SOCIO-DEMOGRAPHIC STUDIES OF CANCER PATIENTS IN TERMS OF MEDICINAL PLANTS AS NEW RISK FACTOR AT CANCER HOSPITAL NIMRA, JAMSHORO

ST QURESHI; S JUNEJO; S MALIK; SA MEMON; . SADIA

doi:10.54112/bcsrj.v2024i1.916

Authors

ST QURESHI Institute of Plant Sciences, University of Sindh Jamshoro, Pakistan
S JUNEJO Institute of Plant Sciences, University of Sindh Jamshoro, Pakistan
S MALIK Department of Zoology, University of Sindh Jamshoro, Pakistan
SA MEMON Nuclear Institute of Medicine and Radiotherapy (NIMRA) Jamshoro, Pakistan
. SADIA Institute of Plant Sciences, University of Sindh Jamshoro, Pakistan

DOI:

https://doi.org/10.54112/bcsrj.v2024i1.916

Keywords:

Alternative Medicine, Cancer, Genotoxicity, Medicinal Plants, Risk Factors, Socio-Demography

Abstract

Cancer is the third leading cause of mortality in Pakistan. Despite increased awareness about significant cancer risk factors and efforts to avoid them, cancer incidence continues to rise. This suggests that there may be other hidden physical and chemical agents responsible for cancer. Various plants used as long-term alternative medicine have recently been identified as genotoxic, capable of damaging DNA. Objective: This study aimed to identify medicinal plants with genotoxic potential and their association with cancer risk factors through a socio-demographic survey. Methods: This interview-based survey was conducted at the Nuclear Institute of Medicine & Radiotherapy (NIMRA) Cancer Hospital. The study included 109 cancer patients and was conducted over six months. Participants were categorized into four risk factor groups: other risk factors (ORF), other risk factors with medicinal plant (MP) intake (ORF+MPs), medicinal plants only (MPs), and only milk tea drinkers. Data were analyzed using descriptive statistics to determine the association between medicinal plant use and cancer incidence. Results: The survey revealed four risk factor categories: ORF, ORF+MPs, MPs, and tea. The highest number of cancer patients (49) were in the tea category, while the lowest (11) were in the MPs-only category. Among male cancer patients, 53% were ORF+MPs users, whereas 55% of female cancer patients were in the tea category. Most male and female MP users were older, less educated, unemployed or low-income, unmarried, and urban residents. Only 11 patients (8 female, three male) used 18 types of MPs for various health issues before their cancer diagnosis, with stomach gas being the most common problem. The duration of MP use ranged from 14 years to one month, and the interval between MP use and cancer diagnosis ranged from 10 to 1 year. Among female MP users, breast cancer was the most common, while each male MP user had different types of cancer (brain tumor, stomach cancer, and cheek cancer). The most frequently used MPs were beetroot (BR), pepper fruit (PF), and senna leaves (SL). Conclusion: Long-term intake of medicinal plants is more common in females and may constitute a new risk factor for cancer, particularly in individuals who do not interact with known risk factors. Genotoxicity tests on the identified medicinal plants are recommended.

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References

Mattiuzzi C, Lippi G. Current cancer epidemiology. Journal of epidemiology and global health. 2019;9(4):217-22.

Almas A, Awan S, Bloomfield G, Nisar MI, Siddiqi S, Ahmed A, et al. Opportunities and challenges to non-communicable disease (NCD) research and training in Pakistan: a qualitative study from Pakistan. BMJ open. 2022;12(12):e066460.

Fidler MM, Gupta S, Soerjomataram I, Ferlay J, Steliarova-Foucher E, Bray F. Cancer incidence and mortality among young adults aged 20–39 years worldwide in 2012: a population-based study. The lancet oncology. 2017;18(12):1579-89.

Lewandowska AM, Rudzki M, Rudzki S, Lewandowski T, Laskowska B. Environmental risk factors for cancer-review paper. Annals of Agricultural and Environmental Medicine. 2018;26(1):1-7.

Anwar S, Almatroudi A, Alsahli MA, Khan MA, Khan AA, Rahmani AH. Natural products: implication in cancer prevention and treatment through modulating various biological activities. Anti-Cancer Agents in Medicinal Chemistry (Formerly Current Medicinal Chemistry-Anti-Cancer Agents). 2020;20(17):2025-40.

Khokhar A, Sharma P. Role of Environmental Factors in Increased Cancer Incidences and Health Impacts. Biotechnological Innovations for Environmental Bioremediation: Springer; 2022. p. 671-723.

Biswas P, Polash SA, Dey D, Kaium MA, Mahmud AR, Yasmin F, et al. Advanced implications of nanotechnology in disease control and environmental perspectives. Biomedicine & Pharmacotherapy. 2023;158:114172.

Bøhn S-KH. Lifestyle and Adverse Effects in Selected Norwegian Cancer Patients and Survivors. 2020.

Van Wyk B-E, Wink M. Medicinal plants of the world: Cabi; 2018.

Akbar S. Handbook of 200 medicinal plants: a comprehensive review of their traditional medical uses and scientific justifications. 2020.

Lee KW, Ching SM, Hoo FK, Ramachandran V, Swamy MK. Traditional medicinal plants and their therapeutic potential against major cancer types. Anticancer Plants: Natural Products and Biotechnological Implements: Volume 2. 2018:383-410.

Bothma R, Bello B, Scorgie F. Socio-demographic Factors Associated with Retention of Female Sex Workers in Healthcare in Hillbrow and Pretoria Sex Worker Clinics 2020.

Duri K, Gumbo FZ, Munjoma PT, Chandiwana P, Mhandire K, Ziruma A, et al. The University of Zimbabwe College of Health Sciences (UZ-CHS) BIRTH COHORT study: rationale, design and methods. BMC infectious diseases. 2020;20:1-21.

Giorgi G, Arcangeli G, Perminiene M, Lorini C, Ariza-Montes A, Fiz-Perez J, et al. Work-related stress in the banking sector: a review of incidence, correlated factors, and major consequences. Frontiers in psychology. 2017;8:308542.

Mohan A, Huybrechts I, Michels N. Psychosocial stress and cancer risk: a narrative review. European Journal of Cancer Prevention. 2022;31(6):585-99.

Schabath MB, Cote ML. Cancer progress and priorities: lung cancer. Cancer epidemiology, biomarkers & prevention. 2019;28(10):1563-79.

Seretis A, Cividini S, Markozannes G, Tseretopoulou X, Lopez DS, Ntzani EE, et al. Association between blood pressure and risk of cancer development: a systematic review and meta-analysis of observational studies. Scientific reports. 2019;9(1):8565.

Cui C-j, Wang G-j, Yang S, Huang S-k, Qiao R, Cui W. Tissue Factor-bearing MPs and the risk of venous thrombosis in cancer patients: A meta-analysis. Scientific Reports. 2018;8(1):1675.

Stapleton M, Kubaski F, Mason RW, Yabe H, Suzuki Y, Orii KE, et al. Presentation and treatments for mucopolysaccharidosis type II (MPS II; Hunter syndrome). Expert opinion on orphan drugs. 2017;5(4):295-307.

LING T. AUTONOMY SUPPORT, MOTIVATIONS, VALUE AND NATURAL CONTENT BELIEF ON HERBAL MEDICINE PRODUCT CONSUMPTIONS AMONGST EMERGING ADULTS: Universiti Teknologi Malaysia; 2020.

Korniluk A, Koper-Lenkiewicz OM, Kamińska J, Kemona H, Dymicka-Piekarska V. Mean platelet volume (MPV): new perspectives for an old marker in the course and prognosis of inflammatory conditions. Mediators of inflammation. 2019;2019(1):9213074.

Connell LC, Mota JM, Braghiroli MI, Hoff PM. The rising incidence of younger patients with colorectal cancer: questions about screening, biology, and treatment. Current treatment options in oncology. 2017;18:1-20.

Sheffer L, Loewen PJ, Soroka S, Walgrave S, Sheafer T. Nonrepresentative representatives: An experimental study of the decision making of elected politicians. American Political Science Review. 2018;112(2):302-21.

Cox KD, Covernton GA, Davies HL, Dower JF, Juanes F, Dudas SE. Human consumption of microplastics. Environmental science & technology. 2019;53(12):7068-74.

Agnihotri N, Mukherjee S. Dr. Parvinder Khanuja.

Mohamed H. Factors Associated With Health Seeking and Utilization Behaviour among the Somali Community in Garissa County, Kenya 2020.

Acharya J. Knowledge, attitudes, beliefs and behaviour of mothers of young children related to healthy eating: comparing rural and urban perspectives in Nepal: Bournemouth University; 2018.

Teele DL, Kalla J, Rosenbluth F. The ties that double bind: social roles and women's underrepresentation in politics. American Political Science Review. 2018;112(3):525-41.

Choi Y, Lee G, Song IG, Kim OJ, Park SM. Prevalence of adverse birth outcomes and disparity of unmarried women in South Korea: a systematic review. Journal of Global Health Reports. 2018;2:e2018008.

Armini NKA, Kusumaningrum T, Sari AP. Theory of planned behaviour for cervical cancer prevention-view of husband support. Indian J Public Health Res Dev. 2019;10(8):2553-8.

Shelton TV. Herbs and Roots: Yale University Press; 2019.

Romm A. Botanical Medicine for Women's Health E-Book: Botanical Medicine for Women's Health E-Book: Elsevier Health Sciences; 2017.

Nguyen Q, Kim D-C. Reconsidering rural land use and livelihood transition under the pressure of urbanization in Vietnam: A case study of Hanoi. Land Use Policy. 2020;99:104896.

Stapleton M, Hoshina H, Sawamoto K, Kubaski F, Mason RW, Mackenzie WG, et al. Critical review of current MPS guidelines and management. Molecular Genetics and Metabolism. 2019;126(3):238-45.

Lee RP. Cultural tradition and health-seeking behaviour. The Principles and Practice of Primary Care and Family Medicine: CRC Press; 2018. p. 26-37.