CO-EXISTENCE OF HELICOBACTER PYLORI IN GASTRIC AND GALLBLADDER MUCOSA IN CHOLECYSTITIS PATIENTS: A CROSS-SECTIONAL STUDY

MA RANA; A BHATTI; MS KHALID; S ASHRAF; MH SIDDIQUI; AHA AWAD; AM ABDELBAKY; WG ELMASRY; S HANIF

doi:10.54112/bcsrj.v2023i1.231

Authors

MA RANA Department of Critical Care Medicine, Amna Inayat Medical College & Bahria International Hospital, Lahore, Pakistan
A BHATTI Department of Gastroenterology & Hepatology, Bahria International Hospital, Lahore, Pakistan
MS KHALID Department of Gastroenterology, Continental Medical College, Lahore, Pakistan
S ASHRAF Department of Surgery, Bahria International Hospital, Lahore, Pakistan
MH SIDDIQUI Department of Medicine, Akhtar Saeed Medical & Dental College, Lahore, Pakistan
AHA AWAD Department of Intensive Care Medicine, Rashid Hospital, Dubai, United Arab Emirates
AM ABDELBAKY Department of Intensive Care Medicine, Rashid Hospital, Dubai, United Arab Emirates
WG ELMASRY Department of Intensive Care Medicine, Rashid Hospital, Dubai, United Arab Emirates
S HANIF Department of Medicine, Expert Doctor, PVT, LTD, Lahore, Pakistan

DOI:

https://doi.org/10.54112/bcsrj.v2023i1.231

Keywords:

Helicobacter pylori, Co-existence, Gastric mucosa, Gallbladder mucosa, cholecystitis

Abstract

This study was designed to assess the frequency of co-existence of H. Pylori in gastric and gallbladder mucosa of patients with acute cholecystitis or who had symptoms of cholelithiasis. This cross-sectional analysis was conducted at Bahria Town International Hospital Lahore from September 2020 to September 2021. The study consisted of 51 participants, all diagnosed with either acute cholecystitis or symptomatic cholelithiasis. Information regarding the patients' ages, genders, and the H. pylori existence in the mucosa of their gastric and gallbladders was collected and analyzed with SPSS version 22. H. pylori was discovered in the gallbladder mucosa of 22 individuals, which accounts for 43.1% of all cases, and in the gastric mucosa of 16 patients, which accounts for 31.1% of all cases. The co-existence of H. pylori in both the mucosa of the gallbladder and gastric wall was found in six (11.8%) patients. The co-existence of H pylori was significantly greater in patients with acute cholecystitis compared to those with cholelithiasis (p = 0.021). This study showed no significant relationship between age and smoking history with the co-existence of H. pylori in gastric and gallbladder mucosa. The findings of this study indicate that the presence of H. pylori infection is extensive in the gallbladder and stomach mucosa of the patients diagnosed with acute cholecystitis and cholelithiasis. When evaluating patients with gallbladder issues, it should be considered the presence of H. pylori in both the gallbladder and gastric mucosa.

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References

Cen, L., Pan, J., Zhou, B., Yu, C., Li, Y., Chen, W., and Shen, Z. (2018). Helicobacter Pylori infection of the gallbladder and the risk of chronic cholecystitis and cholelithiasis: A systematic review and meta‐analysis. Helicobacter 23, e12457.

Chmiela, M., Gajewski, A., and Rudnicka, K. (2015). Helicobacter pylori vs coronary heart disease-searching for connections. World journal of cardiology 7, 187.

De Graaf, M., Beck, R., Caccio, S. M., Duim, B., Fraaij, P. L., Le Guyader, F. S., Lecuit, M., Le Pendu, J., De Wit, E., and Schultsz, C. (2017). Sustained fecal-oral human-to-human transmission following a zoonotic event. Current opinion in virology 22, 1-6.

Debraekeleer, A., and Remaut, H. (2018). Future perspective for potential Helicobacter pylori eradication therapies. Future microbiology 13, 671-687.

Gravina, A. G., Zagari, R. M., De Musis, C., Romano, L., Loguercio, C., and Romano, M. (2018). Helicobacter pylori and extragastric diseases: A review. World journal of gastroenterology 24, 3204.

Hatton, G. B., Madla, C. M., Rabbie, S. C., and Basit, A. W. (2018). All disease begins in the gut: Influence of gastrointestinal disorders and surgery on oral drug performance. International Journal of Pharmaceutics 548, 408-422.

Hua, Y., Lou, Y.-X., Li, C., Sun, J.-Y., Sun, W., and Kong, X.-Q. (2021). Clinical outcomes of bariatric surgery—Updated evidence. Obesity Research & Clinical Practice.

Javanmard, A., Ashtari, S., Sabet, B., Davoodi, S. H., Rostami-Nejad, M., Akbari, M. E., Niaz, A., and Mortazavian, A. M. (2018). Probiotics and their role in gastrointestinal cancers prevention and treatment; an overview. Gastroenterology and hepatology from bed to bench 11, 284.

Joo, Y.-E., Park, H.-K., Myung, D.-S., Baik, G.-H., Shin, J.-E., Seo, G.-S., Kim, G. H., Kim, H. U., Kim, H. Y., and Cho, S.-I. (2013). Prevalence and risk factors of atrophic gastritis and intestinal metaplasia: a nationwide multicenter prospective study in Korea. Gut and liver 7, 303.

Kandulski, A., Selgrad, M., and Malfertheiner, P. (2008). Helicobacter pylori infection: a clinical overview. Digestive and Liver Disease 40, 619-626.

Liu, L.-P., Sheng, X.-P., Shuai, T.-K., Zhao, Y.-X., Li, B., and Li, Y.-M. (2018). Helicobacter pylori promotes invasion and metastasis of gastric cancer by enhancing heparanase expression. World Journal of Gastroenterology 24, 4565.

Pacifico, L., Osborn, J. F., Tromba, V., Romaggioli, S., Bascetta, S., and Chiesa, C. (2014). Helicobacter pylori infection and extragastric disorders in children: a critical update. World Journal of Gastroenterology: WJG 20, 1379.

Rugge, M., Capelle, L. G., Cappellesso, R., Nitti, D., and Kuipers, E. J. (2013). Precancerous lesions in the stomach: from biology to clinical patient management. Best Practice & Research Clinical Gastroenterology 27, 205-223.

Shah, S. C., Piazuelo, M. B., Kuipers, E. J., and Li, D. (2021). AGA clinical practice update on the diagnosis and management of atrophic gastritis: expert review. Gastroenterology 161, 1325-1332. e7.

Song, M., Chan, A. T., and Sun, J. (2020). Influence of the gut microbiome, diet, and environment on risk of colorectal cancer. Gastroenterology 158, 322-340.

Tang, H., Chen, W., Li, D., Duan, X., Ding, S., Zhao, M., and Zhang, J. (2019). Luminol-based ternary electrochemiluminescence nanospheres as signal tags and target-triggered strand displacement reaction as signal amplification for highly sensitive detection of Helicobacter pylori DNA. Sensors and Actuators B: Chemical 293, 304-311.

Thirumurthi, S., and Graham, D. Y. (2012). Helicobacter pylori infection in India from a western perspective. The Indian journal of medical research 136, 549.

Wang, D., Cheng, J., Zhang, J., Zhou, F., He, X., Shi, Y., and Tao, Y. (2021). The role of respiratory microbiota in lung cancer. International journal of biological sciences 17, 3646.