://doi.org/10.5005/jp-journals-10006-2547

Downloads

Published

2025-05-31

How to Cite

1.
Islam S, Ullah N. Diagnostic Accuracy of Ultrasonography in Diagnosing Uterine Adenomyosis Using Magnetic Resonance Imaging as the Gold Standard. Biol Clin Sci Res J [Internet]. 2025 May 31 [cited 2026 Jun. 29];6(5):464-7. Available from: https://bcsrj.com/ojs/index.php/bcsrj/article/view/2277

Issue

Section

Original Research Articles

Categories

Similar Articles

<< < 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 > >> 

You may also start an advanced similarity search for this article.