Immunization Status of Children Admitted With Measles in a Tertiary Care Hospital

Aqsa  Haider; Kehkashan  Humayun; Saima  Moiz; Ramsha  Ali; Hira  Mujeeb; Fatima  Ali

doi:10.54112/bcsrj.v6i4.1661

Authors

Aqsa Haider Department of Pediatrics, Patel Hospital Karachi, Pakistan
Kehkashan Humayun Department of Pediatrics, Patel Hospital Karachi, Pakistan
Saima Moiz Department of Pediatrics, Patel Hospital Karachi, Pakistan
Ramsha Ali Department of Pediatrics, Patel Hospital Karachi, Pakistan
Hira Mujeeb Department of Pediatrics, Patel Hospital Karachi, Pakistan
Fatima Ali Department of Pediatrics, Patel Hospital Karachi, Pakistan

DOI:

https://doi.org/10.54112/bcsrj.v6i4.1661

Keywords:

Measles Immunization Pediatrics, Vaccination Coverage, Socioeconomic Factors

Abstract

Measles continues to pose a pervasive threat in pediatric healthcare, as it not only has a high rate of transmissibility but also has the potential to lead to severe complications such as pneumonia and encephalitis. Objective: To determine the immunization status of children presenting with measles at a tertiary care hospital. Methods: This Cross-Sectional study design was conducted at the Dept of Pediatrics – Patel Hospital, Karachi, during July 2024 to December 2024. Ethical approval was secured from the Institutional Review Board of the designated tertiary care hospital before data collection began. Pediatric patients admitted with measles were identified and enrolled as study participants after obtaining informed consent from their guardians or parents. Data were gathered using a structured questionnaire designed to capture sociodemographic details, disease history, clinical symptoms, and immunization status. Results: Data were collected from 261 children with a majority being male (59.77%). The mean age was 4.6 years (±2.3). Socioeconomic distribution showed that most participants belonged to low-income families (65%), while middle-income (22%) and high-income (13%) families had lower representation. Regarding parental education, 58% of parents had no formal education, 27% had primary education, and only 15% had secondary or higher education, highlighting educational disparities among the participants' families. Conclusion: It is concluded that immunization plays a critical role in preventing measles and reducing its complications, with fully vaccinated children experiencing significantly lower rates of severe outcomes compared to unvaccinated ones.

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References

Aurangzeb B, Fatmee A, Waris R, Haider N, Berjees A, Raza SH. Risk factors for mortality among admitted children with complications of measles in Pakistan: An observational study. J Pak Med Assoc. 2021;71(2(a)):497-501.

Muhammad A, Irshad M, Khan BJJoPMI. A comparative study of measles complications in vaccinated versus non-vaccinated children. 2011;25(1).

Paules CI, Marston HD, Fauci AS. Measles in 2019 - Going Backward. N Engl J Med. 2019;380(23):2185-7.

Zahoor MA, Rasool MH, Waseem M, Aslam B, Zahoor MK, Saqalein M, et al. Prevalence of measles in vaccinated and non-vaccinated children. 2015;14:504.

Ameer M, Aziz S, Ehsan S, Kulsoom UJAOASH, MEDICAL K, COLLEGE D. Frequency of Immunisation Status, Complications and Outcome in Children Admitted with Measles in Public and Private Sector Hospitals of Karachi. 2018;23(1):21-8.

Liu CP, Lu HP, Luor T. Observational study of a new strategy and management policy for measles prevention in medical personnel in a hospital setting. BMC Infect Dis. 2019;19(1):551.

Dixon MG, Ferrari M, Antoni S, Li X, Portnoy A, Lambert B, et al. Progress Toward Regional Measles Elimination - Worldwide, 2000-2020. MMWR Morb Mortal Wkly Rep. 2021;70(45):1563-9.

Thakkar N, Gilani SSA, Hasan Q, McCarthy KA. Decreasing the measles burden by optimizing campaign timing. Proc Natl Acad Sci U S A. 2019;116(22):11069-73.

Organization where. Measles web Dec 5, 2019 (cited 5 December 2019). Available from: https://www.who.int/news-room/fact-sheets/detail/measles# #.

ORGANIZATION WH. UNICEF and WHO warn of a perfect storm of conditions for measles outbreaks, affecting children in 2022 (Available from: www.who.int/news/item/27-04-2022-unicef-and-who-warn-of--perfect-storm-of-conditions-for-measles-outbreaks--affecting-children).

Rashid MA, Afridi MI, Your Rehman MAJGJoMS. Frequency of complications in measles patients at Peshawar. 2016;14(2).

Rana MS, Alam MM, Ikram A, Salman M, Mere MO, Usman M, et al. Emergence of measles during the COVID-19 pandemic threatens Pakistan's children and the wider region. 2021;27(7):1127-8.

Hickman CJ, Hyde TB, Sowers SB, Mercader S, McGrew M, Williams NJ, et al. Laboratory characterization of measles virus infection in previously vaccinated and unvaccinated individuals. J Infect Dis. 2011;204 Suppl 1:S549-58.

Younas S, Rehman HU, Saleem A, Walayat B, Naveed SA, Usman B, et al. Measles virus outbreak in the district of Karak, KP, Pakistan. JEZS. 2017;5:1655–61. Available from: http://www.entomoljournal.com/archives/?year=2017&vol=5&issue=4&part=V&ArticleId=2251. Accessed 21 January 2018.

Davoodian P, Atashabparwar A, Dadvand H, Hosseinpour M, Daryanavard A, Safari R, et al. A report of outbreak of measles on the southern coast of Iran from 2009 to 2015. Electron Physician. 2017;9:3997–4002. doi:10.19082/3997.

Faneye AO, Adeniji JA, Olusola BA, Motayo BO, Akintunde GB. Measles virus infection among vaccinated and unvaccinated children in Nigeria. Viral Immunol. 2015;28:304–8. doi:10.1089/vim.2014.0118.

Leuridan E, Hens N, Hutse V, Leven M, Aerts M, Van Damme P. Early waning of maternal measles antibodies in the era of measles elimination: a longitudinal study. BMJ. 2010;340:c1626. doi:10.1136/bmj.c1626.

Waaijenborg S, Hahne S, Mollema L, Smits GP, Berbers GA, van der Klis FR, et al. Waning of maternal antibodies against measles, rubella, and varicella in communities with contrasting vaccination coverage. J Infect Dis. 2013;208:10 60. doi:10.1093/infdis/jit143.