FREQUENCY OF ACQUIRED DYSFIBRINOGENEMIA AMONG CHRONIC LIVER DISEASE PATIENTS PRESENTING AT TERTIARY CARE HOSPITAL

SU KHAN; MA SHAH; N SALAM; SK BALOCH; FN SYED; SAF RIZVI

doi:10.54112/bcsrj.v2023i1.415

Authors

SU KHAN District Health Office, Bannu, Health Department, Khyber PakhthonKhwa, Pakistan
MA SHAH Department of Pathology, Northwest School of Medicine Peshawar, KPK., Pakistan
N SALAM Department of Pathology, Avicenna Medical & Dental College Lahore, Punjab, Pakistan.
SK BALOCH Department of Pathology, Shahida Islam Medical College Lodhran, Pakistan
FN SYED Department of Pathology, CMH Multan Institute of Medical Sciences, Multan, Pakistan
SAF RIZVI Department of Anatomy, Ghulam Muhammad Mahar Medical College (GMMMC) Sukkur, Pakistan.

DOI:

https://doi.org/10.54112/bcsrj.v2023i1.415

Keywords:

Hepatitis C virus, Hepatitis B virus, Chronic Liver Disease, Acquired dysfibrinogenemia

Abstract

A cross-sectional study was conducted at the Department of Pathology, Sharif Medical and Dental College Lahore, Pakistan, from January 2023 to June 2023. The total no of patients was 120 presented with chronic liver disease. The frequency of acquired dysfibrinogenemia was determined. The Chi-Square test with a P value < 0.05 as significant was used for the association between categorical variables. Most of the patients presenting were male patients compared to female patients. The frequency of acquired dysfibrinogenemia was 45 (38.3%). We found a significant association between acquired dysfibrinogenemia and the severity of the disease on the Child-Pugh Score. Our study concluded that the frequency of acquired dysfibrinogenemia in chronic liver disease patients was 45 (38.3%).

Downloads

Download data is not yet available.

References

Acar, Ş., Güngör, G., Dayangaç, M., Diz-Küçükkaya, R., Tokat, Y., and Akyıldız, M. (2017). Liver transplantation in a patient with acquired dysfibrinogenemia who presented with subdural hematoma: A case report. Turkish Journal of Haematology 34, 356-357.

Arif, S., Khan, A. S., and Khan, A. R. (2002). Changes in fibrinogen level in liver cirrhosis. Journal of Ayub Medical College Abbottabad 14.

Casini, A., Undas, A., Palla, R., Thachil, J., and De Moerloose, P. (2018). Diagnosis and classification of congenital fibrinogen disorders: communication from the SSC of the ISTH. Journal of Thrombosis and Haemostasis 16, 1887-1890.

Cheemerla, S., and Balakrishnan, M. (2021). Global epidemiology of chronic liver disease. Clinical liver disease 17, 365.

Cunningham, M. T., Brandt, J. T., Laposata, M., and Olson, J. D. (2002). Laboratory diagnosis of dysfibrinogenemia. Archives of pathology & laboratory medicine 126, 499-505.

Francis, J., and Armstrong, D. (1982). Acquired dysfibrinogenaemia in liver disease. Journal of Clinical Pathology 35, 667-672.

Li, Y., Ding, B., Wang, X., and Ding, Q. (2022). Congenital (hypo-) dysfibrinogenemia and bleeding: A systematic literature review. Thrombosis Research.

Marik, P. E., and Liggett, A. (2019). Adding an orange to the banana bag: vitamin C deficiency is common in alcohol use disorders. Critical Care 23, 1-6.

Merli, M., Berzigotti, A., Zelber-Sagi, S., Dasarathy, S., Montagnese, S., Genton, L., Plauth, M., and Parés, A. (2019). EASL Clinical Practice Guidelines on nutrition in chronic liver disease. Journal of hepatology 70, 172-193.

Nagler, M., Hovinga, J. A. K., Alberio, L., Peter-Salonen, K., von Tengg-Kobligk, H., Lottaz, D., Neerman-Arbez, M., and Lämmle, B. (2016). Thromboembolism in patients with congenital afibrinogenaemia. Thrombosis and haemostasis 116, 722-732.

Noor, A., Shafiq, M., Ali, N., and Siddiq, A. (2018). Frequency of acquired dysfibrinogenemia in patients of chronic liver disease. Pakistan Journal of Pathology 29, 81-85.

Sepanlou, S. G., Safiri, S., Bisignano, C., Ikuta, K. S., Merat, S., Saberifiroozi, M., Poustchi, H., Tsoi, D., Colombara, D. V., and Abdoli, A. (2020). The global, regional, and national burden of cirrhosis by cause in 195 countries and territories, 1990–2017: a systematic analysis for the Global Burden of Disease Study 2017. The Lancet gastroenterology & hepatology 5, 245-266.

Shapiro, S. E. (2018). Diagnosis and management of dysfibrinogenemia. Clin Adv Hematol Oncol 16, 602-5.

Sirhindi, G. A., Sirhindi, Y. A., and Sirhindi, A. A. (2020). Determine the Prevalence of Acquired Dysfibrinogenemia in Patients Presented with Chronic Liver Disease. Age (years) 46, 15.47.

Yan, J., Luo, M., Xiang, L., Wu, Y., and Lin, F. (2022). Congenital dysfibrinogenemia in major surgery: A description of four cases and review of the literature. Clinica Chimica Acta 528, 1-5.