VARIATIONS IN SERUM CONCENTRATIONS OF Hs-CRP IN PERIODONTITIS AND HEALTHY SUBJECTS

A AFZAAL; M AFZAAL; D TAHA; AW GHAURI; ZS KHAN; . QURATULAIN

doi:10.54112/bcsrj.v2024i1.713

Authors

A AFZAAL Department of Physiology, Baqai Medical University, Karachi, Pakistan
M AFZAAL Altamash Institute of Dental Medicine, Karachi, Pakistan
D TAHA Fatima Jinnah Dental College, Karachi, Pakistan
AW GHAURI Liaquat College of Medicine and Dentistry, Karachi, Pakistan
ZS KHAN Liaquat College of Medicine and Dentistry, Karachi, Pakistan
. QURATULAIN Baqai Medical University, Karachi, Pakistan

DOI:

https://doi.org/10.54112/bcsrj.v2024i1.713

Keywords:

CRP; Biomarkers; Inflammation; Periodontitis

Abstract

CRP is a plasma protein that measures the acute phase response to systemic inflammation and is one of the markers of choice in monitoring numerous chronic diseases. Patients with periodontitis have specific haematological variations, such as higher C-reactive protein (CRP) levels and elevated pro-inflammatory mediator levels. This study aims to quantify Hs-CRP levels in periodontally healthy and diseased subjects and evaluate the relationship between periodontitis and Hs-CRP levels. This Case-control study recruited 120 patients from two study groups—60 cases of chronic periodontitis (moderate to severe) and 60 controls. Periodontitis is assessed by three different index scores, namely: Community periodontal index score (CPI), Clinical attachment level (CAL) and periodontal probing depth (PPD). The Hs-CRP is measured due to its high sensitivity to assess systemic inflammation, making it more effective than conventional CRP tests. Our study results indicate that Hs-CRP levels increase subsequently with the severity of the periodontal disease. Moreover, Clinical attachment level (CAL) is the most significant indicator of Periodontitis that correlates with systemic inflammation in the body. Hence, concluding that periodontitis, being an oral condition, can have a massive impact on general systemic health, and elevated Hs-CRP levels, considered a biomarker of chronic systemic inflammation, can be a future risk to several fatal systemic diseases.

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