A RETROSPECTIVE STUDY ON MATERNAL AND FETAL OUTCOMES ASSOCIATED WITH ASSISTED REPRODUCTIVE TECHNOLOGIES

W HAQ; F AWAN; S TAJ; DR ARSH; R BHITTANI

doi:10.54112/bcsrj.v2024i1.712

Authors

W HAQ MMC Peshawar, Pakistan
F AWAN Lady Reading Hospital Peshawar, Pakistan
S TAJ Civil Dispensary Chamtar, Mardan, Pakistan
DR ARSH BHU Kababian, Malteser International, Peshawar, Pakistan
R BHITTANI Shifa International Hospital,Islamabad, Pakistan

DOI:

https://doi.org/10.54112/bcsrj.v2024i1.712

Keywords:

Assisted Reproductive Technologies (ART), Maternal Outcomes, In Vitro Fertilization (IVF), Intracytoplasmic Sperm Injection (ICSI), Pregnancy-Related Hypertensive Disorders, Gestational Diabetes

Abstract

Assisted Reproductive Technologies (ART) have revolutionized the landscape of reproductive medicine, offering hope to couples facing infertility challenges. The study's main objective is to find the maternal and fetal outcomes associated with assisted reproductive technologies. This retrospective cohort study was conducted in Lady Reading Hospital Peshawar from July 2019 to June 2023. The study includes 850 participants who underwent ART procedures between 2021 and 2022. Details of the ART procedures, such as the technique employed, the number of embryos transferred, and the utilization of preimplantation genetic testing, were meticulously documented. Maternal outcomes were a focal point, with a comprehensive assessment of pregnancy-related hypertensive disorders, gestational diabetes, mode of delivery, and any postpartum complications. Data was collected from 850 participants. The mean maternal age was 33.5 years (SD = 4.2), and the mean BMI was 25.8 (SD = 3.5). The primary causes of infertility varied, with male factor infertility being the most prevalent at 40%, followed by ovulatory dysfunction at 30% and unexplained infertility at 20%. The ART procedures in the study cohort comprised In Vitro Fertilization (IVF) at 60%, followed by Intracytoplasmic Sperm Injection (ICSI) at 25%, and other ART techniques at 15%. Regarding the number of embryos transferred, the majority received a single source (70%), with 20% receiving two starts and 10% receiving three or more. It is concluded that pregnancies conceived through Assisted Reproductive Technologies (ART) exhibit a higher prevalence of pregnancy-related hypertensive disorders and gestational diabetes compared to naturally conceived pregnancies.

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References

Abdulrazaq, A. A., Ainsworth, A. J., Britton, J. W., Shenoy, C. C., Babayev, S. N., Cascino, G. D., and Smith, K. M. (2023). Seizure control in women with epilepsy undergoing assisted reproductive technology. Epilepsia 64, e207-e213.

Abu Nofal, M., Abd Elgani, S., Zafran, N., Garmi, G., Romano, S., and Salim, R. (2023). Neonatal condition at birth of twins conceived by medically assisted reproductive technology compared to those conceived spontaneously: A retrospective study. International Journal of Gynecology & Obstetrics.

Brekke, P. H., Rama, T., Pilán, I., Nytrø, Ø., and Øvrelid, L. (2021). Synthetic data for annotation and extraction of family history information from clinical text. Journal of Biomedical Semantics 12, 1-11.

Çelik, S., and Çalışkan, C. (2021). The impact of assisted reproductive Technology in Twin Pregnancies Complicated by intrahepatic Cholestasis of pregnancy: a retrospective cohort study. Zeitschrift für Geburtshilfe und Neonatologie 225, 34-38.

da Silva, S. G., da Silveira, M. F., Bertoldi, A. D., Domingues, M. R., and Dos Santos, I. d. S. (2020). Maternal and child-health outcomes in pregnancies following Assisted Reproductive Technology (ART): a prospective cohort study. BMC Pregnancy and Childbirth 20, 1-8.

He, M., Sun, X., Wang, C., and Sui, Y. (2022). Analysis of the risk of complications during pregnancy in pregnant women with assisted reproductive technology: a retrospective study using registry linkage from 2013 to 2018 in Shanghai, China. BMC Pregnancy and Childbirth 22, 1-11.

Lao, M., Dai, P., Luo, G., Yang, X., Peng, M., Chen, Y., Zhan, Y., Zhan, Z., and Chen, D. (2023). Pregnancy outcomes in patients receiving assisted reproductive therapy with systemic lupus erythematosus: a multi-center retrospective study. Arthritis research & therapy 25, 1-10.

Magnusson, Å., Laivuori, H., Loft, A., Oldereid, N. B., Pinborg, A., Petzold, M., Romundstad, L. B., Söderström-Anttila, V., and Bergh, C. (2021). The association between high birth weight and long-term outcomes—implications for assisted reproductive technologies: a systematic review and meta-analysis. Frontiers in pediatrics 9, 675775.

Maignien, C., Bourdon, M., Ferreux, L., Parpex, G., and Santulli, P. (2023). ENDOMETRIOSIS: SEVERE PAIN SYMPTOMS DO NOT IMPACT ART (ASSISTED REPRODUCTIVE TECHNOLOGY) OUTCOMES. Fertility and Sterility 120, e295.

Qu, P., Mi, Y., Zhao, D., Wang, M., Dang, S., Shi, W., and Shi, J. (2020). Effect of the interaction between pre-pregnancy body mass index and fresh/frozen embryo transfer on perinatal outcomes of assisted reproductive technology-conceived singletons: a retrospective cohort study. Frontiers in Endocrinology 11, 560103.

Sabr, Y., Lisonkova, S., Skoll, A., Brant, R., Velez, M. P., and Joseph, K. (2022). Severe maternal morbidity and maternal mortality associated with assisted reproductive technology. Journal of Obstetrics and Gynaecology Canada 44, 978-986.

Stephenson, A. L., Sykes, J., Stanojevic, S., Quon, B. S., Marshall, B. C., Petren, K., Ostrenga, J., Fink, A. K., Elbert, A., and Goss, C. H. (2017). Survival comparison of patients with cystic fibrosis in Canada and the United States: a population-based cohort study. Annals of internal medicine 166, 537-546.

Tai, W., Hu, L., and Wen, J. (2022). Maternal and neonatal outcomes after assisted reproductive technology: a retrospective cohort study in China. Frontiers in Medicine 9, 837762.

Tanaka, H., Tanaka, K., Osato, K., Kusaka, H., Maegawa, Y., Taniguchi, H., and Ikeda, T. (2020). Evaluation of maternal and neonatal outcomes of assisted reproduction technology: A retrospective cohort study. Medicina 56, 32.

Vermey, B., Buchanan, A., Chambers, G., Kolibianakis, E., Bosdou, J., Chapman, M., and Venetis, C. (2019). Are singleton pregnancies after assisted reproduction technology (ART) associated with a higher risk of placental anomalies compared with non‐ART singleton pregnancies? A systematic review and meta‐analysis. BJOG: An International Journal of Obstetrics & Gynaecology 126, 209-218.

Wei, C., Xiang, S., Liu, D., Wang, C., Liang, X., Wu, H., and Lian, F. (2023). Laser-assisted hatching improves pregnancy outcomes in frozen-thawed embryo transfer cycles of cleavage-stage embryos: a large retrospective cohort study with propensity score matching. Journal of Assisted Reproduction and Genetics 40, 417-427.

Woo, I., Hindoyan, R., Landay, M., Ho, J., Ingles, S. A., McGinnis, L. K., Paulson, R. J., and Chung, K. (2017). Perinatal outcomes after natural conception versus in vitro fertilization (IVF) in gestational surrogates: a model to evaluate IVF treatment versus maternal effects. Fertility and sterility 108, 993-998.

Wu, P., Sharma, G. V., Mehta, L. S., Chew‐Graham, C. A., Lundberg, G. P., Nerenberg, K. A., Graham, M. M., Chappell, L. C., Kadam, U. T., and Jordan, K. P. (2022). In‐hospital complications in pregnancies conceived by assisted reproductive technology. Journal of the American Heart Association 11, e022658.

Zheng, Z., Tan, J., Chen, L., Liu, S., Zhou, C., and Li, Y. (2023). PGT-A improved singleton live birth rate among all age groups of women who underwent elective single blastocyst transfer: a single-centre retrospective study. Journal of Assisted Reproduction and Genetics, 1-11.