Prevalence of Hyperbilirubinemia in Preterm Neonates Admitted to the Nursery of Mufti Mehmood Hospital, Gomal Medical College, D.I. Khan
DOI:
https://doi.org/10.54112/bcsrj.v6i6.2190Keywords:
Hyperbilirubinemia; Infant, Premature; Jaundice, Neonatal; Phototherapy; PrevalenceAbstract
Pre-term neonates are known to be more susceptible to various forms of metabolic complications due to immature hepatic function. Hyperbilirubinemia is a common occurrence among pre-term infants and can lead to severe complications if not addressed. Objective: To determine the prevalence of hyperbilirubinemia in preterm neonates admitted to the nursery of Mufti Mehmood Hospital, Gomal Medical College, D.I Khan. Methods: This descriptive cross-sectional study was conducted from 10 October 2024 to 10 March 2025 in the Department of Pediatric Medicine, Mufti Mehmood Hospital, Gomal Medical College, D.I Khan. A total of 96 preterm neonates admitted within 7 days of birth were included. Serum bilirubin level more than 5 mg/dL with visible jaundice was taken as hyperbilirubinemia. Data were analysed using the Statistical Package for the Social Sciences version 26. Stratification was performed, and the chi-square test and Fisher's exact test were applied. P-value ≤0.05 was considered significant. Results: Mean age was 4.14 ± 1.54 days, and mean gestational age was 32.17 ± 2.74 weeks. Hyperbilirubinemia was present in 48 (50%). Significant associations were found with age ≤4 days (69.6%, p<0.001), male gender (63.3%, p=0.008), gestational age ≤32 weeks (100%, p<0.001), and birth weight ≤2000 grams (100%, p<0.001). Conclusion: Hyperbilirubinemia is very common in preterm neonates. Lower gestational age and low birth weight are strongly related to this condition.
Downloads
References
Morniroli D, Tiraferri V, Maiocco G, De Rose DU, Cresi F, Coscia A, et al. Beyond survival: the lasting effects of premature birth. Front Pediatr. 2023;11:1213243. https://doi.org/10.3389/fped.2023.1213243
de Paula ICSF, Dos Santos CS, Werneck RI, de Araujo CM, Rodrigues ÁOLJ, Mendes AL, et al. Global prevalence of neonatal mortality in preterm infants: a systematic review and meta-analysis. BMC Pregnancy Childbirth. 2025;25(1):1316. https://doi.org/10.1186/s12884-025-08490-3
Jang KB, Seo E, Kim Y. Dynamic interactions between the gut microbiome, health, and metabolic disorders in preterm infants. J Microbiol Biotechnol. 2025;35:e2508033. https://doi.org/10.4014/jmb.2508.08033
Reiss JD, Mataraso SJ, Holzapfel LF, Marić I, Kasowski MM, Martin CR, et al. Applications of metabolomics and lipidomics in the neonatal intensive care unit. Neoreviews. 2025;26(2):e100-e114. https://doi.org/10.1542/neo.26-2-011
Gedefaw GD, Abuhay AG, Daka DT, Wondie WT, Gonete AT, Getaneh FB, et al. Time to recovery and its predictors among neonates undergoing phototherapy at the comprehensive specialised hospitals of northwest Ethiopia. Sci Rep. 2024;14(1):31665. https://doi.org/10.1038/s41598-024-80964-4
Safo-Mensah N, Amfo-Swanzy O, Ashong J, Okai E, Amoako MF, Lomotey P, et al. Determinants of jaundice severity in neonates admitted at a teaching hospital in Ghana. PLoS One. 2025;20(6):e0325003. https://doi.org/10.1371/journal.pone.0325003
Hanafusa H, Abe S, Ohyama S, Kyono Y, Kido T, Nakasone R, et al. Influence of UGT1A1 genetic variants on free bilirubin levels in Japanese newborns: a preliminary study. Int J Environ Res Public Health. 2022;19(20):13090. DOI: https://doi.org/10.3390/ijerph192013090
Thielemans L, Peerawaranun P, Mukaka M, Paw MK, Wiladphaingern J, Landier J, et al. High levels of pathological jaundice in the first 24 hours and neonatal hyperbilirubinaemia in an epidemiological cohort study on the Thailand-Myanmar border. PLoS One. 2021;16(10):e0258127. https://doi.org/10.1371/journal.pone.0258127
Mishra S, Wanare H. Hierarchical decision model for in vitro bilirubin content prediction from absorption spectrum of whole blood. J Biomed Opt. 2023;28(6):067001. https://doi.org/10.1117/1.JBO.28.6.067001
Ghobrial EE, Al Sayed HM, Saher AEM, Mahmoud BER. Neonatal jaundice: magnitude of the problem in Cairo University’s neonatal intensive care unit as a referral centre. Afr Health Sci. 2023;23(1):656-666. DOI: https://doi.org/10.4314/ahs.v23i1.70
van der Geest BAM, de Mol MJS, Barendse ISA, de Graaf JP, Bertens LCM, Poley MJ, et al. Assessment, management, and incidence of neonatal jaundice in healthy neonates cared for in primary care: a prospective cohort study. Sci Rep. 2022;12(1):14385. https://doi.org/10.1038/s41598-022-17933-2
Choi Y, Park S, Lee H. Neonatal jaundice requiring phototherapy risk factors in a newborn nursery: machine learning approach. Children (Basel). 2025;12(8):1020. https://doi.org/10.3390/children12081020
Uchida Y, Takahashi Y, Kurata C, Morimoto Y, Ohtani E, Tosaki A, et al. Urinary lumirubin excretion in jaundiced preterm neonates during phototherapy with blue light-emitting diode vs green fluorescent lamp. Sci Rep. 2023;13(1):18359. https://doi.org/10.1038/s41598-023-45147-7
Hemmati F, Mahini SM, Bushehri M, Asadi AH, Barzegar H. Exchange transfusion trends and risk factors for extreme neonatal hyperbilirubinemia over 10 years in Shiraz, Iran. Iran J Med Sci. 2024;49(6):384-393. https://doi.org/10.30476/ijms.2023.99176.3123
Aynalem S, Abayneh M, Metaferia G, Demissie AG, Gidi NW, Demtse AG, et al. Hyperbilirubinemia in preterm infants admitted to neonatal intensive care units in Ethiopia. Glob Pediatr Health. 2020;7:2333794X20985809.
Creeden JF, Gordon DM, Stec DE, Hinds TD Jr. Bilirubin as a metabolic hormone: the physiological relevance of low levels. Am J Physiol Endocrinol Metab. 2021;320(2):E191-E207. https://doi.org/10.1152/ajpendo.00405.2020
Asaye S, Bekele M, Getachew A, Fufa D, Adugna T, Tadese E. Hyperbilirubinemia and associated factors among neonates admitted to the neonatal care unit in Jimma Medical Centre. Research Square. 2022. DOI: https://doi.org/10.21203/rs.3.rs-1808478/v1
Kabyemera R, Mumwi M, Rwezaula R, Kidenya B, Hokororo A. Prevalence and factors associated with hyperbilirubinemia and the utility of transcutaneous bilirubin among neonates admitted to Bugando Medical Centre, Mwanza, Tanzania. Journal of African Neonatal. 2025;1:1-8.
Kukkadapu S, Tumma UK. Prevalence of neonatal hyperbilirubinemia in low birth weight and normal birth weight babies. International Journal of Current Pharmaceutical Review and Research. 2025;17(10):822-826. https://doi.org/10.22159/ijcpr.2025v17i10.137
Salman M, Rathore H, Ariff S, Ali R, Khan AA, Nasir M. Frequency of immediate neonatal complications (hypoglycemia and neonatal jaundice) in late preterm and term neonates. Cureus. 2021;13(1):e12512. https://doi.org/10.7759/cureus.12512
Sindhu, Naz F, Kumar M, Raza A, Usman M, Lohana M. Prevalence and factors associated with significant rebound hyperbilirubinemia after phototherapy among neonates: a cross-sectional survey. Pakistan Journal of Medical and Health Sciences. 2022;16(11):552-554.
Gasmelseed SAA, Magzoub OS, Aledresi MAAA. Prevalent causes and outcomes of unconjugated hyperbilirubinemia in neonates. World Journal of Advanced Research and Reviews. 2025;27(02):1465-1473. https://doi.org/10.30574/wjarr
Rauf S, Salah-ud-Din B, Abbas G, Nawaz Z. Incidence and risk factors of acute bilirubin encephalopathy in neonates with hyperbilirubinemia presenting at secondary care hospital. Pakistan Journal of Medical Sciences. 2023;39(2):583-586. https://doi.org/10.12669/pjms.39.2.5520
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2025 Sulaiman Khan, Taj Muhammad

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.



