COMPARISON OF  DIAGNOSTIC VALUE OF  SHEAR WAVE ELASTOGRAPHY AND LIVER BIOPSY IN ASSESSING LIVER FIBROSIS

M ZAHRA; A ZAFAR; A KHALID; R AHMED; A BUKHARI

doi:10.54112/bcsrj.v2022i1.162

Authors

M ZAHRA Department of Pediatric Radiology, CH & ICH Multan, Pakistan
A ZAFAR Department of Radiology, Bakhtawar Amin Trust Hospital Multan, Pakistan
A KHALID Ittefaq Trust Hospital Lahore, Pakistan
R AHMED Department of Biochemistry, Independent Medical College Faisalabad, Pakistan
A BUKHARI Health Services Academy, Chief Coordinator and Center Head at Australian Diploma Family Medicine, Concept family Medicine Multan, Pakistan

DOI:

https://doi.org/10.54112/bcsrj.v2022i1.162

Keywords:

Shear wave elastography, liver biopsy, liver fibrosis

Abstract

This prospective study was designed to compare the specificity and sensitivity ofshear wave elastography(SWE) and liver biopsy in liver fibrosis staging. The study was conducted at Bakhtawar Amin Trust Hospital Multan from July 2021 to July 2022. The study was conducted on 90 patients who underwent liver biopsy due to pathologies, including congenital liver diseases or as possible liver donors. An experienced radiologist performs shear wave elastography. An experienced histopathologist assessed biopsy specimens. The mean age of the patients was 30 years. Out of 90 patients, 16 (17.7%) had Hep B or C, 20 (22.2%) were liver donors, and 54 (60%) had other liver diseases. Elastography results showed mean liver stiffness in F0–F1, F2, F3, and F4 stage fibrosis to 5.48 ± .52 kPa, 8.22 ± .42 kPa, 9.56 ± .32 kPa, and 12.41 ± 2.9kPa, respectively. Results of liver biopsy and SWE were significantly correlated (p=.0001).Shear wave elastography is an effective tool for the assessment of liver fibrosis.

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References

Abraldes, J. G., Bureau, C., Stefanescu, H., Augustin, S., Ney, M., Blasco, H., Procopet, B., Bosch, J., Genesca, J., and Berzigotti, A. (2016). Noninvasive tools and risk of clinically significant portal hypertension and varices in compensated cirrhosis: The “Anticipate” study. Hepatology64, 2173-2184.

Ali, Z. A., Zytoon, A. A., Elsakhawy, M. M., and Algamal, R. M. (2018). Real-time shear wave elastography for assessing liver fibrosis in patients with chronic hepatitis C. Menoufia Medical Journal31, 538.

Augustin, S., Pons, M., Maurice, J. B., Bureau, C., Stefanescu, H., Ney, M., Blasco, H., Procopet, B., Tsochatzis, E., and Westbrook, R. H. (2017). Expanding the Baveno VI criteria for the screening of varices in patients with compensated advanced chronic liver disease. Hepatology66, 1980-1988.

Barr, R. G., Wilson, S. R., Rubens, D., Garcia-Tsao, G., and Ferraioli, G. (2020). Update to the society of radiologists in ultrasound liver elastography consensus statement. Radiology296, 263-274.

Berzigotti, A., Ferraioli, G., Bota, S., Gilja, O. H., and Dietrich, C. F. (2018). Novel ultrasound-based methods to assess liver disease: The game has just begun. Digestive and liver disease50, 107-112.

Buchanan, R., and Sinclair, J. M. (2021). Alcohol use disorder and the liver. Addiction116, 1270-1278.

Cassinotto, C., Lapuyade, B., Guiu, B., Des Grottes, H. M., Piron, L., Merrouche, W., Irles-Depe, M., Molinari, N., and De Ledinghen, V. (2020). Agreement between 2-dimensional shear wave and transient elastography values for diagnosis of advanced chronic liver disease. Clinical Gastroenterology and Hepatology18, 2971-2979. e3.

Dietrich, C. F., Ferraioli, G., Sirli, R., Popescu, A., Sporea, I., Pienar, C., Kunze, C., Taut, H., Schrading, S., and Bota, S. (2019). General advice in ultrasound based elastography of pediatric patients. Medical Ultrasonography21, 315-326.

Jang, W., Jo, S., Song, J. S., Hwang, H. P., and Kim, S.-H. (2021). Comparison of diffusion-weighted imaging and MR elastography in staging liver fibrosis: a meta-analysis. Abdominal Radiology46, 3889-3907.

Kim, H.-s., and El-Serag, H. B. (2019). The epidemiology of hepatocellular carcinoma in the USA. Current gastroenterology reports21, 1-8.

Mercedes, R., Brown, J., Minard, C., Tsai, C. M., Devaraj, S., Munden, M., and Leung, D. (2020). A liver biopsy validation pilot study of shear wave elastography, APRI, FIB-4, and novel serum biomarkers for liver fibrosis staging in children with chronic viral hepatitis. Global Pediatric Health7, 2333794X20938931.

Miele, L., Zocco, M. A., Pizzolante, F., De Matthaeis, N., Ainora, M. E., Liguori, A., Gasbarrini, A., Grieco, A., and Rapaccini, G. (2020). Use of imaging techniques for non-invasive assessment in the diagnosis and staging of non-alcoholic fatty liver disease. Metabolism112, 154355.

Monti, L., Salsano, M., Candusso, M., Avolio, A. W., Soglia, G., Marino, M., Francalanci, P., Spada, M., and Toma, P. (2020). Diagnosis of acute rejection of liver grafts in young children using acoustic radiation force impulse imaging. American Journal of Roentgenology215, 1229-1237.

Popescu, A., Şirli, R., and Sporea, I. (2019). 2D shear wave elastography for liver fibrosis evaluation. In "Ultrasound Elastography". IntechOpen.

Tada, T., Kumada, T., Toyoda, H., Ito, T., Sone, Y., Okuda, S., Tsuji, N., Imayoshi, Y., and Yasuda, E. (2015). Utility of real‐time shear wave elastography for assessing liver fibrosis in patients with chronic hepatitis C infection without cirrhosis: comparison of liver fibrosis indices. Hepatology Research45, E122-E129.