Comparative Study on the Effect of Zinc and Probiotic Therapy Versus Zinc Supplementation Alone on the Duration of Acute Watery Diarrhea in Children

Authors

  • Maryam Mateen Department of Pediatrics, Sughra Shafi Medical Complex Narowal, Pakistan
  • Emran Roshan Department of Pediatrics, Sughra Shafi Medical Complex Narowal, Pakistan
  • Muhammad khizar hayyat Department of Pediatrics, Sughra Shafi Medical Complex Narowal, Pakistan
  • Abdul Rehman Akram Department of Pediatrics, Sughra Shafi Medical Complex Narowal, Pakistan
  • Tahira Nasrin Department of Obstetrics and Gynaecology, Services Hospital Lahore, Pakistan
  • Saad Bakhtawar Khan Department of Pulmonology, Mayo Hospital Lahore, Pakistan

DOI:

https://doi.org/10.54112/bcsrj.v6i2.1565

Keywords:

Acute Watery Diarrhea, Zinc Supplementation, Probiotics.

Abstract

Diarrhea remains a leading cause of morbidity and mortality among children worldwide. Numerous studies have investigated the effects of zinc and probiotics in reducing the duration and severity of acute watery diarrhea. Objective: This study aimed to compare the efficacy of zinc-probiotic combination therapy with zinc-only therapy in managing acute watery diarrhea in pediatric patients. Methodology: Conducted at the Department of Pediatrics, Sughra Shafi Medical Complex, Narowal, from March 10, 2023, to August 10, 2024, the study enrolled 80 children diagnosed with acute watery diarrhea, who were randomly assigned into two groups. Group A received oral zinc, low osmolarity ORS, and continued nutritious feeding, while Group B was given Enflor sachets in addition to zinc and ORS. The duration of diarrhea was recorded, and data analysis was performed using SPSS v25.0. A t-test was used to compare the duration of diarrhea between the two groups, with statistical significance set at p ≤ 0.05. Results: The average age in Group A was 38.3±10.5 months, and in Group B, it was 38.6±10.1 months. The duration of diarrhea in Group A was 31.35±2.338 hours, compared to 24.08±2.495 hours in Group B, with a significant difference (p = 0.0001). Conclusion: The combination of probiotics and zinc was more effective than zinc alone in reducing the duration of acute diarrhea in children, suggesting a significant improvement in treatment outcomes.

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References

Noghanibehambari H, Noghani F, Tavassoli N. Child support enforcement and child mortality. Applied economics letters. 2022;29(5):391-402.

Sharrow D, Hug L, You D, Alkema L, Black R, Cousens S, et al. Global, regional, and national trends in under-5 mortality between 1990 and 2019 with scenario-based projections until 2030: a systematic analysis by the UN Inter-agency Group for Child Mortality Estimation. The Lancet Global Health. 2022;10(2):195-206.

GBD 2019 Ageing Collaborators. Global, regional, and national burden of diseases and injuries for adults 70 years and older: systematic analysis for the Global Burden of Disease 2019 Study. bmj. 2022;376.

Florez ID, Nino-Serna LF, Beltran-Arroyave CP. Acute infectious diarrhea and gastroenteritis in children. Current infectious disease reports. 2020;22:1-2.

Dhingra U, Kisenge R, Sudfeld CR, Dhingra P, Somji S, Dutta A, Bakari M, Deb S, Devi P, Liu E, Chauhan A. Lower-dose zinc for childhood diarrhea—A randomized, multicenter trial. New England Journal of Medicine. 2020;383(13):1231-41.

Putri WB, Akhmad SA, Desrini S. The role of zinc supplementation for diarrhoea in children: a critical review. Bangladesh Journal of Medical Science. 2019;18(2):190.

Rerksuppaphol L, Rerksuppaphol S. Efficacy of zinc supplementation in the management of acute diarrhoea: a randomised controlled trial. Paediatrics and International Child Health. 2020;40(2):105-10.

Kaźmierczak-Siedlecka K, Ruszkowski J, Fic M, Folwarski M, Makarewicz W. Saccharomyces boulardii CNCM I-745: A non-bacterial microorganism used as probiotic agent in supporting treatment of selected diseases. Current microbiology. 2020:1987-96.

Altcheh J, Carosella MV, Ceballos A, D’Andrea U, Jofre SM, Marotta C, Mugeri D, Sabbaj L, Soto A, Josse C, Montestruc F. Randomized, direct comparison study of Saccharomyces boulardii CNCM I-745 versus multi-strained Bacillus clausii probiotics for the treatment of pediatric acute gastroenteritis. Medicine. 2022;101(36):25-35.

Kakar Z, Essazai AB, Ahmed SM, Ullah N, Jan P. Comparison of Zinc-Probiotic Combination Therapy to Probiotic Therapy Alone in Treating Acute Diarrhea in Children. Pakistan Journal of Medical & Health Sciences. 2022;16(12):253-5.

Hatta M, Supriatmo S, Ali M, Sinuhaji AB, Hasibuan B, Nasution FL. Comparison of zinc-probiotic combination therapy to zinc therapy alone in reducing the severity of acute diarrhea. Paediatrica Indonesiana. 2011;51(1):1-6.

Nikhurpa M, Agnihotri R. A Comparative Evaluation on the effect of Zinc-Probiotic combination versus Zinc alone therapy in children (3month-5year) with acute watery diarrhea attending the outpatient clinic of Sub-District hospital, Uttarakhand. Int J Med Res Rev. 2021;9(4):263-268.

GBD 2016 Diarrhoeal Disease Collaborators. Estimates of the global, regional, and national morbidity, mortality, and aetiologies of diarrhoea in 195 countries: a systematic analysis for the Global Burden of Disease Study 2016. Lancet Infect Dis. 2018;18(11):1211-1228.

Mokomane M, Kasvosve I, de Melo E, Pernica JM, Goldfarb DM. The global problem of childhood diarrhoeal diseases: emerging strategies in prevention and management. Ther Adv Infect Dis. 2018;5(1):29-43.

Viegelmann GC, Dorji J, Guo X, Lim HY. Approach to diarrhoeal disorders in children. Singapore Med J. 2021;62(12):623-629.

Wessells KR, Brown KH. Estimating the global prevalence of zinc deficiency: results based on zinc availability in national food supplies and the prevalence of stunting. PLOS ONE 2012;7(11):e50568.

International Zinc Nutrition Consultative Group (IZiNCG), Hotz C, Brown KH, editor(s). Assessment of the risk of zinc deficiency in population and options for its control. Food Nutr Bulletin. 2004;25(1-2):91–202.

Mayo-Wilson E, Imdad A, Junior J, Dean S, Bhutta ZA. Preventive zinc supplementation for children, and the effect of additional iron: a systematic review and meta-analysis. BMJ Open. 2014;4(6):e004647.

Bairwa M, Rajput M, Sachdeva S. Modified Kuppuswamy’s socioeconomic scale: social researcher should include updated income criteria, 2012. Indian JCommunity Med. 2013;38(3):185-9.

Guarino A, Guandalini S, Vecchio AL. Probiotics for prevention and treatment of diarrhea. J Clin Gastroenterol. 2015;49:S37-45.

Azim MA, Doza B, Iqbal S, Chowdhury F, Biswas SK. Comparative Evaluation on the Effect of Zinc-Probiotic and Zinc Therapy in Pediatric Acute Gastroenteritis. Chattagram Maa-O-Shishu Hospital Med Coll J. 2020;19;1:74-77.

Nguyen TV, Le Van P, Le Huy C, Weintraub A. Diarrhea caused by rotavirus in children less than 5 years of age in Hanoi, Vietnam. J Clin Microbiol. 2004;42(12):5745-50.

Szajewska H, Mrukowicz JZ. Probiotics in the treatment and prevention of acute infectious diarrhoea in infants and children; a systematic review of published randomized, double‐blind, placebo‐controlled trials. J Pediatr Gastroenterol Nutr. 2001;33(2):17‐25.

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Published

2025-02-28

How to Cite

Mateen, M. ., Roshan, E., hayyat, M. khizar, Rehman Akram, A. ., Nasrin, T. ., & Bakhtawar Khan, S. (2025). Comparative Study on the Effect of Zinc and Probiotic Therapy Versus Zinc Supplementation Alone on the Duration of Acute Watery Diarrhea in Children. Biological and Clinical Sciences Research Journal, 6(2), 64–68. https://doi.org/10.54112/bcsrj.v6i2.1565

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Original Research Articles