COMPARATIVE ANALYSIS OF RENAL PROFILE AND SERUM ELECTROLYTES AMONG DIABETIC AND NON DIABETIC GROUPS IN DISTRICT PESHAWAR KP

Authors

  • . ABDULLAH 1Department of Health and Biological Science Abasyn University Peshawar, Pakistan
  • FE AMIN Department of Health and Biological Science Abasyn University Peshawar, Pakistan
  • K KHAN Department of Health and Biological Science Abasyn University Peshawar, Pakistan
  • A REHMAN Department of Health and Biological Science Abasyn University Peshawar, Pakistan
  • SJA SHAH Al-khidmat blood bank & diagnostic center Peshawar, Pakistan
  • MK AZAM Al-khidmat blood bank & diagnostic center Peshawar, Pakistan
  • AU REHMAN Department of Health and Biological Science Abasyn University Peshawar, Pakistan
  • F KHAN Department of Health and Biological Science Abasyn University Peshawar, Pakistan

DOI:

https://doi.org/10.54112/bcsrj.v2024i1.796

Keywords:

Creatinine, Diabetes Mellitus, Electrolytes, Hyperglycemia, Urea

Abstract

Diabetes mellitus is a prevalent non-communicable disease worldwide, contributing significantly to morbidity and mortality. Renal complications are a significant concern in diabetes, with hyperglycemia exacerbating renal dysfunction. Objective: This study aimed to assess renal function and electrolyte balance in diabetic and non-diabetic individuals, focusing on serum urea, creatinine levels, and electrolyte imbalances. Methods: This study was conducted at Al-Khidmat Hospital and processed at the MLT Skill Lab at Abasyn University, Peshawar. A total of 100 participants were enrolled, including diabetic and non-diabetic subjects. Blood samples were collected using a questionnaire design. Renal function tests (RFTs) were analysed using a biochemistry analyser, and serum electrolytes were assessed using an Electrolytes Analyzer. Data collection duration, methodology, and statistical analysis methods were employed. Results: Among the participants, individuals aged 40 to 70 in both genders exhibited a higher prevalence of elevated urea and creatinine levels, particularly in diabetic patients. Diabetic individuals showed a significant association with azotemia. Electrolyte imbalances, notably hypokalemia, were observed, indicating potential complications in diabetic patients. Conclusion: The study highlights the importance of proactive management strategies to mitigate renal complications in diabetic individuals. Comprehensive monitoring of renal function and electrolyte balance is essential in clinical practice.

Downloads

Download data is not yet available.

References

Kocher T, König J, Borgnakke WS, Pink C, Meisel P. Periodontal complications of hyperglycemia/diabetes mellitus: Epidemiologic complexity and clinical challenge. Periodontology 2000. 2018;78(1):59-97.

Oguntibeju OO. Type 2 diabetes mellitus, oxidative stress and inflammation: examining the links. International journal of physiology, pathophysiology and pharmacology. 2019;11(3):45.

Mohajan D. Historical View of Diabetics Mellitus: From Ancient Egyptian Polyuria to Discovery of Insulin. 2023.

Vecchio I, Tornali C, Bragazzi NL, Martini M. The discovery of insulin: an important milestone in the history of medicine. Frontiers in endocrinology. 2018;9:613.

Pradeepa R, Mohan V. Epidemiology of type 2 diabetes in India. Indian journal of ophthalmology. 2021;69(11):2932-8.

Wetmore JB, Collins AJ. Global challenges posed by the growth of end-stage renal disease. Renal Replacement Therapy. 2016;2:1-7.

Flatt AJ, Greenbaum CJ, Shaw JA, Rickels MR. Pancreatic islet reserve in type 1 diabetes. Annals of the New York Academy of Sciences. 2021;1495(1):40-54.

Massoud A, Massoud AH. Immunologic and genetic factors in type 1 diabetes mellitus. Autoimmune Diseases-Contributing Factors, Specific Cases of Autoimmune Diseases, and Stem Cell and Other Therapies: IntechOpen; 2012.

Flyvbjerg A. The role of the complement system in diabetic nephropathy. Nature Reviews Nephrology. 2017;13(5):311-8.

Sagoo MK, Gnudi L. Diabetic nephropathy: an overview. Diabetic nephropathy: methods and protocols. 2020:3-7.

Papadopoulou-Marketou N, Kanaka-Gantenbein C, Marketos N, Chrousos GP, Papassotiriou I. Biomarkers of diabetic nephropathy: A 2017 update. Critical reviews in clinical laboratory sciences. 2017;54(5):326-42.

Khanduker S, Ahmed R, Khondker F, Aharama A, Afrose N, Chowdhury M. Electrolyte disturbances in patients with diabetes mellitus. Bangladesh J Med Biochem. 2017;10(1):27-35.

Grover A, Sharma K, Gautam S, Gautam S, Gulati M, Singh SK. Diabetes and its complications: Therapies available, anticipated and aspired. Current Diabetes Reviews. 2021;17(4):397-420.

Roumelioti M-E, Ing TS, Rondon-Berrios H, Glew RH, Khitan ZJ, Sun Y, et al. Principles of quantitative water and electrolyte replacement of losses from osmotic diuresis. International urology and nephrology. 2018;50:1263-70.

Khan RN, Saba F, Kausar SF, Siddiqui MH. Pattern of electrolyte imbalance in Type 2 diabetes patients: Experience from a tertiary care hospital. Pakistan Journal of Medical Sciences. 2019;35(3):797.

Ramadan RH, Abdullah AM. Assessment of Serum Electrolyte Levels & HbA1C Levels among Type 2 Diabetic Sudanese Patients with Macrovascular Complications in Khartoum State. Open Access Library Journal. 2020;7(3):1-9.

Unachukwu M, Engwa G, Nwalo FN, Attama T-JC, Abonyi C, Akaniro-Ejim EN, et al. Influence of type 2 diabetes on serum electrolytes and renal function indices in patients. Journal of Clinical and Diagnostic Research. 2018;12(6).

Chutani A, Pande S. Correlation of serum creatinine and urea with glycemic index and duration of diabetes in Type 1 and Type 2 diabetes mellitus: A comparative study. National journal of physiology, pharmacy and pharmacology. 2017;7(9):914.

Sirivole M, Eturi S. A study on blood urea and serum creatinine in diabetes mellitus from Sangareddy District, Telangana, India. International Journal of Medical and Health Research. 2017;3(12):132-6

Downloads

Published

2024-05-08

How to Cite

ABDULLAH, ., AMIN, F., KHAN, K., REHMAN, A., SHAH, S., AZAM, M., REHMAN, A., & KHAN, F. (2024). COMPARATIVE ANALYSIS OF RENAL PROFILE AND SERUM ELECTROLYTES AMONG DIABETIC AND NON DIABETIC GROUPS IN DISTRICT PESHAWAR KP. Biological and Clinical Sciences Research Journal, 2024(1), 796. https://doi.org/10.54112/bcsrj.v2024i1.796