Frequency of Preterm Birth in Multiple Gestations Presenting at Mardan Medical Complex

Authors

  • Shafaq Shehzadi Department of Obstetrics & Gynaecology, Mardan Medical Complex, MTI Mardan, Pakistan
  • Nuzhat Amin Department of Obstetrics & Gynaecology, Mardan Medical Complex, MTI Mardan, Pakistan

DOI:

https://doi.org/10.54112/bcsrj.v6i5.2106

Keywords:

Preterm Birth, Multiple Gestation, Maternal Education, Risk Factors

Abstract

Multiple gestations are associated with increased maternal and neonatal risks, with preterm birth being one of the most significant contributors to perinatal morbidity and mortality. Identifying the frequency and associated factors of preterm birth in multiple pregnancies is essential for improving obstetric outcomes, particularly in resource-limited settings. Objective: To determine the frequency of preterm birth in women with various gestations presenting at Mardan Medical Complex, Mardan. Methods: This cross-sectional study was conducted in the Department of Obstetrics and Gynaecology, Mardan Medical Complex, Mardan, from August 15, 2024, to February 15, 2025. A total of 78 women with multiple gestations, defined as the simultaneous development of more than one fetus in the uterus, were included. Preterm birth was defined as delivery before 37 completed weeks of gestation. Data were analyzed using SPSS version 27, and preterm birth was reported as frequencies and percentages. Associations between variables were assessed, with a p-value <0.05 considered statistically significant. Results: The mean maternal age was 28.67 ± 6.94 years. Preterm birth occurred in 32 women (41.0%). Caesarean section was the predominant mode of delivery, accounting for 56 cases (71.8%). A statistically significant association was observed between maternal education and preterm birth, with 27 (84.4%) of women who delivered preterm being uneducated (p < 0.001). Conclusion: The frequency of preterm birth in multiple gestations was high in the present study. Lack of maternal education was significantly associated with an increased risk of preterm delivery. Targeted antenatal care and educational interventions may help reduce preterm birth rates in women with multiple pregnancies.

Downloads

Download data is not yet available.

References

Duffy CR. Multifetal gestations and associated perinatal risks. NeoReviews. 2021;22(11):734–746. https://doi.org/10.1542/neo.22-11-e734

Swanson K, Debbink M, Letourneau JM, Kuppermann M, Einerson BD. Association of multifetal gestation with obstetric and neonatal outcomes in gestational carrier pregnancies. J Assist Reprod Genet. 2021;38(3):661–667. https://doi.org/10.1007/s10815-020-02034-8

American College of Obstetricians and Gynecologists. Multifetal gestations: twin, triplet, and higher-order multifetal pregnancies. ACOG Practice Bulletin No. 231. Obstet Gynecol. 2021;137(6):145–162. https://doi.org/10.1097/AOG.0000000000004397

Aviram A, Lipworth H, Asztalos EV, Mei-Dan E, Melamed N, Cao X, et al. Delivery of monochorionic twins: lessons learned from the Twin Birth Study. Am J Obstet Gynecol. 2020;223(6):916.e1–916.e9. https://doi.org/10.1016/j.ajog.2020.06.048

Zeng C, Liu X, Zhao Y, Pei C, Fu Y, Wang W, et al. Pregnancy outcomes and factors affecting the clinical effects of emergency cerclage in twin pregnancies with cervical dilation and prolapsed membranes. Int J Gynaecol Obstet. 2022;157(2):313–321. https://doi.org/10.1002/ijgo.13774

Seetho S, Kongwattanakul K, Saksiriwuttho P, Thepsuthammarat K. Epidemiology and factors associated with preterm births in multiple pregnancy: a retrospective cohort study. BMC Pregnancy Childbirth. 2023;23(1):872. https://doi.org/10.1186/s12884-023-06186-0

Li S, Gao J, Liu J, Hu J, Chen X, He J, et al. Perinatal outcomes and risk factors for preterm birth in twin pregnancies in a Chinese population: a multicenter retrospective study. Front Med. 2021;8:657862. https://doi.org/10.3389/fmed.2021.657862

Oger AS, Robillard PY, Barau G, Randrianaivo H, Bonsante F, Iacobelli S, et al. Perinatal outcome of monochorionic and dichorionic twin gestations: a study of 775 pregnancies at Reunion Island. J Gynecol Obstet Biol Reprod. 2013;42(7):655–661. https://doi.org/10.1016/j.jgyn.2013.02.010

McLeod JS, Menon A, Matusko N, Weiner GM, Gadepalli SK, Barks J, et al. Comparing mortality risk models in very low birth weight and preterm infants: a systematic review and meta-analysis. J Perinatol. 2020;40(5):695–703.

Bell EF, Hintz SR, Hansen NI, Bann CM, Wyckoff MH, DeMauro SB, et al. Mortality, in-hospital morbidity, care practices, and two-year outcomes for extremely preterm infants in the United States, 2013–2018. JAMA. 2022;327(3):248–263. https://doi.org/10.1001/jama.2021.23580

Ji X, Wu C, Chen M, Wu L, Li T, Miao Z, et al. Analysis of risk factors related to extremely and very preterm birth: a retrospective study. BMC Pregnancy Childbirth. 2022;22(1):818. https://doi.org/10.1186/s12884-022-05119-7

Chang YK, Tseng YT, Chen KT. Epidemiologic characteristics and associated risk factors of preterm birth in Taiwan from 2004 to 2013. BMC Pregnancy Childbirth. 2020;20(1):201. https://doi.org/10.1186/s12884-020-02903-1

Iftikhar A, Asghar A, Jehangir AM. Frequency of preterm births among pregnant women with twin pregnancy at a tertiary care hospital. J Med Physiol Biol. 2019;62(7):46–49. https://doi.org/10.7176/JMPB/62-11

Kurdi AM, Mesleh RA, Al-Hakeem MM, Khashoggi TY, Khalifa HM. Multiple pregnancy and preterm labor. Saudi Med J. 2004;25(5):632–637.

Du L, Du X, Wang W, Hu L, Qiao C, Shi R. Clinical analysis on the influencing factors related to preterm twin pregnancy. Rev Assoc Med Bras. 2022;68(12):1651–1656. https://doi.org/10.1590/1806-9282.20220447

Gashi AM. The contribution of multiple pregnancies increases the rate of cesarean birth. Medicine. 2015;3(6):230–233.

Brancazio SN, Frankel LR, Quinn KH, Denney JM. Evidence-based management of multiple gestation. Arch Obstet Gynecol. 2024;5(3):107–123. https://doi.org/10.33696/Gynaecology.5.069

Sumaira, Qayyum S, Adil A, Sarwar S, Bibi N, Khan SJ. Clinical and demographic factors associated with preterm labor in twin pregnancies at Mardan Medical Complex. Pak J Health Sci. 2024;5(11):74–78. https://doi.org/10.54393/pjhs.v5i11.2139

Zhang X, Yin B, Wu K, Fang L, Chen Y. Association between maternal gestational weight gain and preterm birth according to pre-pregnancy body mass index and HbA1c. J Obstet Gynaecol. 2024;44(1):2359671. https://doi.org/10.1080/01443615.2024.2359671

Al-Obaidly S, Al-Ibrahim A, Khaldi HM, Bayo A. The impact of a previous caesarean section on obstetric decision in twin gestation. Eur J Obstet Gynecol Reprod Biol. 2016;206:e5–e6.

Fuchs F, Senat MV. Multiple gestations and preterm birth. Semin Fetal Neonatal Med. 2016;21(2):113–120. https://doi.org/10.1016/j.siny.2015.12.010

Downloads

Published

2025-05-31

How to Cite

Shehzadi, S. ., & Amin, N. . (2025). Frequency of Preterm Birth in Multiple Gestations Presenting at Mardan Medical Complex. Biological and Clinical Sciences Research Journal, 6(5), 350–352. https://doi.org/10.54112/bcsrj.v6i5.2106

Issue

Section

Original Research Articles