Colorectal Cancer Prognosis: Combined Role of Preoperative Prognostic Nutritional Index, D-Dimer Score, and Surgical Outcomes

Tayram  Khalid; Farhan  Zaheer; Syeda  Mahjabeen; Hafiz Yahya  Iftikhar; Sehrish  Alam; Syeda Zubaria  Qamar

doi:10.54112/bcsrj.v6i6.2016

Authors

Tayram Khalid Department of Surgery, Dr Ruth K M Pfau Chk Karachi, Pakistan
Farhan Zaheer Department of Surgery, Dow University of Health Sciences, Karachi, Pakistan
Syeda Mahjabeen Department of Surgery, Dr Ruth K M Pfau Chk Karachi, Pakistan
Hafiz Yahya Iftikhar Department of Surgery, Dr Ruth K M Pfau Chk Karachi, Pakistan
Sehrish Alam Department of Surgery, Dow University of Health Sciences, Karachi, Pakistan
Syeda Zubaria Qamar Department of Surgery, Dow University of Health Sciences, Karachi, Pakistan

DOI:

https://doi.org/10.54112/bcsrj.v6i6.2016

Keywords:

Colorectal cancer, Prognostic Nutritional Index, D-dimer, survival, prognosis

Abstract

Colorectal cancer (CRC) remains one of the leading causes of cancer mortality worldwide. Identification of reliable preoperative prognostic markers is vital for individualised patient care. This study investigated the predictive value of the composite Prognostic Nutritional Index (PNI) and D-dimer Score (PDS) for overall survival in patients with CRC. Methods: A prospective cohort study was conducted at Dr Ruth Pfao Civil Hospital, Karachi, from January 2023 to July 2024. Patients aged 40–80 years with confirmed CRC and available preoperative albumin, lymphocyte count, and D-dimer levels were included. Kaplan–Meier survival analysis and log-rank tests were applied. Results: Among 100 patients (mean age 61.6±13.3 years, 57% male), 69% were alive at a mean follow-up of 30.5±16.7 months. Age >60 years showed borderline association with reduced survival (p=0.05). No significant survival differences were found across PDS categories (log-rank χ²=1.760, p=0.415). Conclusion: The PDS was not independently associated with overall survival in this cohort. Broader multicentre studies are warranted to clarify its prognostic role.

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