EVIDENCE AND FREQUENCY OF NEWLY DIAGNOSED DIABETES MELLITUS IN THE PATIENTS ADMITTED WITH COVID-19 INFECTION

Authors

  • M AHMED Post graduate Resident- Medicine , Divisional Headquaters teaching Hospital Mirpur AJK, Pakistan
  • UB TARIQ Department of Medicine, Nawaz Sharif Medical College Gujrat, Pakistan
  • S AHSAN Senior Registrar-Medicine, Benazir Bhutto Hospital/Rawalpindi Medical University, Pakistan
  • T AROOJ Department of Botany, GC University Lahore, Pakistan
  • H SHABBIR Department of Forensic Medicine and Toxicology -PGMI Lahore, Pakistan
  • ZL BAIG Divisional Headquarters Teaching Hospital Mirpur AJK

DOI:

https://doi.org/10.54112/bcsrj.v2023i1.377

Keywords:

covid-19, diabetes mellitus, hyperglycemia

Abstract

To find out how often individuals with covid-19 infection develop new cases of diabetes mellitus. The study was conducted at Mirpur Azad Jammu and Kashmir Teaching Hospital, Divisional Headquarter of the Department of Medicine, from January 2021 to June 2021. Adult patients between 18 and 70, regardless of gender, who were diagnosed with the virus showing mild to moderate symptoms determined by RT-PCR test and were not previously reported with diabetes met the inclusion criteria. Within 24 hours of admission, 5cc of each patient's blood was drawn and sent for testing to determine the BSF, BSR, and HBA1C levels before commencing steroids. Data obtained were analyzed by using (SPSS) version 24.0. Total 130 patients of covid-19 were included who met the inclusion criteria. Mean age of patients was 39.60+ 9.76 years. There were 108 (83.1%) males and 22 (16.9%) females.Twenty-six patients (20%) were diagnosed with DM during admission. The mean age of patients in non-diabetic group was 39.75+ 9.5 years, while in diabetic group it was 51.38+ 12.74 years which was statistically significant (0.001). 24 (92.3%) patients with newly diagnosed DM had HBA1C levels of more than 6.5 which was statistically significant (0.001).We conclude that newly diagnosed DM  significantly relates to covid-19 infection. Elderly patients already in pre-diabetic state with increased HBA1C levels are more prone to develop DM after this viral infection.

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References

Abdi, A., Jalilian, M., Sarbarzeh, P.A., and Vlaisavljevic Z. (2020). Diabetes and COVID-19: A systematic review on the current evidence. Diabetes Res. Clin. Pract. 166, 108347.

Alaqeel, A., Aljuraibah, F., Alsuhaibani, M., Huneif, M., Alsaheel, A., Dubayee, M.A., Alsaedi, A., Bakkar, A., Alnahari, A., Taha, A., Alharbi, K. (2021). The impact of the COVID-19 pandemic lockdown on the incidence of new-onset type 1 diabetes and ketoacidosis among Saudi children. Front. Endocrinol. 12, 669302.

Apicella, M., Campopiano, M.C., Mantuano, M., Mazoni, L., Coppelli, A. and Del-Prato, S. (2020). COVID-19in people with diabetes: Understanding the reasons for worse outcomes. Lancet Diabetes Endocrinol. 8, 782–792.

Gentile, S., Strollo, F., Mambro, A., and Ceriello, A. (2020). COVID-19, ketoacidosis and new-onset diabetes: Are there possible cause and effect relationships among them? Diabetes Obes. Metab. 22, 2507–2508

Grasselli, G., Zangrillo, A., Zanella, A., Antonelli, M., Cabrini, L., Castelli, A., Cereda, D., Coluccello, A., Foti, G., Fumagalli, R., and Iotti, G. (2020). Baseline characteristics and outcomes of 1591 patients infected with SARS-CoV-2 admitted to ICUs of the Lombardy Region, Italy. JAMA. 323(16), 1574-81.

Guan, W.J., Ni, Z.Y., Hu, Y., Liang, W.H., Ou, C.Q., and He, J.X. (2020). Clinical characteristics of coronavirus disease 2019 in China. N Engl J Med 59, 62-81.

Li, J., Wang, X., Chen, J., Zuo, X., Zhang, H., and Deng, A. (2022). COVID-19infection may cause ketosis and ketoacidosis. Diabetes Obes. Meta. 22, 1935–1941

Lim, S., Bae, J.H., Kwon, H.S., and Nauck, M.A. (2021). COVID-19 and diabetes mellitus: from pathophysiology to clinical management. Nat Rev Endocrinol. 17, 11–30.

Maddaloni, E. and Buzzetti, R. (2020). COVID-19 and diabetes mellitus: Unveiling the interaction of two pandemics. Diabetes/Metab.Res.Rev. 36, 3321

Pearson-Stuttard, J., Blundell, S., Harris, T., Cook, D.G. and Critchley, J. (2016). Diabetes and infection: Assessing the association with glycaemic control in population-based studies. Lancet Diabetes Endocrinol. 4, 148–158.

Prete, M., Favoino, E., Catacchio, G., Racanelli, V. and Perosa, F. (2020). SARS-CoV-2 inflammatory syndrome. Clinical features and rationale for immunological treatment. Int. J. Mol. Sci. 2, 3377

Rahmati, M., Keshvari, M., Mirnasuri, S., Yon, D.K., Lee, S.W., Shin, J., and Smith, L. (2022). The global impact of COVID-19 pandemic on the incidence of pediatric new onset type 1 diabetes and ketoacidosis: A systematic review and meta analysis. J. Med. Virol. 94(11), 5112-27.

Sachs, J.D., Karim, S.S., Aknin, L., Allen, J., Brosbøl, K., Colombo, F., Barron, G.C., Espinosa, M.F., Gaspar, V., Gaviria, A., and Haines, A. (2022). The Lancet Commission on lessons for the future from the COVID-19pandemic. The Lancet. 400(10359), 1224-80.

Sathish, T., and Anton, M.C. (2021) Newly diagnosed diabetes in patients with mild to moderate COVID-19. Diabetes Metab. Syndr. Clin. Res. Rev. 15(2), 569-71.

Sathish, T., Kapoor, N., Cao, Y., Tapp, R.J., and Zimmet, P. (2021). Proportion of newly diagnosed diabetes in COVID-19patients: a systematic review and meta-analysis. Diabetes Obes. Metab. 23(3), 870.

Shrestha, D.B., Budhathoki, P., Raut, S., Adhikari, S., Ghimire, P., Thapaliya, S., Rabaan, A.A., and Karki, B.J. (2021). New-onset diabetes in COVID-19and clinical outcomes: A systematic review and meta-analysis. World J. Virol. 10(5), 275.

Smith, S.M., Boppana, A., Traupman, J.A., Unson, E., Maddock, D.A., Chao, K., Dobesh, D.P., Brufsky, A. and Connor, R.I. (2021). Impaired glucose metabolism in patients with diabetes, prediabetes, and obesity is associated with severe COVID-19. J Med Virol. 93, 409–415.

Suwanwongse, K., and Shabarek, N. (2021). Newly diagnosed diabetes mellitus, DKA, and COVID‐19: Causality or coincidence? A report of three cases. J. Med. Virol. 93(2), 1150-3.

Wang, Z., Du, Z., and Zhu, F. (2020). Glycosylated hemoglobin is associated with systemic inflammation, hypercoagulability, and prognosis of COVID-19patients. Diabetes Res. Clin. Pract. 164, 108214.

Wu, H., Lau, E.S.H., and Ma, R.C.W., (2020). Secular trends in all-cause and cause-specific mortality rates in people with diabetes in Hong Kong, 2001-2016: a retrospective cohort study. Diabetologia. 1, 35-49.

Zhang, Y., Cui, Y., Shen, M., Zhang, J., Liu, B., Dai, M., Chen, L., Han, D., Fan, Y., Zeng, Y., Li, W., Lin, F., Li, S., Chen, X., and Pan, P. (2020). Medical team from Xiangya Hospital to support Hubei. China Association of diabetes mellitus with disease severity and prognosis in COVID-19: A retrospective cohort study. Diabetes Res Clin Pract. 165, 108227

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Published

2023-06-22

How to Cite

AHMED , M., TARIQ , U., AHSAN , S., AROOJ , T., SHABBIR , H., & BAIG , Z. (2023). EVIDENCE AND FREQUENCY OF NEWLY DIAGNOSED DIABETES MELLITUS IN THE PATIENTS ADMITTED WITH COVID-19 INFECTION. Biological and Clinical Sciences Research Journal, 2023(1), 377. https://doi.org/10.54112/bcsrj.v2023i1.377