Effect of Platelet-Rich Fibrin on Wound Healing and Bone Regeneration Following Mandibular Molar Extraction

Muhammad Hamza  Mujeeb; Noor Ul Ain  Arshad; Fatima  Aziz; Usman  Manzoor; Ayesha  Ramzan; Awais  Khar

doi:10.54112/bcsrj.v6i4.1699

Authors

Muhammad Hamza Mujeeb Department of Oral and Maxillofacial Surgery, Ibn e Siena hospital and Research Institute Multan, Pakistan
Noor Ul Ain Arshad Department of Oral and Maxillofacial Surgery, Ibn e Siena hospital and Research Institute Multan, Pakistan
Fatima Aziz Department of Oral and Maxillofacial Surgery, Ibn e Siena hospital and Research Institute Multan, Pakistan
Usman Manzoor Department of Oral and Maxillofacial Surgery, Ibn e Siena hospital and Research Institute Multan, Pakistan
Ayesha Ramzan Department of Oral and Maxillofacial Surgery, Ibn e Siena hospital and Research Institute Multan, Pakistan
Awais Khar Department of Oral and Maxillofacial Surgery, Ibn e Siena hospital and Research Institute Multan, Pakistan

DOI:

https://doi.org/10.54112/bcsrj.v6i4.1699

Keywords:

Platelet-rich fibrin, wound healing, bone regeneration, mandibular molar extraction, autologous biomaterial

Abstract

Mandibular molar extractions are often accompanied by significant soft tissue and alveolar bone loss, complicating future prosthodontic rehabilitation. Platelet-rich fibrin (PRF), an autologous biomaterial, has demonstrated regenerative potential; however, its efficacy in posterior mandibular sockets remains underexplored. Objective: To evaluate the effect of PRF on soft tissue healing and bone regeneration following mandibular molar extraction using standardized clinical and radiographic parameters. Methods: This prospective, randomized controlled trial was conducted at the Ibn e Siena hospital and Research Institute Multan, between June and December 2024. Sixty patients requiring mandibular molar extraction were randomly allocated to receive either PRF application or natural healing (control). Soft tissue healing was assessed using the Landry index at days 7 and 14. Bone regeneration was evaluated at 8 weeks using intraoral periapical radiographs, with bone fill percentage and bone density (HU) analyzed via ImageJ. Statistical analysis was performed using SPSS v25, with p<0.05 considered significant. Results: The PRF group showed significantly improved soft tissue healing at day 7 (76.7% vs. 43.3%, p=0.004) and day 14 (90% vs. 60%, p=0.001) compared to controls. At 8 weeks, bone fill was significantly higher in the PRF group (72.3 ± 6.2%) versus control (58.5 ± 7.4%, p<0.001), along with greater bone density (412 ± 35 HU vs. 326 ± 40 HU, p<0.001). PRF also reduced postoperative complications (3.3% vs. 20%, p=0.03), with dry socket observed only in the control group (13.3%, p=0.04). Conclusion: PRF significantly enhances soft tissue healing, bone regeneration, and reduces complications following mandibular molar extractions. Its autologous nature, cost-effectiveness, and simplicity make it a valuable adjunct in oral surgical procedures, especially in resource-limited settings.

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