• GZK NIAZI Department of Cardiology, Rawalpindi Institute of Cardiology, Rawalpindi, Pakistan
  • SN BUKHARI Department of Cardiology, Ch. Pervaiz Elahi Institute of Cardiology (CPEIC) Multan, Pakistan
  • F ADNAN Department of Cardiology, Ch. Pervaiz Elahi Institute of Cardiology (CPEIC) Multan, Pakistan
  • MF SHABBIR Department of Cardiology, Ch. Pervaiz Elahi Institute of Cardiology (CPEIC) Multan, Pakistan



Thrombolysis in myocardial infarction risk score, Gensini score, non-ST-elevation myocardial infarction


This study aimed to evaluate the relationship between TIMI risk score and the extent of coronary artery disease in non-STEMI patients. A descriptive prospective study was conducted in the Department of Cardiology of Chaudhary Pervez Elahi Institute of Cardiology, Multan, from 3rd June 2021-3rd June 2022. 237 patients admitted with NSTEMI within 7 days of admission were included. Baseline demographic characteristics were noted in a performed performance. The TIMI score for all patients was calculated. All patients underwent coronary angiography and the Gensini score was calculated. Average patients’ age was 54.44±9.10 years. The mean genuine score was 37.17±5.62, and the TIMI score was 3.93±1.42. There were 162 (68.35%) male and 75 (31.65%) female patients. Diabetes was found in 83 (35.02%) and hypertension in 124 (52.32%) patients. Family history of CAD was found in 54 (22.78%) patients, and hypercholesterolemia in 57 (22.05%) patients. TIMI score significantly correlated with Gensini score with a correlation coefficient (r) of 0.50 and p-value <0.0001. It is concluded that in NSTEMI patients, clinical risk stratification as determined by TIMI risk score is associated with the determined extent of the disease via the Gensini score.


Download data is not yet available.


Anderson, J. L., Adams, C. D., Antman, E. M., Bridges, C. R., Califf, R. M., Casey, D. E., Chavey, W. E., Fesmire, F. M., Hochman, J. S., and Levin, T. N. (2007). ACC/AHA 2007 guidelines for the management of patients with unstable angina/non–ST-elevation myocardial infarction: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Writing Committee to Revise the 2002 Guidelines for the Management of Patients With Unstable Angina/Non–ST-Elevation Myocardial Infarction) developed in collaboration with the American College of Emergency Physicians, the Society for Cardiovascular Angiography and Interventions, and the Society of Thoracic Surgeons endorsed by the American Association of Cardiovascular and Pulmonary Rehabilitation and the Society for Academic Emergency Medicine. Journal of the American College of Cardiology 50, e1-e157.

Barbosa, C. E., Viana, M., Brito, M., Sabino, M., Garcia, G., Maraux, M., Souza, A. C., Noya-Rabelo, M., Esteves, J. P., and Correia, L. C. L. (2012). Accuracy of the GRACE and TIMI scores in predicting the angiographic severity of acute coronary syndrome. Arquivos Brasileiros de Cardiologia 99, 818-824.

Butt, U. M., Ali, M., Ayub, M. E., and Qureshi, M. A. (2018). Correlation of TIMI risk score with severity of coronary artery disease by coronary angiogram in patients with non-ST–elevation myocardial infarction. Pakistan Heart Journal 51.

Calvin, J. E., Klein, L. W., VandenBerg, B. J., Meyer, P., Condon, J. V., Snell, R. J., Ramirez-Morgen, L. M., and Parrillo, J. E. (1995). Risk stratification in unstable angina: prospective validation of the Braunwald classification. Jama 273, 136-141.

Farhi, J.-I. (1986). The broad spectrum of unstable angina pectoris and its implication for future controlled trials. Am J Cardiol 58, 547-550.

Health, T. L. G. (2018). Getting to the heart of non-communicable diseases. Vol. 6, pp. e933.

Hsia, R. Y., Hale, Z., and Tabas, J. A. (2016). A national study of the prevalence of life-threatening diagnoses in patients with chest pain. JAMA internal medicine 176, 1029-1032.

Lakhani, M. S., Qadir, F., Hanif, B., Farooq, S., and Khan, M. (2010). Correlation of thrombolysis in myocardial infarction (TIMI) risk score with extent of coronary artery disease in patients with acute coronary syndrome. Age (years) 56, 64.43-10.9.

Lindholm, D., Alfredsson, J., Angerås, O., Böhm, F., Calais, F., Koul, S., Lagerqvist, B., Renlund, H., Sarno, G., and Varenhorst, C. (2017). Timing of percutaneous coronary intervention in patients with non-ST-elevation myocardial infarction: a SWEDEHEART study. European Heart Journal-Quality of Care and Clinical Outcomes 3, 53-60.

Mok, Y., Ballew, S. H., Bash, L. D., Bhatt, D. L., Boden, W. E., Bonaca, M. P., Carrero, J. J., Coresh, J., D'Agostino Sr, R. B., and Elley, C. R. (2018). International validation of the thrombolysis in myocardial infarction (TIMI) risk score for secondary prevention in post‐MI patients: a collaborative analysis of the chronic kidney disease prognosis consortium and the risk validation scientific committee. Journal of the American Heart Association 7, e008426.

Numasawa, Y., Kohsaka, S., Miyata, H., Kawamura, A., Noma, S., Suzuki, M., Nakagawa, S., Momiyama, Y., Takahashi, T., and Sato, Y. (2013). Use of Thrombolysis in Myocardial Infarction Risk Score to predict bleeding complications in patients with unstable angina and non-ST elevation myocardial infarction undergoing percutaneous coronary intervention. Cardiovascular intervention and therapeutics 28, 242-249.

Organization, W. H. (2009). Cardiovascular diseases (cvds). http://www. who. int/mediacentre/factsheets/fs317/en/index. html.

Santos, E. S. d., Aguiar Filho, L. d. F., Fonseca, D. M., Londero, H. J., Xavier, R. M., Pereira, M. P., Minuzzo, L., Souza, R. d., and Timerman, A. (2013). Correlation of risk scores with coronary anatomy in non-ST-elevation acute coronary syndrome. Arquivos Brasileiros de Cardiologia 100, 511-517.

Sattar, S., Ahmed, N., Akhter, Z., Aijaz, S., Lakhani, S., Malik, R., and Pathan, A. (2019). In-Hospital outcomes in acute coronary syndrome patients with concomitant severe chronic kidney disease undergoing percutaneous coronary intervention. Pakistan Journal of Medical Sciences 35, 291.

Shaikh, M. K., Hanif, B., Shaikh, K., Khan, W., and Parkash, J. (2014). Validation of Grace Risk Score in predicting in-hospital mortality in patients with non ST-elevation myocardial infarction and unstable angina. JPMA 64, 807-11.

Terkelsen, C. J., Lassen, J. F., Nørgaard, B. L., Gerdes, J. C., Jensen, T., Gøtzsche, L. B.-H., Nielsen, T. T., and Andersen, H. R. (2005). Mortality rates in patients with ST-elevation vs. non-ST-elevation acute myocardial infarction: observations from an unselected cohort. European heart journal 26, 18-26.

Zhou, B.-Y., Guo, Y.-L., Wu, N.-Q., Zhu, C.-G., Gao, Y., Qing, P., Li, X.-L., Wang, Y., Liu, G., and Dong, Q. (2016). Free triiodothyronine in relation to coronary severity at different ages: Gensini score assessment in 4206 euthyroid patients. Journal of Geriatric Cardiology: JGC 13, 978.




How to Cite

NIAZI, G., BUKHARI, S., ADNAN, F., & SHABBIR, M. (2023). ASSOCIATION BETWEEN TIMI RISK SCORE AND SEVERITY OF CAD IN NON-STEMI CASES. Biological and Clinical Sciences Research Journal, 2023(1), 220.