EFFECTS OF ORAL SODIUM BICARBONATE SUPPLEMENTATION ON NUTRITIONAL STATUS OF PATIENTS UNDERGOING MAINTENANCE HEMODIALYSIS

A RAFIQ; AR ARSHAD

doi:10.54112/bcsrj.v2023i1.446

Authors

A RAFIQ General Medicine- Combined Military Hospital, Peshawar, Pakistan
AR ARSHAD General Medicine- Combined Military Hospital, Peshawar, Pakistan

DOI:

https://doi.org/10.54112/bcsrj.v2023i1.446

Keywords:

Chronic kidney Disease, Hemodialysis, Sodium bicarbonate

Abstract

To determine the oral sodium bicarbonate supplementation effects on nutritional status of patients undergoing maintenance hemodialysis. In a Medicine department at Combined Military Hospital, Peshawar, a case-control study was carried on “14-October 2021 to 14-April 2022”. It enrolled patients of ESRD on MHD with low serum bicarbonate levels. Patients were allocated into two groups: an experimental group receiving oral sodium bicarbonate and a control group receiving standard care. Parameters such as mid-thigh circumference, serum bicarbonate, and serum albumin were assessed at baseline and after 3 months, with statistical analysis performed using an independent sample t-test. The intervention group had a notable elevation in serum bicarbonate levels (20.87±1.58 mmol/l) as compared to the control group (18.73±2.38 mmol/l) (P = 0.0001). Furthermore, it was observed that the intervention group had a noteworthy elevation in serum albumin levels after 3 months (4.40±0.28 g/l), as compared to the control group (3.77±0.30 g/l) (P = 0.0001). Additionally, there was a statistically significant rise in the average mid-thigh circumference among participants in the intervention group during the third month, in comparison to those of the control group (41.20±1.70 vs. 39.74±1.27 cm; P = 0.001). Oral sodium bicarbonate supplementation in patients on maintenance hemodialysis significantly increased serum bicarbonate level, serum albumin level and mid-thigh size.

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References

Abramowitz, M. K., Hostetter, T. H., & Melamed, M. L. (2011). Association of serum bicarbonate levels with gait speed and quadriceps strength in older adults. American journal of kidney diseases, 58(1), 29-38.

Abramowitz, M. K., Melamed, M. L., Bauer, C., Raff, A. C., & Hostetter, T. H. (2013). Effects of oral sodium bicarbonate in patients with CKD. Clinical journal of the American Society of Nephrology: CJASN, 8(5), 714.

Aigner, C., Cejka, D., Sliber, C., Fraunschiel, M., Sunder-Plassmann, G., & Gaggl, M. (2019). Oral sodium bicarbonate supplementation does not affect serum calcification propensity in patients with chronic kidney disease and chronic metabolic acidosis. Kidney and Blood Pressure Research, 44(2), 188-199.

Bakaloudi, D. R., Siargkas, A., Poulia, K. A., Dounousi, E., & Chourdakis, M. (2020). The effect of exercise on nutritional status and body composition in hemodialysis: a systematic review. Nutrients, 12(10), 3071.

Basile, C., Rossi, L., & Lomonte, C. (2018, November). Dialysate bicarbonate concentration: too much of a good thing?. In Seminars in dialysis, 31, 6: 576-582.

Bikbov, B., Perico, N., Remuzzi, G., & GBD Genitourinary Diseases Expert Group. (2018). Disparities in chronic kidney disease prevalence among males and females in 195 countries: analysis of the global burden of disease 2016 study. Nephron, 139(4), 313-318.

Bleyer, A., Hartman, J., Brannon, P. C., Reeves-Daniel, A., Satko, S. G., & Russell, G. (2006). Characteristics of sudden death in hemodialysis patients. Kidney international, 69(12), 2268-2273.

Brunelli, S. M., Du Mond, C., Oestreicher, N., Rakov, V., & Spiegel, D. M. (2017). Serum potassium and short-term clinical outcomes among hemodialysis patients: impact of the long interdialytic interval. American Journal of Kidney Diseases, 70(1), 21-29.

Copur, S., Sag, A. A., Afsar, B., Rossignol, P., Covic, A., & Kanbay, M. (2020). Complications of metabolic acidosis and alkalinizing therapy in chronic kidney disease patients: a clinician-directed organ-specific primer. International Urology and Nephrology, 52, 2311-2320.

de Brito-Ashurst, I., Varagunam, M., Raftery, M. J., & Yaqoob, M. M. (2009). Bicarbonate supplementation slows progression of CKD and improves nutritional status. Journal of the American Society of Nephrology: JASN, 20(9), 2075.

Di Iorio, B. R., Bellasi, A., Raphael, K. L., Santoro, D., Aucella, F., Garofano, L., ... & Capasso, G. (2019). Treatment of metabolic acidosis with sodium bicarbonate delays progression of chronic kidney disease: the UBI Study. Journal of nephrology, 32, 989-1001.

Jo, I. Y., Kim, W. J., Park, H. C., Choi, H. Y., Lee, J. E., & Lee, S. M. (2017). Effect of personalized nutritional counseling on the nutritional status of hemodialysis patients. Nutrients, 17(56):285-95.

Kourtellidou, S. I., Ashby, D. R., & Johansson, L. R. (2021). Oral sodium bicarbonate in people on haemodialysis: a randomised controlled trial. BMC nephrology, 22, 1-11.

Lamsal, J.(2020). Sat-065 Effects of oral sodium bicarbonate supplementation in nutritional parameters in patients undergoing maintenance hemodialysis treatment, An Interventional Comparative Study. Kidney International Reports 5: S28–S29.

Rasheed, Z. A., Al-Hashemi, B. A., & Ali, A. A. (2023). Effects of Oral Sodium Bicarbonate Supplementation on Protein Metabolism and Inflammation in Iraqi Hemodialysis Patients: An Open-Label Randomized Controlled Trial. International Journal of Nephrology, 2023:6657188.

Sabatino, A., Regolisti, G., Karupaiah, T., Sahathevan, S., Singh, B. S., Khor, B. H., ... & Fiaccadori, E. (2017). Protein-energy wasting and nutritional supplementation in patients with end-stage renal disease on hemodialysis. Clinical nutrition, 36(3), 663-671.

Sofia, A., Cappelli, V., Valli, A., & Garibotto, G. (2005). Metabolic acidosis in patients with chronic kidney diseases: why and when to treat it?. Giornale Italiano di Nefrologia: Organo Ufficiale Della Societa Italiana di Nefrologia, 22(1), 28-36.

Wiliyanarti, P. F., & Muhith, A. (2019). Life Experience of chronic kidney diseases undergoing hemodialysis therapy. NurseLine Journal, 4(1), 54-60.