NANOBIOTECHNOLOGY IN HEALTH SCIENCES: CURRENT APPLICATIONS TO FUTURE PERSPECTIVES

Authors

  • A ALI School of Biochemistry and Biotechnology, University of the Punjab, Pakistan
  • A KAMRAN College of Earth and Environmental Sciences University of the Punjab, Pakistan

DOI:

https://doi.org/10.54112/bcsrj.v2024i1.811

Abstract

This mini-review provides a comprehensive overview of the current applications and future perspectives of nanobiotechnology in health sciences. Drawing upon recent advancements, the review explores the role of nanoparticles in drug delivery, diagnostic imaging, therapeutics, regenerative medicine, and point-of-care diagnostics. Each application is discussed in detail, highlighting the significant contributions of nanotechnology to precision medicine, targeted therapy, bioimaging technologies, nanorobotics, and bioinformatics integration. Additionally, the review emphasizes the potential impact of nanobiotechnology on improving patient outcomes and advancing healthcare delivery. The review incorporates data from various databases, including PubMed, Web of Science, Scopus, and Google Scholar, to provide a comprehensive and up-to-date analysis of the field.

Downloads

Download data is not yet available.

References

Haleem A, Javaid M, Singh RP, Rab S, Suman R. Applications of nanotechnology in medical field: a brief review. Global Health Journal. 2023;7(2):70-7.

Malik S, Muhammad K, Waheed Y. Emerging applications of nanotechnology in healthcare and medicine. Molecules. 2023;28(18):6624.

Ahmad A, Khan F, Mishra RK, Khan R. Precision cancer nanotherapy: evolving role of multifunctional nanoparticles for cancer active targeting. Journal of medicinal chemistry. 2019;62(23):10475-96.

Das KP. Nanoparticles and convergence of artificial intelligence for targeted drug delivery for cancer therapy: Current progress and challenges. Frontiers in Medical Technology. 2023;4:1067144.

Ray S, Ray S, D'souza R, Srivastava S. Nanotechniques and Proteomics: An Integrated Platform for Diagnostics, Targeted Therapeutics and Personalized Medicine. Current Pharmacogenomics and Personalized Medicine (Formerly Current Pharmacogenomics). 2011;9(4):264-85.

Freitas SC, Sanderson D, Caspani S, Magalhães R, Cortés-Llanos B, Granja A, et al. New Frontiers in colorectal cancer treatment combining nanotechnology with photo-and radiotherapy. Cancers. 2023;15(2):383.

Rewatkar P, Kumeria T, Popat A. Size, shape and surface charge considerations of orally delivered nanomedicines. Nanotechnology for Oral Drug Delivery: Elsevier; 2020. p. 143-76.

de la Torre P, Pérez-Lorenzo MJ, Alcázar-Garrido Á, Flores AI. Cell-based nanoparticles delivery systems for targeted cancer therapy: lessons from anti-angiogenesis treatments. Molecules. 2020;25(3):715.

Luther DC, Huang R, Jeon T, Zhang X, Lee Y-W, Nagaraj H, et al. Delivery of drugs, proteins, and nucleic acids using inorganic nanoparticles. Advanced drug delivery reviews. 2020;156:188-213.

Sapsford KE, Algar WR, Berti L, Gemmill KB, Casey BJ, Oh E, et al. Functionalizing nanoparticles with biological molecules: developing chemistries that facilitate nanotechnology. Chemical reviews. 2013;113(3):1904-2074.

Date AA, Hanes J, Ensign LM. Nanoparticles for oral delivery: Design, evaluation and state-of-the-art. Journal of Controlled Release. 2016;240:504-26.

Rivas CJM, Tarhini M, Badri W, Miladi K, Greige-Gerges H, Nazari QA, et al. Nanoprecipitation process: From encapsulation to drug delivery. International journal of pharmaceutics. 2017;532(1):66-81.

Kairdolf BA, Qian X, Nie S. Bioconjugated nanoparticles for biosensing, in vivo imaging, and medical diagnostics. Analytical chemistry. 2017;89(2):1015-31.

Smith BA, Smith BD. Biomarkers and molecular probes for cell death imaging and targeted therapeutics. Bioconjugate chemistry. 2012;23(10):1989-2006.

Pellico J, Ellis CM, Davis JJ. Nanoparticle-based paramagnetic contrast agents for magnetic resonance imaging. Contrast media & molecular imaging. 2019;2019.

Han X, Xu K, Taratula O, Farsad K. Applications of nanoparticles in biomedical imaging. Nanoscale. 2019;11(3):799-819.

Hsu JC, Tang Z, Eremina OE, Sofias AM, Lammers T, Lovell JF, et al. Nanomaterial-based contrast agents. Nature Reviews Methods Primers. 2023;3(1):30.

Padmanabhan P, Kumar A, Kumar S, Chaudhary RK, Gulyás B. Nanoparticles in practice for molecular-imaging applications: an overview. Acta biomaterialia. 2016;41:1-16.

Ejigah V, Owoseni O, Bataille-Backer P, Ogundipe OD, Fisusi FA, Adesina SK. Approaches to improve macromolecule and nanoparticle accumulation in the tumor microenvironment by the enhanced permeability and retention effect. Polymers. 2022;14(13):2601.

Chowdhury A, Kunjiappan S, Panneerselvam T, Somasundaram B, Bhattacharjee C. Nanotechnology and nanocarrier-based approaches on treatment of degenerative diseases. International nano letters. 2017;7:91-122.

Yetisgin AA, Cetinel S, Zuvin M, Kosar A, Kutlu O. Therapeutic nanoparticles and their targeted delivery applications. Molecules. 2020;25(9):2193.

Attia MF, Anton N, Wallyn J, Omran Z, Vandamme TF. An overview of active and passive targeting strategies to improve the nanocarriers efficiency to tumour sites. Journal of Pharmacy and Pharmacology. 2019;71(8):1185-98.

Liu J, Li M, Luo Z, Dai L, Guo X, Cai K. Design of nanocarriers based on complex biological barriers in vivo for tumor therapy. Nano Today. 2017;15:56-90.

Fathi-Achachelouei M, Knopf-Marques H, Ribeiro da Silva CE, Barthès J, Bat E, Tezcaner A, et al. Use of nanoparticles in tissue engineering and regenerative medicine. Frontiers in bioengineering and biotechnology. 2019;7:113.

Ye G, Bao F, Zhang X, Song Z, Liao Y, Fei Y, et al. Nanomaterial-based scaffolds for bone tissue engineering and regeneration. Nanomedicine. 2020;15(20):1995-2017.

Holkar K, Behere I, Ingavle G. Constructing Three-Dimensional Microenvironments Using Engineered Biomaterials for Bone and Cartilage Tissue Regeneration. Functional Biomaterials: CRC Press; 2023. p. 213-36.

Zhang W, Yang Y, Cui B. New perspectives on the roles of nanoscale surface topography in modulating intracellular signaling. Current Opinion in Solid State and Materials Science. 2021;25(1):100873.

Julier Z, Park AJ, Briquez PS, Martino MM. Promoting tissue regeneration by modulating the immune system. Acta biomaterialia. 2017;53:13-28.

Rahman MM, Islam MR, Akash S, Harun-Or-Rashid M, Ray TK, Rahaman MS, et al. Recent advancements of nanoparticles application in cancer and neurodegenerative disorders: At a glance. Biomedicine & Pharmacotherapy. 2022;153:113305.

Syedmoradi L, Daneshpour M, Alvandipour M, Gomez FA, Hajghassem H, Omidfar K. Point of care testing: The impact of nanotechnology. Biosensors and Bioelectronics. 2017;87:373-87.

Jiang N, Tansukawat ND, Gonzalez-Macia L, Ates HC, Dincer C, Guder F, et al. Low-cost optical assays for point-of-care diagnosis in resource-limited settings. ACS sensors. 2021;6(6):2108-24.

Yang Y, Yang X, Yang Y, Yuan Q. Aptamer-functionalized carbon nanomaterials electrochemical sensors for detecting cancer relevant biomolecules. Carbon. 2018;129:380-95.

Jarockyte G, Karabanovas V, Rotomskis R, Mobasheri A. Multiplexed nanobiosensors: current trends in early diagnostics. Sensors. 2020;20(23):6890.

Castaneda C, Nalley K, Mannion C, Bhattacharyya P, Blake P, Pecora A, et al. Clinical decision support systems for improving diagnostic accuracy and achieving precision medicine. Journal of clinical bioinformatics. 2015;5:1-16.

Alghamdi MA, Fallica AN, Virzì N, Kesharwani P, Pittalà V, Greish K. The promise of nanotechnology in personalized medicine. Journal of personalized medicine. 2022;12(5):673.

Puri S, Mazza M, Roy G, England RM, Zhou L, Nourian S, et al. Evolution of nanomedicine formulations for targeted delivery and controlled release. Advanced Drug Delivery Reviews. 2023:114962.

Dhaliwal A, Zheng G. Improving accessibility of EPR-insensitive tumor phenotypes using EPR-adaptive strategies: Designing a new perspective in nanomedicine delivery. Theranostics. 2019;9(26):8091.

Hossen S, Hossain MK, Basher M, Mia M, Rahman M, Uddin MJ. Smart nanocarrier-based drug delivery systems for cancer therapy and toxicity studies: A review. Journal of advanced research. 2019;15:1-18.

Kamaly N, Xiao Z, Valencia PM, Radovic-Moreno AF, Farokhzad OC. Targeted polymeric therapeutic nanoparticles: design, development and clinical translation. Chemical Society Reviews. 2012;41(7):2971-3010.

Ehlerding EB, Grodzinski P, Cai W, Liu CH. Big potential from small agents: nanoparticles for imaging-based companion diagnostics. ACS nano. 2018;12(3):2106-21.

Singh R, Yadav V, Dhillon AK, Sharma A, Ahuja T, Siddhanta S. Emergence of Raman spectroscopy as a probing tool for theranostics. Nanotheranostics. 2023;7(3):216.

Wu Y, Ali MR, Chen K, Fang N, El-Sayed MA. Gold nanoparticles in biological optical imaging. Nano Today. 2019;24:120-40.

Tuguntaev RG, Hussain A, Fu C, Chen H, Tao Y, Huang Y, et al. Bioimaging guided pharmaceutical evaluations of nanomedicines for clinical translations. Journal of nanobiotechnology. 2022;20(1):236.

Ummat A, Sharma G, Mavroidis C, Dubey A. Bio-nanorobotics: state of the art and future challenges. Tissue Engineering and Artificial Organs. 2016:309-54.

Piantanida E, Alonci G, Bertucci A, De Cola L. Design of nanocomposite injectable hydrogels for minimally invasive surgery. Accounts of chemical research. 2019;52(8):2101-12.

Mohammad H, You HW, Umapathi M, Ravikumar KK, Mishra S. Strategies of Artificial intelligence tools in the domain of nanomedicine. Journal of Drug Delivery Science and Technology. 2023:105157.

Naeem A, Suhail M, Basit A, Yali L, Xia ZM, Qin Z, et al. Convergence of artificial intelligence and nanotechnology in the development of novel formulations for cancer treatment. A Handbook of Artificial Intelligence in Drug Delivery: Elsevier; 2023. p. 499-529.

Guo D, Ji X, Luo J. Rational nanocarrier design towards clinical translation of cancer nanotherapy. Biomedical Materials. 2021;16(3):032005.

Downloads

Published

2024-04-11

How to Cite

ALI , A., & KAMRAN , A. (2024). NANOBIOTECHNOLOGY IN HEALTH SCIENCES: CURRENT APPLICATIONS TO FUTURE PERSPECTIVES. Biological and Clinical Sciences Research Journal, 2024(1), 811. https://doi.org/10.54112/bcsrj.v2024i1.811

Most read articles by the same author(s)

1 2 3 > >>