COMPARATIVE ANALYSIS OF RENAL PROFILE AND SERUM ELECTROLYTES AMONG DIABETIC AND NON DIABETIC GROUPS IN DISTRICT PESHAWAR KP

Authors

  • . ABDULLAH 1Department of Health and Biological Science Abasyn University Peshawar, Pakistan
  • FE AMIN Department of Health and Biological Science Abasyn University Peshawar, Pakistan
  • K KHAN Department of Health and Biological Science Abasyn University Peshawar, Pakistan
  • A REHMAN Department of Health and Biological Science Abasyn University Peshawar, Pakistan
  • SJA SHAH Al-khidmat blood bank & diagnostic center Peshawar, Pakistan
  • MK AZAM Al-khidmat blood bank & diagnostic center Peshawar, Pakistan
  • AU REHMAN Department of Health and Biological Science Abasyn University Peshawar, Pakistan
  • F KHAN Department of Health and Biological Science Abasyn University Peshawar, Pakistan

DOI:

https://doi.org/10.54112/bcsrj.v2024i1.796

Keywords:

Creatinine, Diabetes Mellitus, Electrolytes, Hyperglycemia, Urea

Abstract

Diabetes mellitus is a prevalent non-communicable disease worldwide, contributing significantly to morbidity and mortality. Renal complications are a significant concern in diabetes, with hyperglycemia exacerbating renal dysfunction. Objective: This study aimed to assess renal function and electrolyte balance in diabetic and non-diabetic individuals, focusing on serum urea, creatinine levels, and electrolyte imbalances. Methods: This study was conducted at Al-Khidmat Hospital and processed at the MLT Skill Lab at Abasyn University, Peshawar. A total of 100 participants were enrolled, including diabetic and non-diabetic subjects. Blood samples were collected using a questionnaire design. Renal function tests (RFTs) were analysed using a biochemistry analyser, and serum electrolytes were assessed using an Electrolytes Analyzer. Data collection duration, methodology, and statistical analysis methods were employed. Results: Among the participants, individuals aged 40 to 70 in both genders exhibited a higher prevalence of elevated urea and creatinine levels, particularly in diabetic patients. Diabetic individuals showed a significant association with azotemia. Electrolyte imbalances, notably hypokalemia, were observed, indicating potential complications in diabetic patients. Conclusion: The study highlights the importance of proactive management strategies to mitigate renal complications in diabetic individuals. Comprehensive monitoring of renal function and electrolyte balance is essential in clinical practice.

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References

Kocher T, König J, Borgnakke WS, Pink C, Meisel P. Periodontal complications of hyperglycemia/diabetes mellitus: Epidemiologic complexity and clinical challenge. Periodontology 2000. 2018;78(1):59-97.

Oguntibeju OO. Type 2 diabetes mellitus, oxidative stress and inflammation: examining the links. International journal of physiology, pathophysiology and pharmacology. 2019;11(3):45.

Mohajan D. Historical View of Diabetics Mellitus: From Ancient Egyptian Polyuria to Discovery of Insulin. 2023.

Vecchio I, Tornali C, Bragazzi NL, Martini M. The discovery of insulin: an important milestone in the history of medicine. Frontiers in endocrinology. 2018;9:613.

Pradeepa R, Mohan V. Epidemiology of type 2 diabetes in India. Indian journal of ophthalmology. 2021;69(11):2932-8.

Wetmore JB, Collins AJ. Global challenges posed by the growth of end-stage renal disease. Renal Replacement Therapy. 2016;2:1-7.

Flatt AJ, Greenbaum CJ, Shaw JA, Rickels MR. Pancreatic islet reserve in type 1 diabetes. Annals of the New York Academy of Sciences. 2021;1495(1):40-54.

Massoud A, Massoud AH. Immunologic and genetic factors in type 1 diabetes mellitus. Autoimmune Diseases-Contributing Factors, Specific Cases of Autoimmune Diseases, and Stem Cell and Other Therapies: IntechOpen; 2012.

Flyvbjerg A. The role of the complement system in diabetic nephropathy. Nature Reviews Nephrology. 2017;13(5):311-8.

Sagoo MK, Gnudi L. Diabetic nephropathy: an overview. Diabetic nephropathy: methods and protocols. 2020:3-7.

Papadopoulou-Marketou N, Kanaka-Gantenbein C, Marketos N, Chrousos GP, Papassotiriou I. Biomarkers of diabetic nephropathy: A 2017 update. Critical reviews in clinical laboratory sciences. 2017;54(5):326-42.

Khanduker S, Ahmed R, Khondker F, Aharama A, Afrose N, Chowdhury M. Electrolyte disturbances in patients with diabetes mellitus. Bangladesh J Med Biochem. 2017;10(1):27-35.

Grover A, Sharma K, Gautam S, Gautam S, Gulati M, Singh SK. Diabetes and its complications: Therapies available, anticipated and aspired. Current Diabetes Reviews. 2021;17(4):397-420.

Roumelioti M-E, Ing TS, Rondon-Berrios H, Glew RH, Khitan ZJ, Sun Y, et al. Principles of quantitative water and electrolyte replacement of losses from osmotic diuresis. International urology and nephrology. 2018;50:1263-70.

Khan RN, Saba F, Kausar SF, Siddiqui MH. Pattern of electrolyte imbalance in Type 2 diabetes patients: Experience from a tertiary care hospital. Pakistan Journal of Medical Sciences. 2019;35(3):797.

Ramadan RH, Abdullah AM. Assessment of Serum Electrolyte Levels & HbA1C Levels among Type 2 Diabetic Sudanese Patients with Macrovascular Complications in Khartoum State. Open Access Library Journal. 2020;7(3):1-9.

Unachukwu M, Engwa G, Nwalo FN, Attama T-JC, Abonyi C, Akaniro-Ejim EN, et al. Influence of type 2 diabetes on serum electrolytes and renal function indices in patients. Journal of Clinical and Diagnostic Research. 2018;12(6).

Chutani A, Pande S. Correlation of serum creatinine and urea with glycemic index and duration of diabetes in Type 1 and Type 2 diabetes mellitus: A comparative study. National journal of physiology, pharmacy and pharmacology. 2017;7(9):914.

Sirivole M, Eturi S. A study on blood urea and serum creatinine in diabetes mellitus from Sangareddy District, Telangana, India. International Journal of Medical and Health Research. 2017;3(12):132-6

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Published

2024-05-08

How to Cite

ABDULLAH, ., AMIN, F., KHAN, K., REHMAN, A., SHAH, S., AZAM, M., REHMAN, A., & KHAN, F. (2024). COMPARATIVE ANALYSIS OF RENAL PROFILE AND SERUM ELECTROLYTES AMONG DIABETIC AND NON DIABETIC GROUPS IN DISTRICT PESHAWAR KP. Biological and Clinical Sciences Research Journal, 2024(1), 796. https://doi.org/10.54112/bcsrj.v2024i1.796

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