FREQUENCY OF TORCH INFECTION AMONG CONGENITAL CATARACT PATIENTS

Authors

  • SA BHUTTO Department of Ophthalmology, Chandka Medical College & Hospital Shaheed Mohtarma Benazir Bhutto Medical University Larkana Pakistan
  • AA ABRO Department of Ophthalmology, Chandka Medical College & Hospital Shaheed Mohtarma Benazir Bhutto Medical University Larkana Pakistan
  • NA KATPAR Department of Ophthalmology, Chandka Medical College & Hospital Shaheed Mohtarma Benazir Bhutto Medical University Larkana Pakistan
  • DD SHAIKH Department of Ophthalmology, Chandka Medical College & Hospital Shaheed Mohtarma Benazir Bhutto Medical University Larkana Pakistan
  • SA ABBASI Department of Ophthalmology, Chandka Medical College & Hospital Shaheed Mohtarma Benazir Bhutto Medical University Larkana Pakistan
  • PA GUL Department of Ophthalmology, Layton Rahmatulla Benevolent Trust (LRBT) Gambat Sindh, Pakistan

DOI:

https://doi.org/10.54112/bcsrj.v2024i1.758

Keywords:

TORCH, Congenital Cataract, Children

Abstract

The objective of this descriptive cross-sectional study was to determine the frequency of TORCH infections among congenital cataract patients. The study was conducted at Shaheed Mohtarma Benazir Bhutto Medical University Larkana, from September 22, 2021, to March 21, 2022. Patients meeting the inclusion criteria, including those diagnosed with congenital cataracts and TORCH infection within the age range of one day to ten years, were included after obtaining informed consent from their guardians. A slit lamp examination was performed to identify lens opacities indicative of congenital cataracts. Subsequently, patients with congenital cataracts were sent for laboratory investigation. TORCH infections were diagnosed based on IgM levels and clinical manifestations specific to each pathogen. The results revealed that the age range of the patients included in the study was one day to ten years, with a mean age of 17.9 ± 21.8 months. Of the 85 patients with congenital cataracts, 36 (42.5%) were male, and 49 (57.5%) were female. Interestingly, TORCH infection was identified in 17 (19.6%) patients with congenital cataracts, while the remaining patients showed no evidence of TORCH infection. In conclusion, TORCH pathogens, particularly cytomegalovirus and rubella virus, were found to be frequent causative agents of congenital cataracts. These findings highlight the importance of early diagnosis and management of TORCH infections in patients with congenital cataracts to prevent visual impairment and other associated complications.

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References

Abrahamsson, M., Magnusson, G., Sjostrom, A., Popovic, Z., and Sjostrand, J. (1999). The occurrence of congenital cataract in western Sweden. Acta Ophthalmologica Scandinavica 77, 578-580.

Akter, S., Eguchi, M., Kochi, T., Kabe, I., Nanri, A., and Mizoue, T. (2020). Association of serum calcium and phosphate concentrations with glucose metabolism markers: the Furukawa nutrition and health study. Nutrients 12, 2344.

Baghel, S., and Inamdar, S. A. (2020). TORCH Infection and Its Influence on High-risk Pregnancy. Journal of South Asian Federation of Obstetrics and Gynaecology 12, 377.

Bhatti, T. R., Dott, M., Yoon, P. W., Moore, C. A., Gambrell, D., and Rasmussen, S. A. (2003). Descriptive epidemiology of infantile cataracts in metropolitan Atlanta, GA, 1968-1998. Archives of pediatrics & adolescent medicine 157, 341-347.

de Jong, E. P., Vossen, A. C., Walther, F. J., and Lopriore, E. (2013). How to use... neonatal TORCH testing. Archives of Disease in Childhood-Education and Practice 98, 93-98.

Dishika, K., and Kanchan, S. (2022). The Prevalence of Cataract in Children. Cureus 14.

Gordon‐Lipkin, E., Hoon, A., and Pardo, C. A. (2021). Prenatal cytomegalovirus, rubella, and Zika virus infections associated with developmental disabilities: past, present, and future. Developmental Medicine & Child Neurology 63, 135-143.

Hammad, W. A. B., and Konje, J. C. (2021). Herpes simplex virus infection in pregnancy–An update. European Journal of Obstetrics & Gynecology and Reproductive Biology 259, 38-45.

Holmes, J. M., Leske, D. A., Burke, J. P., and Hodge, D. O. (2003). Birth prevalence of visually significant infantile cataract in a defined US population. Ophthalmic epidemiology 10, 67-74.

Katre, D., and Selukar, K. (2022). The prevalence of cataract in children. Cureus 14.

Lin, H., Long, E., Chen, W., and Liu, Y. (2015). Documenting rare disease data in China. Science 349, 1064-1064.

Lu, B., and Yang, Y. (2016). Detection of TORCH pathogens in children with congenital cataracts. Experimental and Therapeutic Medicine 12, 1159-1164.

MATOBA, A. (1984). Ocular viral infections. The Pediatric Infectious Disease Journal 3, 358-368.

Mawson, A. R., and Croft, A. M. (2019). Rubella virus infection, the congenital rubella syndrome, and the link to autism. International journal of environmental research and public health 16, 3543.

Megli, C. J., and Coyne, C. B. (2022). Infections at the maternal–fetal interface: an overview of pathogenesis and defence. Nature Reviews Microbiology 20, 67-82.

Morsy, T. A., Hussein, H. E., and MORSY, A. T. (2022). TORCH infections, pathogenicity & mortality assessments. Journal of the Egyptian Society of Parasitology 52, 53-70.

Naz, S., Sharif, S., Badar, H., Rashid, F., Kaleem, A., and Iqtedar, M. (2016). Incidence of environmental and genetic factors causing congenital cataract in Children of Lahore. J Pak Med Assoc 66, 819-22.

Neu, N., Duchon, J., and Zachariah, P. (2015). TORCH infections. Clinics in perinatology 42, 77-103.

Rahi, J. S., Dezateux, C., and Group, B. C. C. I. (2000). Congenital and infantile cataract in the United Kingdom: underlying or associated factors. Investigative ophthalmology & visual science 41, 2108-2114.

Rajavi, Z., Mokhtari, S., Sabbaghi, H., and Yaseri, M. (2015). Long-term visual outcome of congenital cataract at a Tertiary Referral Center from 2004 to 2014. Journal of Current Ophthalmology 27, 103-109.

Saleem, T., Dareshani, S., Quraishy, M. M., and Islam, F. (2015). Infectious aetiology of congenital cataract based on torch. J Liaquat Uni Med Health Sci 14, 48-51.

Sekeroglu, H., and Utine, G. E. (2021). Congenital cataract and its genetics: the era of next-generation sequencing. Turk. J. Ophthalmol 51, 107-113.

Singh, M. P., Ram, J., Kumar, A., Khurana, J., Marbaniang, M., and Ratho, R. K. (2016). Infectious agents in congenital cataract in a tertiary care referral center in North India. Diagnostic microbiology and infectious disease 85, 477-481.

Taruscio, D., Capozzoli, F., and Frank, C. (2011). Rare diseases and orphan drugs. Annali dell'Istituto superiore di sanità 47, 83-93.

Ting, X. W., Teh, W. M., Chan, C. S., Jalil, N. F. A., and Muhammed, J. (2020). Clinical Profile and Visual Outcome of Pediatric Cataract Surgeries in West Malaysia. Malaysian Journal of Paediatrics and Child Health 26, 27-34.

Wirth, M., Russell-Eggitt, I., Craig, J., Elder, J., and Mackey, D. (2002). Aetiology of congenital and paediatric cataract in an Australian population. British Journal of Ophthalmology 86, 782-786.

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Published

2024-03-22

How to Cite

BHUTTO , S., ABRO , A., KATPAR , N., SHAIKH , D., ABBASI , S., & GUL , P. (2024). FREQUENCY OF TORCH INFECTION AMONG CONGENITAL CATARACT PATIENTS. Biological and Clinical Sciences Research Journal, 2024(1), 758. https://doi.org/10.54112/bcsrj.v2024i1.758