ASSOCIATION OF ALTERNATION IN INTESTINAL MICROBIOTA WITH IMPAIRED PSYCHOLOGICAL FUNCTION IN PATIENTS WITH INFLAMMATORY BOWEL DISEASES IN REMISSION

HA SHAHID; Z MALIK; M MALIK

doi:10.54112/bcsrj.v2023i1.386

Authors

HA SHAHID Department of Gastroenterology, THQ Hospital Haroonabad, Pakistan
Z MALIK Department of Medicine, Zafar Hospital Bhawalnagar, Pakistan
M MALIK Department of Medicine, DHQ Teaching Hospital Sahiwal, Pakistan

DOI:

https://doi.org/10.54112/bcsrj.v2023i1.386

Abstract

The prospective study was conducted in the Department of Gastroenterology, THQ Hospital, from April 2021 to April 2022 to evaluate the association between mucosa-associated psychological functioning and intestinal microbiota in IBD remission patients. The study was conducted on 200 patients with comparable numbers of UC and CD. At inclusion, clinical phenotyping of disease status, including disease activity, was done using modified Truelove and Witt’s activity index (MTWAI) and CD activity index (CDAI). Biopsies were used for DNA extraction. The microbial profile of UC and CD patients was evaluated in correlation to depression. Like anxiety, the highest taxonomic changes were noted in the Firmicutes phylum. Many negative correlations were noted between the abundance of various taxa in Firmicutes phylum and depression. An analysis was conducted to determine the relationship between anxiety, the abundance of certain microbial taxa, and the quality of life (QoL) of individuals with Crohn's disease (CD) and ulcerative colitis (UC). The results showed that there was a significant correlation between anxiety and a relative increase of taxa in CD only. Additionally, the QoL of those with CD had a negative correlation with the increase in taxa. For UC, the relationship was partly accurate. However, higher QoL was associated with the abundance of the RF32 family and Sutterella, indicating that these taxa could be potential markers of favorable outcomes.

Downloads

Download data is not yet available.

References

Antinozzi, M., Giffi, M., Sini, N., Gallè, F., Valeriani, F., De Vito, C., Liguori, G., Romano Spica, V., and Cattaruzza, M. S. (2022). Cigarette smoking and human gut microbiota in healthy adults: a systematic review. Biomedicines 10, 510.

de Araujo Goes, V., Tajudeen, Y. A., and El-Sherbini, M. S. (2022). The Correlations among Dietary Lifestyle, Microecology, and Mind-Altering Toxoplasmosis on the Health of People, Place, and the Planet. Challenges 13, 63.

Dong, L.-N., Wang, M., Guo, J., and Wang, J.-P. (2019). Role of intestinal microbiota and metabolites in inflammatory bowel disease. Chinese medical journal 132, 1610-1614.

Ferraris, C., Elli, M., and Tagliabue, A. (2020). Gut microbiota for health: how can diet maintain a healthy gut microbiota? , Vol. 12, pp. 3596. MDPI.

Gracie, D. J., Guthrie, E. A., Hamlin, P. J., and Ford, A. C. (2018). Bi-directionality of brain–gut interactions in patients with inflammatory bowel disease. Gastroenterology 154, 1635-1646. e3.

Khan, I., Ullah, N., Zha, L., Bai, Y., Khan, A., Zhao, T., Che, T., and Zhang, C. (2019). Alteration of gut microbiota in inflammatory bowel disease (IBD): cause or consequence? IBD treatment targeting the gut microbiome. Pathogens 8, 126.

Knowles, S. R., Graff, L. A., Wilding, H., Hewitt, C., Keefer, L., and Mikocka-Walus, A. (2018). Quality of life in inflammatory bowel disease: a systematic review and meta-analyses—part I. Inflammatory bowel diseases 24, 742-751.

Macpherson, A. J., Yilmaz, B., Limenitakis, J. P., and Ganal-Vonarburg, S. C. (2018). IgA function in relation to the intestinal microbiota. Annual review of immunology 36, 359-381.

Mei, H., Li, J., Liu, S., Jeyaraj, A., Zhuang, J., Wang, Y., Chen, X., Yuan, Q., and Li, X. (2023). The Role of Green Tea on the Regulation of Gut Microbes and Prevention of High-Fat Diet-Induced Metabolic Syndrome in Mice. Foods 12, 2953.

Miyoshi, J., and Chang, E. B. (2017). The gut microbiota and inflammatory bowel diseases. Translational Research 179, 38-48.

Narula, N., Alshahrani, A.-A., Yuan, Y., Reinisch, W., and Colombel, J.-F. (2019). Patient-reported outcomes and endoscopic appearance of ulcerative colitis: a systematic review and meta-analysis. Clinical Gastroenterology and Hepatology 17, 411-418. e3.

Spagnuolo, R., Basile, A., Corea, A., Iaquinta, F. S., Milić, N., Doldo, P., Luzza, F., and Abenavoli, L. (2022). Measuring Mood and Anxiety Disorders by Patient Reported Outcomes in Inflammatory Bowel Disease: A Literature Review Update. Reviews on Recent Clinical Trials 17, 156-170.

Tillisch, K., Labus, J., Kilpatrick, L., Jiang, Z., Stains, J., Ebrat, B., Guyonnet, D., Legrain–Raspaud, S., Trotin, B., and Naliboff, B. (2013). Consumption of fermented milk product with probiotic modulates brain activity. Gastroenterology 144, 1394-1401. e4.

Yilmaz, B., Juillerat, P., Øyås, O., Ramon, C., Bravo, F. D., Franc, Y., Fournier, N., Michetti, P., Mueller, C., and Geuking, M. (2019). Microbial network disturbances in relapsing refractory Crohn’s disease. Nature medicine 25, 323-336.

Zhou, Y., Chen, Y., He, H., Peng, M., Zeng, M., and Sun, H. (2023). The role of the indoles in microbiota-gut-brain axis and potential therapeutic targets: A focus on human neurological and neuropsychiatric diseases. Neuropharmacology, 109690.