EVALUATING DIAGNOSTIC VALUE OF MAGNETIC RESONANCE SPECTROSCOPY (MRS) FOR DIAGNOSIS OF MALIGNANT BREAST MASSES

ZU ISLAM; A FIRDOUS; M ZAHRA; MF MALIK; Z ZAFAR; U HASSAN

doi:10.54112/bcsrj.v2022i1.131

Authors

ZU ISLAM Department of Diagnostic Radiology, Ibne Sina Hospital & Multan Medical & Dental College Multan, Pakistan
A FIRDOUS Department of Diagnostic Radiology, Ibne Sina Hospital & Multan Medical & Dental College Multan, Pakistan
M ZAHRA CH & ICH Multan, Pakistan
MF MALIK Department of Diagnostic Radiology, Ibne Sina Hospital & Multan Medical & Dental College Multan, Pakistan
Z ZAFAR Department of Diagnostic Radiology, Ibne Sina Hospital & Multan Medical & Dental College Multan, Pakistan
U HASSAN Department of Diagnostic Radiology, Ibne Sina Hospital & Multan Medical & Dental College Multan, Pakistan

DOI:

https://doi.org/10.54112/bcsrj.v2022i1.131

Keywords:

Malignancy, Breast Cancer, Magnetic Resonance Spectroscopy

Abstract

To evaluate diagnostic value of magnetic resonance spectroscopy (MRS) for diagnosis of malignant breast masses. The study included 155 patients with breast lesions at Department of Radiology, CH & ICH Multan from January 2021 to June 2021.1.5 Tesla MR system was used for proton magnetic resonance spectroscopy (1H MRS). Consultant radiologist interpreted MR spectroscopy for distinguishing between benign and malignant lesions using histopathology as a gold standard. SPSS 20.0 was used for data analysis. Among 81 MRS positive cases, 76 had malignant lesions (True Positive) and 05 had no malignant lesion (False Positive) on histopathology. Among 74 MRS negative cases, 7 had malignancy on histopathology (False Negative), while 67 had no malignant lesion (True Negative) on histopathology. It was concluded that MRS has high sensitivity and accuracy for diagnosis of malignant breast lesions.

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References

Ahmadani, M. A. B., Bhatty, S., ul Abideen, Z., Yaseen, M. S., Laique, T., and Malik, J. (2020). Imaging in Breast Cancer: Use of Magnetic Resonance Spectroscopy. Cureus 12.

Barakzai, N., Mansoor, E., and Buccimazza, I. (2021). Is conservative management of fibroadenomas feasible? 5-year results from the Durban Breast Unit. South African Journal of Surgery 59, 41-46.

Bukhari, H., Ahmad, N., Shabbir, I., and Idrees, I. N. (2019). Diagnostic accuracy of magnetic resonance spectroscopy (mrs) in malignant breast lesions. PJR 29.

Galati, F., Luciani, M. L., Caramanico, C., Moffa, G., Catalano, C., and Pediconi, F. (2019). Breast magnetic resonance spectroscopy at 3 T in biopsy-proven breast cancers: does Choline peak correlate with prognostic factors? Investigative radiology 54, 767-773. DOI: https://doi.org/10.1097/RLI.0000000000000597

Gu, H., Cui, W., Luo, S., and Deng, X. (2022). Diagnostic Performance of Diffusion Kurtosis Imaging for Benign and Malignant Breast Lesions: A Systematic Review and Meta-Analysis. Applied Bionics and Biomechanics 2022. DOI: https://doi.org/10.1155/2022/2042736

Lima, Z. S., Ebadi, M. R., Amjad, G., and Younesi, L. (2019). Application of imaging technologies in breast cancer detection: a review article. Open Access Macedonian Journal of Medical Sciences 7, 838. DOI: https://doi.org/10.3889/oamjms.2019.171

Machado, R. B. (2018). Controversies in the Use and Periodicity of Mammography as a Screening Method for Breast Cancer. Vol. 40, pp. 169-170. SciELO Brasil. DOI: https://doi.org/10.1055/s-0038-1648218

Mohamed, R. E., Zytoon, H. A., and Amin, M. A. (2018). Diagnostic interplay of proton magnetic resonance spectroscopy and diffusion weighted images with apparent diffusion coefficient values in suspicious breast lesions. The Egyptian Journal of Radiology and Nuclear Medicine 49, 536-552. DOI: https://doi.org/10.1016/j.ejrnm.2018.01.002

Pediconi, F., and Galati, F. (2020). Breast cancer screening programs: does one risk fit all? Quantitative Imaging in Medicine and Surgery 10, 886. DOI: https://doi.org/10.21037/qims.2020.03.14

Rasheed, M., Urooj, S., Fatima, S., Mujahid, N., Shakir, T. M., and Jamil, M. (2022). The Accuracy of Magnetic Resonance Imaging in Diagnosing Malignant Breast Lesions. Pakistan Journal of Medical & Health Sciences 16, 1248-1248. DOI: https://doi.org/10.53350/pjmhs221621248

Runjjala, K., and Naidu, Y. T. Combined Mammographic and Sonomammographic Evaluation of Breast Masses.

Sharma, U., Agarwal, K., Hari, S., Mathur, S. R., Seenu, V., Parshad, R., and Jagannathan, N. R. (2019). Role of diffusion weighted imaging and magnetic resonance spectroscopy in breast cancer patients with indeterminate dynamic contrast enhanced magnetic resonance imaging findings. Magnetic Resonance Imaging 61, 66-72. DOI: https://doi.org/10.1016/j.mri.2019.05.032

Sharma, U., and Jagannathan, N. R. (2019). In vivo MR spectroscopy for breast cancer diagnosis. BJR| Open 1, 20180040. DOI: https://doi.org/10.1259/bjro.20180040

Sharma, U., and Jagannathan, N. R. (2022). Magnetic Resonance Imaging (MRI) and MR Spectroscopic Methods in Understanding Breast Cancer Biology and Metabolism. Metabolites 12, 295. DOI: https://doi.org/10.3390/metabo12040295

Siegel, R., Naishadham, D., and Jemal, A. (2018). Cancer statistics for hispanics/latinos. CA Cancer J Clin 68, 425-445. DOI: https://doi.org/10.3322/caac.21494

Thakur, S., and Bitencourt, A. (2022). MR spectroscopy. In "Advances in Magnetic Resonance Technology and Applications", Vol. 5, pp. 485-502. Elsevier. DOI: https://doi.org/10.1016/B978-0-12-822729-9.00003-5

Wu, L.-A., Yen, R.-F., Shih, T. T.-F., Chen, K.-L., and Wang, J. (2021). Diagnostic Performance of Proton Magnetic Resonance Spectroscopy and 18F-Fluorocholine PET to Differentiate Benign From Malignant Breast Lesions. Clinical Nuclear Medicine 46, 896-903. DOI: https://doi.org/10.1097/RLU.0000000000003869