ASSESSMENT OF INFECTION RISK IN OLDER PATIENTS WITH PSORIASIS ON SYSTEMIC THERAPY

R IQBAL; MA ULLAH; S RAFIQUE

doi:10.54112/bcsrj.v2023i1.233

Authors

R IQBAL Department of Dermatology, unit-1, Jinnah Hospital, Lahore, Pakistan
MA ULLAH Department of Dermatology, Al-Aleem Medical College / Gulab Devi Teaching Hospital, Lahore, Pakistan
S RAFIQUE Department of Dermatology, Gulab Devi Teaching Hospital, Lahore, Pakistan

DOI:

https://doi.org/10.54112/bcsrj.v2023i1.233

Keywords:

Psoriasis, systemic treatment, infection, old age, phototherapy, tropical treatment

Abstract

Systemic treatment for psoriasis can be effective but have more risk of infection especially in old age groups. The aim of this study is to assess the infection risk in older patients with psoriasis on systemic therapy. A total of 639 patients were included in the study those were taking systemic therapy for psoriasis for last 6 months. They were divided into two groups. Group A with younger patients whereas the Group B had the older patients. Data was gathered and analyzed. Both groups were compared with respect to the incidence of infection. The results showed that that the group B had significantly high frequency of infection compared to the Group A. In conclusion, the assessment of infection risk in older patients with psoriasis who are receiving systemic therapies is crucial to ensure that patients receive the most appropriate and effective treatment while minimizing the risk of infections and other adverse events.

Downloads

Download data is not yet available.

References

Amatore, F., Villani, A. P., Tauber, M., Viguier, M., Guillot, B., and Dermatology, P. R. G. o. t. F. S. o. (2019). French guidelines on the use of systemic treatments for moderate‐to‐severe psoriasis in adults. Journal of the European Academy of Dermatology and Venereology 33, 464-483.

Bakirtzi, K., Sotiriou, E., Papadimitriou, I., Sideris, N., Vakirlis, E., Lallas, A., Vrani, F., and Ioannides, D. (2022). Elderly patients with psoriasis: long-term efficacy and safety of modern treatments. Journal of Dermatological Treatment 33, 1339-1342.

Fagni, F., Simon, D., Tascilar, K., Schoenau, V., Sticherling, M., Neurath, M. F., and Schett, G. (2021). COVID-19 and immune-mediated inflammatory diseases: effect of disease and treatment on COVID-19 outcomes and vaccine responses. The Lancet Rheumatology 3, e724-e736.

Gelfand, J. M., Wan, J., Duffin, K. C., Krueger, G. G., Kalb, R. E., Weisman, J. D., Sperber, B. R., Stierstorfer, M. B., Brod, B. A., and Schleicher, S. M. (2012). Comparative effectiveness of commonly used systemic treatments or phototherapy for moderate to severe plaque psoriasis in the clinical practice setting. Archives of dermatology 148, 487-494.

Her, M., and Kavanaugh, A. (2016). Alterations in immune function with biologic therapies for autoimmune disease. Journal of Allergy and Clinical Immunology 137, 19-27.

Hong, J. J., Mosca, M. L., Hadeler, E. K., Brownstone, N. D., Bhutani, T., and Liao, W. J. (2021). Genital and inverse/intertriginous psoriasis: An updated review of therapies and recommendations for practical management. Dermatology and therapy 11, 833-844.

Langley, R. G., Ho, V., Lynde, C., Papp, K. A., Poulin, Y., Shear, N., Toole, J., and Zip, C. (2005). Recommendations for incorporating biologicals into management of moderate to severe plaque psoriasis: individualized patient approaches. Journal of cutaneous medicine and surgery 9, 18-25.

Lazar, V., Ditu, L.-M., Pircalabioru, G. G., Gheorghe, I., Curutiu, C., Holban, A. M., Picu, A., Petcu, L., and Chifiriuc, M. C. (2018). Aspects of gut microbiota and immune system interactions in infectious diseases, immunopathology, and cancer. Frontiers in immunology 9, 1830.

Lu, Y., Chen, H., Nikamo, P., Low, H. Q., Helms, C., Seielstad, M., Liu, J., Bowcock, A. M., Stahle, M., and Liao, W. (2013). Association of cardiovascular and metabolic disease genes with psoriasis. The Journal of investigative dermatology 133, 836.

Mahil, S. K., Dand, N., Mason, K. J., Yiu, Z. Z., Tsakok, T., Meynell, F., Coker, B., McAteer, H., Moorhead, L., and Mackenzie, T. (2021). Factors associated with adverse COVID-19 outcomes in patients with psoriasis—insights from a global registry–based study. Journal of allergy and clinical immunology 147, 60-71.

Martin, G., Young, M., and Aldredge, L. (2019). Recommendations for initiating systemic therapy in patients with psoriasis. The Journal of Clinical and Aesthetic Dermatology 12, 13.

Nowowiejska, J., Baran, A., Grabowska, P., Lewoc, M., Kaminski, T. W., and Flisiak, I. (2022). Assessment of life quality, stress and physical activity among patients with psoriasis. Dermatology and Therapy 12, 395-406.

Singh, N., Sondhi, S., Jindal, S., Pandit, V., and Ashawat, M. S. (2020). Treatment and Management for patients with mild to severe Psoriasis: A Review. Asian Journal of Pharmaceutical Research 10, 286-292.