RED BLOOD CELL INDICES IN PATIENTS WITH CARDIOVASCULAR DISEASES AT A TERTIARY CARE HOSPITAL PESHAWAR

A KHAN; F GOHAR; J AHMAD; L HUMAYUN; A KHAN; AK REHMAN

doi:10.54112/bcsrj.v2024i1.676

Authors

A KHAN Afridi Medical Complex and Teaching Hospital, Peshawar, Pakistan
F GOHAR Department of Microbiology, Faculty of Life Sciences, University of Central Punjab, Lahore, Pakistan
J AHMAD Faculty of Allied Health Science, University of Lahore, Pakistan
L HUMAYUN Department of Pathology, University College of Medicine and Dentistry University of Lahore, Pakistan
A KHAN Afridi Medical Complex and Teaching Hospital, Peshawar, Pakistan
AK REHMAN Department of Haematology, Kabir Medical College/MMC-General Hospital Peshawar, Pakistan

DOI:

https://doi.org/10.54112/bcsrj.v2024i1.676

Keywords:

Red Blood Cell Indices; Cardiovascular Diseases; Hemoglobin, Red Cell Distribution

Abstract

Cardiovascular diseases are a major cause of health loss worldwide, regardless of a country's income, social status, or demographics. Many studies have reported a link between haematological parameters and cardiovascular diseases in patients. This study aimed to determine the red blood cell indices in patients with cardiovascular diseases at a tertiary care hospital in Peshawar. The study was conducted for six months, from January 1, 2023, to June 30, 2023, at the Pathology Department of Afridi Medical Complex and Teaching Hospital. Blood samples were taken from patients in EDTA vacutainers, and their haematological parameters were determined in the laboratory. The patients' clinical examinations, history, name, gender, age, and previous laboratory investigations were recorded in a proforma designed for this research. The data were analyzed using IBM SPSS version 23. The study enrolled 80 patients with cardiovascular diseases, including 44 (55%) male and 36 (45%) female patients. The mean age of the study participants was 47 years, with a standard deviation of ±12.3. The mean (±SD) haemoglobin, red blood cell count, hematocrit, mean corpuscular haemoglobin, red cell distribution width-SD, and red cell distribution width-CV were 13.99 (±1.86) (g/dl), 4.49 (±0.55) (million/cm3), 40.72 (±5.81), 28.99 (±2.22), 62.06 (±6.99), and 16.87 (±3.39), respectively. The study concludes that red blood cell indices such as red cell distribution width, haemoglobin, and mean corpuscular volume play a significant role in the pathogenesis of cardiovascular diseases. Routine health examinations and proactive precautions may help lower cardiovascular disease incidence.

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References

Chonchol, M., & Nielson, C. (2008). Hemoglobin levels and coronary artery disease. American heart journal 155, 494-498.

Doganer, Y. C., Rohrer, J. E., Aydogan, U., Bernard, M. E., and Barcin, C. (2015). Haemoglobin levels correlates with the presence of coronary artery disease. Journal of evaluation in clinical practice 21, 937-942.

Fan, L., Gui, L., Chai, E. Q., and Wei, C. J. (2018). Routine hematological parameters are associated with short‐and long‐term prognosis of patients with ischemic stroke. Journal of clinical laboratory analysis 32, e22244.

Felker, G. M., Allen, L. A., Pocock, S. J., Shaw, L. K., McMurray, J. J., Pfeffer, M. A., Swedberg, K., Wang, D., Yusuf, S., and Michelson, E. L. (2007). Red cell distribution width as a novel prognostic marker in heart failure: data from the CHARM Program and the Duke Databank. Journal of the American College of Cardiology 50, 40-47.

Finch, C. A. (1972). Oxygen transport in man. Chest 61, 12S-13S.

Gersh, K. C., Nagaswami, C., and Weisel, J. W. (2009). Fibrin network structure and clot mechanical properties are altered by incorporation of erythrocytes. Thrombosis and haemostasis 102, 1169-1175.

Goldsmith, H. L., Bell, D. N., Braovac, S., Steinberg, A., and McIntosh, F. (1995). Physical and chemical effects of red cells in the shear-induced aggregation of human platelets. Biophysical journal 69, 1584-1595.

Gotoh, S., Hata, J., Ninomiya, T., Hirakawa, Y., Nagata, M., Mukai, N., Fukuhara, M., Ikeda, F., Ago, T., and Kitazono, T. (2015). Hematocrit and the risk of cardiovascular disease in a Japanese community: The Hisayama Study. Atherosclerosis 242, 199-204.

Khode, V., Sindhur, J., Kanabur, D., Ruikar, K., and Nallulwar, S. (2014). Association of red cell distribution width, haematocrit and other RBC indices with coronay artery disease: A case control study. Nigerian Journal of Cardiology 11, 88.

Li, L., Xie, W., Zheng, X.-L., Yin, W.-D., and Tang, C.-K. (2016). A novel peptide adropin in cardiovascular diseases. Clinica chimica acta 453, 107-113.

Mayer, G. A. (1965). Hematocrit and coronary heart disease. Canadian Medical Association Journal 93, 1151.

Montagnana, M., Cervellin, G., Meschi, T., and Lippi, G. (2012). The role of red blood cell distribution width in cardiovascular and thrombotic disorders. Clinical chemistry and laboratory medicine 50, 635-641.

Monteiro Júnior, J. G. d. M., Torres, D. d. O. C., da Silva, M. C. F. C., Ramos, T. M. d. B., Alves, M. L., Filho, W. J. N., Damasceno, E. P., Brunet, A. F., Bittencourt, M. S., and Pedrosa, R. P. (2015). Nucleated red blood cells as predictors of all-cause mortality in cardiac intensive care unit patients: a prospective cohort study. PLoS One 10, e0144259.

Sangoi, M. B., Rödel, A., Zorzo, P., Borges, P., Cargnin, L., De Carvalho, J., Premaor, M., and Moresco, R. (2014). Prognostic value of red blood cell distribution width in prediction of in-hospital mortality in patients with acute myocardial infarction. Clinical laboratory 60, 1351-1356.

Schmid-Schonbein, H., Wells, R., and Goldstone, J. (1969). Influence of deformability of human red cells upon blood viscosity. Circulation Research 25, 131-143.

Sprague, R. S., Ellsworth, M. L., Stephenson, A. H., and Lonigro, A. J. (1996). ATP: the red blood cell link to NO and local control of the pulmonary circulation. American Journal of Physiology-Heart and Circulatory Physiology 271, H2717-H2722.

Steptoe, A., Wikman, A., Molloy, G. J., and Kaski, J.-C. (2012). Anaemia and the development of depressive symptoms following acute coronary syndrome: longitudinal clinical observational study. BMJ open 2, e000551.

Thomas, H., Diamond, J., Vieco, A., Chaudhuri, S., Shinnar, E., Cromer, S., Perel, P., Mensah, G. A., Narula, J., and Johnson, C. O. (2018). Global atlas of cardiovascular disease. Glob Heart 13, 143-163.

Tonelli, M., Sacks, F., Arnold, M., Moye, L., Davis, B., and Pfeffer, M. (2008). Relation between red blood cell distribution width and cardiovascular event rate in people with coronary disease. Circulation 117, 163-168.

Toss, F., Nordström, A., and Nordström, P. (2013). Association between hematocrit in late adolescence and subsequent myocardial infarction in Swedish men. International journal of cardiology 168, 3588-3593.

Tülübaş, F., Gürel, A., Akkoyun, D. C., Akyüz, A., Alpsoy, Ş., Erdoğan, H., and Yilmaz, A. (2013). MCV and MCH values in coronary artery patients with positive Gensini score. European Journal of General Medicine 10, 131-135.

Verbrugge, S. E., and Huisman, A. (2015). Verification and standardization of blood cell counters for routine clinical laboratory tests. Clinics in laboratory medicine 35, 183-196.

Weiss, H. J., Lages, B., Hoffmann, T., and Turitto, V. T. (1996). Correction of the platelet adhesion defect in delta-storage pool deficiency at elevated hematocrit--possible role of adenosine diphosphate.

Whelihan, M. F., and Mann, K. G. (2013). The role of the red cell membrane in thrombin generation. Thrombosis research 131, 377-382.

Wohner, N. (2008). Role of cellular elements in thrombus formation and dissolution. Cardiovascular & Hematological Agents in Medicinal Chemistry (Formerly Current Medicinal Chemistry-Cardiovascular & Hematological Agents) 6, 224-228.