Comparison of Outcomes Following Severe TBI Between Pediatric and Adult Patients With Similar GCS and Pupil Parameters
DOI:
https://doi.org/10.54112/bcsrj.v6i6.1776Keywords:
Adults, peads, traumatic brain injury, outcomesAbstract
Severe traumatic brain injury (TBI) remains a leading cause of mortality and long-term disability across all age groups. Pediatric patients are often thought to have superior neuroplasticity, potentially yielding better outcomes compared to adults. However, limited data exist directly comparing age-stratified outcomes when initial injury severity is matched. Objective: To evaluate and compare outcomes following severe TBI between pediatric and adult patients with similar initial neurological severity, as defined by Glasgow Coma Scale (GCS) scores and pupil reactivity. Methods: This cross-sectional study was conducted at the Shaheed Mohtarma Benazir Bhutto Institute of Trauma, Karachi, from February 2025 to May 2025 after receiving ethical approval from the institutional review board. A total of 300 patients aged 0 to 55 years with severe TBI (GCS score 3–8 and Abbreviated Injury Scale [AIS] head score >3) were enrolled using consecutive non-probability sampling. Participants were stratified into pediatric (0–17 years) and adult (18–55 years) groups. Outcome categories included good recovery, moderate disability, severe disability, vegetative state, and death. Comparative analysis was performed using the chi-square test, with p<0.05 considered statistically significant. Results: Outcome distributions did not significantly differ between groups (p = 0.527). Among adults, 20% had good recovery, 23% moderate disability, 18% severe disability, 17% were vegetative, and 23% died. In the pediatric group, 24% achieved good recovery, 13% had moderate disability, 24% severe disability, 22% were vegetative, and 17% died. Imaging and recovery pattern variations were observed but did not affect overall outcome parity. Conclusion: When initial injury severity is controlled, pediatric and adult patients with severe TBI exhibit comparable short-term outcomes. These findings emphasize the need for standardized, age-inclusive neurocritical care protocols and challenge assumptions of age-dependent prognostication.
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References
Zuniga R, Vieira RCA, Solla DJF, Godoy DA, Kolias A, de Amorim RLO, et al. Long-term outcome of traumatic brain injury patients with initial GCS of 3-5. World neurosurgery: X. 2024;23:100361.
Schucht JE, Rakhit S, Smith MC, Han JH, Brown JB, Grigorian A, et al. Beyond Glasgow Coma Scale: Prehospital prediction of traumatic brain injury. Surgery. 2025;179:108893.
Blackwell LS, Grell R. Pediatric Traumatic Brain Injury: Impact on the Developing Brain. Pediatric Neurology. 2023;148:215-22.
Obasa AA, Olopade FE, Juliano SL, Olopade JO. Traumatic brain injury or traumatic brain disease: A scientific commentary. Brain Multiphysics. 2024;6:100092.
Malhotra AK, Patel B, Hoeft CJ, Shakil H, Smith CW, Jaffe R, et al. Association between trauma center type and mortality for injured children with severe traumatic brain injury. The journal of trauma and acute care surgery. 2024;96(5):777-84.
Balakrishnan B, VanDongen-Trimmer H, Kim I, Hanson SJ, Zhang L, Simpson PM, et al. GCS-Pupil Score Has a Stronger Association with Mortality and Poor Functional Outcome than GCS Alone in Pediatric Severe Traumatic Brain Injury. Pediatric neurosurgery. 2021;56(5):432-9.
Ambesi V, Miller C, Fitzgerald MC, Mitra B. The GCS-Pupils (GCS-P) score to assess outcomes after traumatic brain injury: a retrospective study. British journal of neurosurgery. 2024:1-4.
Albargi H, Alharbi RJ, Almuwallad A, Harthi N, Khormi Y, Kanthimathinathan HK, et al. Traumatic head injuries in children: demographics, injury patterns, and outcomes in Saudi Arabia. International Journal of Emergency Medicine. 2025;18(1):3.
Emami P, Czorlich P, Fritzsche FS, Westphal M, Rueger JM, Lefering R, et al. Impact of Glasgow Coma Scale score and pupil parameters on mortality rate and outcome in pediatric and adult severe traumatic brain injury: a retrospective, multicenter cohort study. Journal of neurosurgery. 2017;126(3):760-7.
Agrawal N, Iyer SS, Patil V, Kulkarni S, Shah JN, Jedge P. Comparison of admission GCS score to admission GCS-P and FOUR scores for prediction of outcomes among patients with traumatic brain injury in the intensive care unit in India. Acute and critical care. 2023;38(2):226-33.
Ambesi V, Charne M, C. FM, and Mitra B. The GCS-Pupils (GCS-P) score to assess outcomes after traumatic brain injury: a retrospective study. British journal of neurosurgery.1-4.
Figaji AA. Anatomical and Physiological Differences between Children and Adults Relevant to Traumatic Brain Injury and the Implications for Clinical Assessment and Care. Frontiers in neurology. 2017;Volume 8 - 2017.
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Copyright (c) 2025 Ramsha Nasir Obaid, Atiq Ahmad Khan, Irfan Ali Shah, Shiraz Ahmed, Shahida Shahnawaz, Syed Muhammad Moaaz Bin Sultan

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