MATERNAL AND FETAL OUTCOME OF PREGNANT PATIENTS GIVEN COVID-19 VACCINATION DURING ANTENATAL PERIOD

SA SABIR; S SULTAN

doi:10.54112/bcsrj.v2024i1.653

Authors

SA SABIR Department of Obstetrics & Gynecology, Lady Reading Hospital, Pakistan
S SULTAN Department of Obstetrics & Gynecology, Lady Reading Hospital, Pakistan

DOI:

https://doi.org/10.54112/bcsrj.v2024i1.653

Keywords:

COVID-19, Vaccination, Pregnancy, Adverse outcomes

Abstract

This study aimed to assess potential adverse maternal and fetal outcomes among pregnant women who received COVID-19 vaccination during pregnancy. The study was conducted at the Lady Reading Hospital, Peshawar, gynaecology OPD. It included 120 pregnant females aged 18-35 years with a gestational age of more than 32 weeks. Of the 120 participants, 60 received the COVID-19 vaccine during pregnancy, while 60 did not. The study aimed to determine whether there were any adverse outcomes, such as eclampsia/preeclampsia, fetal growth restriction, NICU admission, preterm birth, birth weight, and postpartum haemorrhage. The study found that 60% of the participants were vaccinated for COVID-19 during pregnancy, while 60% did not receive the vaccine. Both cohorts showed no significant difference in terms of adverse outcomes such as eclampsia/preeclampsia, fetal growth restriction, NICU admission, preterm birth, birth weight, and postpartum haemorrhage. No significant difference was found in fetomaternal outcomes between the two groups. Pregnant females who received the COVID-19 vaccine during pregnancy did not experience any significant adverse outcomes such as eclampsia/preeclampsia, fetal growth restriction, NICU admission, preterm birth, birth weight, and postpartum haemorrhage.

Downloads

Download data is not yet available.

References

Bahl, P., Doolan, C., De Silva, C., Chughtai, A. A., Bourouiba, L., and MacIntyre, C. R. (2022). Airborne or droplet precautions for health workers treating coronavirus disease 2019? The Journal of infectious diseases 225, 1561-1568.

Baloch, S., Baloch, M. A., Zheng, T., and Pei, X. (2020). The coronavirus disease 2019 (COVID-19) pandemic. The Tohoku journal of experimental medicine 250, 271-278.

Blakeway, H., Prasad, S., Kalafat, E., Heath, P. T., Ladhani, S. N., Le Doare, K., Magee, L. A., O’brien, P., Rezvani, A., and von Dadelszen, P. (2022). COVID-19 vaccination during pregnancy: coverage and safety. American journal of obstetrics and gynecology 226, 236. e1-236. e14.

Bleicher, I., Kadour-Peero, E., Sagi-Dain, L., and Sagi, S. (2021). Early exploration of COVID-19 vaccination safety and effectiveness during pregnancy: interim descriptive data from a prospective observational study. Vaccine 39, 6535-6538.

Ellington, S., and Olson, C. K. (2022). Safety of mRNA COVID-19 vaccines during pregnancy. The Lancet Infectious Diseases 22, 1514-1515.

Fell, D. B., Dhinsa, T., Alton, G. D., Török, E., Dimanlig-Cruz, S., Regan, A. K., Sprague, A. E., Buchan, S. A., Kwong, J. C., and Wilson, S. E. (2022). Association of COVID-19 vaccination in pregnancy with adverse peripartum outcomes. Jama 327, 1478-1487.

Goldshtein, I., Nevo, D., Steinberg, D. M., Rotem, R. S., Gorfine, M., Chodick, G., and Segal, Y. (2021). Association between BNT162b2 vaccination and incidence of SARS-CoV-2 infection in pregnant women. Jama 326, 728-735.

Goncu Ayhan, S., Oluklu, D., Atalay, A., Menekse Beser, D., Tanacan, A., Moraloglu Tekin, O., and Sahin, D. (2021). COVID‐19 vaccine acceptance in pregnant women. International Journal of Gynecology & Obstetrics 154, 291-296.

Gray, K. J., Bordt, E. A., Atyeo, C., Deriso, E., Akinwunmi, B., Young, N., Baez, A. M., Shook, L. L., Cvrk, D., and James, K. (2021). Coronavirus disease 2019 vaccine response in pregnant and lactating women: a cohort study. American journal of obstetrics and gynecology 225, 303. e1-303. e17.

Joubert, E., Kekeh, A., and Amin, C. (2022). COVID‐19 and novel mRNA vaccines in pregnancy: an updated literature review. BJOG: An International Journal of Obstetrics & Gynaecology 129, 21-28.

Ma, Y., Deng, J., Liu, Q., Du, M., Liu, M., and Liu, J. (2022). Effectiveness and safety of COVID-19 vaccine among pregnant women in real-world studies: a systematic review and meta-analysis. Vaccines 10, 246.

Pukale, R. S., and Pragathi, D. (2021). Fetomaternal Outcome in Covid Positive Pregnant Women. Journal of Medical Sciences 7, 67.

Rasmussen, S. A., Kelley, C. F., Horton, J. P., and Jamieson, D. J. (2021). Coronavirus disease 2019 (COVID-19) vaccines and pregnancy: what obstetricians need to know. Obstetrics and gynecology 137, 408.

Regan, A. K., and Munoz, F. M. (2021). Efficacy and safety of influenza vaccination during pregnancy: realizing the potential of maternal influenza immunization. Expert Review of Vaccines 20, 649-660.

Riley, L. E. (2021). mRNA Covid-19 vaccines in pregnant women. Vol. 384, pp. 2342-2343. Mass Medical Soc.

Shah, P. T., Shah, S. R., Shah, S. R., Yadav, P. A., Patel, B. S., and Chudasama, T. J. (2020). Fetomaternal outcome in COVID-19 infected pregnant women: a preliminary clinical study. International Journal of Reproduction, Contraception, Obstetrics and Gynecology 9, 3704-3711.

Skjefte, M., Ngirbabul, M., Akeju, O., Escudero, D., Hernandez-Diaz, S., Wyszynski, D. F., and Wu, J. W. (2021). COVID-19 vaccine acceptance among pregnant women and mothers of young children: results of a survey in 16 countries. European journal of epidemiology 36, 197-211.

Süt, H., Yıldız, G. A., Şeker, E., Ümit, C., Koçar, M., and Koç, A. (2023). Maternal and perinatal outcomes of COVID-19 vaccination during pregnancy. Journal of the Turkish German Gynecological Association 24, 120.