COMPARATIVE EFFICACY OF METHYLPREDNISOLONE AND DEXAMETHASONE IN INTENSIVE CARE PATIENTS WITH SEVERE COVID-19: A PROSPECTIVE STUDY FROM PAKISTAN

Authors

  • MS HASHMI Department of Internal Medicine, Services Hospital, Lahore, Pakistan
  • H NAEEM King Edward Medical University, Lahore
  • A HUSSAIN Department of Cardiology. Punjab Institute of Cardiology, Lahore, Pakistan
  • GM ZAFAR 4Department of Pediatric Urology. University of Child Health Science, The Children Hospital, Lahore, Pakistan.
  • MA RAO King Edward Medical University, Lahore
  • HMS JEHANGIR Department of Emergency Medicine. King Edward Medical University, Lahore, Pakistan
  • HS KHOKHAR King Edward Medical University, Lahore.
  • S ZAHOOR Department of Cardiology. Punjab Institute of Cardiology, Lahore, Pakistan

DOI:

https://doi.org/10.54112/bcsrj.v2022i1.135

Keywords:

Severe COVID-19, Dexamethasone, Methylprednisolone, Mortality

Abstract

The study aimed to determine the comparative efficacy of dexamethasone and methylprednisolone in treating severely ill COVID-19 patients in terms of mortality. Using a quasi-experimental design, the study was conducted at Mayo Hospital, Lahore, from May 2021 to October 2021. A total of 148 patients, divided into two groups of 74 each (groups A and B), were included in the study. Group A was given 6mg of dexamethasone, while group B was given methylprednisolone 40mg twice daily for 10 days. All the collected data was analyzed using SPSS 26.0, and Chi-square was used to find the mortality association between the two groups. A p-value of less than 0.05 was considered significant. The results showed that the age and gender distribution for the methylprednisolone and dexamethasone groups were 56.89±13.3 (M=36, F=38) and 57.69±12.6 (M=38, F=36), respectively. In terms of mortality, 45 patients died in the methylprednisolone group, while 54 people died in the dexamethasone group. There was statistical significance regarding mortality in both groups (p=0.003). In conclusion, the study found that administering 40mg of methylprednisolone twice daily produced better outcomes than 6mg of dexamethasone once daily in treating severe COVID-19 patients in the hospital.

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Published

2022-09-30

How to Cite

HASHMI , M., NAEEM , H., HUSSAIN, A., ZAFAR, G., RAO, M., JEHANGIR , H., KHOKHAR, H., & ZAHOOR, S. (2022). COMPARATIVE EFFICACY OF METHYLPREDNISOLONE AND DEXAMETHASONE IN INTENSIVE CARE PATIENTS WITH SEVERE COVID-19: A PROSPECTIVE STUDY FROM PAKISTAN. Biological and Clinical Sciences Research Journal, 2022(1), 135. https://doi.org/10.54112/bcsrj.v2022i1.135

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