Biological and Clinical Sciences Research Journal
ISSN: 2708-2261
www.bcsrj.com
DOI: https://doi.org/10.47264/bcsrj0101030
Biol. Clin. Sci. Res. J., Volume, 2020:
e030
Review Article
THE EPIDEMICS OF COVID-19
¥SIDDIQUE A, ¥FATEH
A, ¥IDREES N, *HAFEEZ MM, *ALI Q, MALIK A
Institute of Molecular Biology
and Biotechnology, The University of Lahore, Lahore, Pakistan
¥Authors contributed equally
Corresponding
author email: saim1692@gmail.com, mansoorhafeez140@gmail.com
Abstract
Due
to modernization and industrialization the whole world population is under the
threat of new diseases. With the passage of every day even every moment the
diseases are taking the world by large. Recently, there is a new public health
issue which started from China and has raised the eyebrow of the whole world
population. The reversal and modified coronavirus, known as novel coronavirus
leading to acute Respiratory syndrome coronavirus, (SAR-CoV-2) is causing
deaths throughout the world. This Virus has been originated and usually found
in bats with an ability to be transmitted to humans or animals through various unknown
intermediate vectors from Wuhan, The Hubei Province of China ( December 2019).
This virus has been named as COVID-19, which spread through inhalation or even
through contacting with the infected person. The survival and the incubation
period of this virus have been found to be ranged from 2-14days. Most one of
the three people suffering are found to be asymptomatic, act as carrier and
they are source of transmitting it to the healthy people. The disease has been
found to be remained mild in most of the people with symptoms which are usually
in the form of cough, fever, fatigue, sore throat, malaise, breathlessness lack
of taste and among others, it may lead to pneumonia, multi-organ dysfunction
and severe respiratory disorders, the fatality rate is 2-3%. It can be
diagnosed by respiratory secretion through molecular test. The tomographic scan
of chest has been found abnormal in most of cases, even among those patients
who have been suffered with mild or no symptoms. Antiviral agents are being
used in treating the disease due to lack of solid medicine in the market. It
has been recommended to isolate the person with mild, severe of chronic
symptoms and to take possible precautionary measures as the virus spread faster
than its two previous strains as SAR CoV and Middle East Respiratory syndrome
coronavirus (MER-CoV) which had low fatality rate.
Keywords: Tomographic
chest scan, SAR-CoV-2, MERS-CoV, CoVID-19, fatality
Introduction
The severe acute respiratory syndrome corona
virus-2 (SAR -CoV) has been know as a modified form or novel coronavirus
firstly introduced and started rapidly spreading from within the city of Hubei
province of China to the rest of world (COVID and Team, 2020; Fauci et al., 2020; Nishiura
et al., 2020).
The USA register 86,000 cases, including fewer than 800, Recoveries 1,300 have
died so far in the country till (27-7-20), while now currently there are around
6, 943,461 (Table 1) registered cases in USA including 203,455 deaths with
4,194,597 total recovered from this disease. Now India has been found the most
affected country with respect to daily registered patients, currently India has
5,351,723 cases including 86,043 deaths with 4,249,648 recovered from disease
(dated 18-09-2020). Fortunately, it has been reported that the children are
less effective with it due to their strong immunity.
There is a need to seek knowledge from
articles and news to updates our self regularly.
Table 1
Top ten countries for cases, death, recovered and active cases of COVID-19
Countries |
Cases |
Deaths |
Recovered |
Active cases |
USA |
6,943,527 |
203,455 |
4,194,597 |
2,545,475 |
India |
5,351,723 |
86,043 |
4,249,648 |
1,016,032 |
Brazil |
4,503,002 |
136,035 |
3,789,139 |
577,828 |
Russia |
1,097,251 |
19,339 |
906,462 |
171,450 |
Peru |
756,412 |
31,283 |
600,795 |
124,334 |
Colombia |
750,471 |
23,850 |
621,521 |
105,100 |
Mexico |
688,954 |
72,803 |
492,192 |
123,959 |
Spain |
659,334 |
30,495 |
N/A |
N/A |
South Africa |
657,627 |
15,857 |
586,844 |
54,926 |
Argentina |
613,658 |
12,705 |
N/A |
N/A |
History
Four types of coronavirus have been
discovered named as HKUI, Nl63, 229E and OC43 Beta coronavirus exists among
past years causing severe disease in animals and then to humans in 2002-2003, of
B-genera derived from bats, passed over to humans by a host of palm civet in the
Guangdong one of China province, causing the severe respiratory syndrome (Clerkin et al., 2020; Zu et al., 2020).
Decades later the East respiratory syndrome coronavirus named as MERS-CoV has
been also found to be derived from bats, which was emerged in Saudia Arabia (Organization, 2020; Remuzzi and Remuzzi, 2020).
Origin and the spread of COVID -19
During the last
month of 2019, the adults from the Hubei city,
province who were using local transportation were diagnosed with severe type of
pneumonia due to unknown cause, after that the initial most cases were found to
be exist in the local market of seafood, had been sealed by government (The
surveillance system output in areas after the SARs outbreak) gets highly activated
while the samples of patients for diagnose were sent to specified medical labs,
for the etiological investigations of disease (Velavan and Meyer,
2020; Yi et al., 2020).
The market was closed, later on, it has found more than 95% homology with
coronavirus found in bates while more than 70% of similarities were found with SAR-CoV,
then a samples taken from Sea-food and environmental air drops were also tested
as positive for COVID-19, indicating that it may be a source of spreading by
the person who comes with exposure to environment droplets or humans infected
with this virus (Croda et al., 2020; Pei et al., 2020; Wang
et al., 2020).
The very first initial case which was
reported on 11thJan 2020 as there was a huge in sense of number
migration was followed during that time as it was Chinese New year which fueled
the epidemic, later on, the cases from other countries were also reported lied at
boarder line as well as the far countries
from China (Dhama et al., 2020; Schwartz et al., 2020).
After the identification of cases in China there was lockdown of the Hubei
Province for rest of the period until the complete end or removal of disease
from population of the Province. It was found to be a risk for healthy people
that’s why there was onward lockdown with restrictions of entry and exit was
applied to that region. Airports in the different region including India and
Pakistan put in screening Mechanism and put all of them under observation to
those returning from China for 14 days (Kandeel et al., 2020; Tu et al., 2020).
Soon it appears that COVID -19 could be transmitted from asymptomatic people
before the onset of symptoms so all were isolated for 14 days from airports to
retest them later on using precautionary measures it decrease in china start increasing in countries like including
Iran, Italy and South Korea. In spite that the (SAR -CoV-2) begin originated from
bats however it transverse to people is questionable, the pangolin and snakes
are still know as current suspects (Diao et al., 2020; Montalvan et al., 2020; Paoli
et al., 2020).
Epidemiology and the pathogenesis
The population around the world of all age
groups has been found susceptible. The infection has been found to be transmitted
through the huge globules produced while hacking and wheezing by acute corona patients,
at any rate, may be correspondingly happen from an asymptomatic individual and also
before the start of the reaction. There have been several studies which have
demonstrated higher corona viral weight in nasal hole when contrasted with the
throat of no distinction in viral weight among most of the suggestive and
patients with asymptomatic conditions (Contini et al., 2020; Montalvan et al., 2020).
The some of the patients have been found to be stronger in sense of immune system
for whatever timeframe that the symptoms continue onward and even on the clinical
recovery of patients. The infection can stay reasonable on surfaces for a
considerable length of time in favorable climatic conditions yet are decimated
in under a moment by basic disinfectants like sodium hypochlorite, hydrogen
peroxide, and so forth (Grech, 2020; Jouzdani, 2020; Saadat
et al., 2020).
The disease has been found to be acquired either by the internal breath of
these dots or reaching surfaces polluted by them and a short time later
reaching the mouth, nose and eyes. The contamination is moreover present in the
stool and soiling of water deftly and coming about transmission through
fecal-oral course is furthermore speculated (Pastor, 2020; Pozzilli and Lenzi, 2020).
According to current data, transplacental transmission from pregnant ladies to
their babies has also been depicted. However, neonatal ailment on account of
postnatal transmission is depicted. The incubating time shift from 2 to 14 d.
Studies have recognized angiotensin receptor 2 (ACE2) as the receptor through
which the contamination enters the respiratory mucosa. The fundamental case
duplication rate (BCR) is surveyed to reach out from 2 to 6.47 in various
exhibiting considers. In assessment, the BCR of SARS was 2 and 1, 3 for
pandemic flu H1N1 2009 (Huarcaya-Victoria,
2020; Jia et al., 2020).
Clinical characteristics
The clinical characteristics of COVID-19 have
been found changed, expanding from asymptomatic form to strongly respiratory
inconvenience and multi organs brokenness. Mild severe side effects may arise
12-14 days after introductions including, fever, chills, muscles or body hurts,
fatigue, cerebral pain, shortness of breath, blockage, runny nose, sickness or
vomiting, and diarrhea. Fever, cough, and weakness are the most common clinical
features a patient with COVID-19 (D’Marco et al., 2020; Jia et al., 2020; Yuan
et al., 2020).
Hence they are unclear from other respiratory infectious diseases, in a subset
of a patient, before the finish of the initial week of the disease which may progress
in to pneumonia, the respiratory frustration. The start of pneumonia and
respiratory problem cause to rise in the
provocative cytokines including the IL2, IL10, IL7, IP10, GCSF, MIP1A, MCP1 and
the TNFα. The average time from the onset of the side effects like dyspnea
were found to be 5d, hospitalization 7days, and intense respiratory trouble
disorder (ARDS) takes 8days (Aziz et al., 2020; Huarcaya-Victoria, 2020). Such patients required intensive care which is up to
25-30% among all of the affected patients throughout the world. There were
large number of complications reported which has been included intense lung
damage, kidney damage, and stun, recuperation begun within the 2nd
and 3rd week (D’Marco et al., 2020; Diao et al., 2020). The middle term of the healing center remains
in those who recuperated within 10days. Unfavorable results and death is the common
within elderly and those with basic co-morbidities which are 50-75% among all
of the deadly cases. Casualty rates in hospitalized grown-up patients have been
extended from 4 to 11%. The general cases casualty rate is evaluated to extend
between 2 to 3% (Clerkin et al., 2020; Contini et al., 2020; Croda
et al., 2020).
Infection neonates, newborn babies, and the children
have also been detailed to be basically in mild cases as compared with their
grown-up partners. An evidence was there in China province Shenzhen where there
were around 34 children who were infected and were under treatment in care
center of Shenzhen during January 19th to February 7th.
Among all f these children there were 14 males while 20 females with average
age of around 11 years. It was found that the case of disease in 8 children was
connected to their family while the remaining 26 children were heaving
infection due to travel from Hubei province of China (Pastor, 2020; Schwartz et al., 2020; Yi
et al., 2020).
The patients were found either as asymptomatic (9%) or a gentle malady. The
foremost common indications were fever in up to 50% while cough in 38% of
patients. All patients were given with a symptomatic treatment which showed
effectiveness and there was no any death reported in all of 34 patients (Chakraborty and Das,
2020; O’Dowd et al., 2020).
Diagnosis
The continuous high fever, shortness of
breath and a patient with history of travel to China or other zones of
determined neighborhood infected countries or contact with patient comparative
travel history or those with affirmed COVID-19 contamination and in some cases
the quiet may have shown the upper respiratory problems, lower respiratory
symptoms (Poyiadji et al.,
2020; Velavan and Meyer, 2020).
To begin with, here we got to the conclusion of the respiratory test
(throat/swab/sputum). Other research facility examinations are including the total
blood diagnose, lymphopenia (a lymphocyte numbers < 1000) has been related
to extreme infection, but procalcitonin levels are ordinary typical (Gardiner et al.,
2020; Mannan and Mannan, 2020).
A high procalcitonin level may demonstrate a bacterial co-infection.
Nonspecific marker of irritation is C- reactive protein, erythrocytes
sedimentation rate, IL-6, D-dimer, LDL mostly increased. High motility due to
high troponin, CK-MB (creatine kinase-MB) by doing chest X-rays you might see lungs
infection level. For the more delicate test, we go for a CT scans which to check
the lungs shape and colour, a few regions of combination (Corona et al., 2020; Faiq et al., 2020; Mohammed
et al., 2020).
Differential Diagnosis
The differential conclusion incorporates a
wide range of viral infections (influenza, parainfluenza, human
metapneumovirus, adenovirus, non-COVID-19). It is over the top to hope to
isolate COVID-19 from these aliments clinically or through a routine lab test. The
travel history of patients provided enormous information about the
infectiveness due to COVID-19 (Campos et al., 2020; Ray et al., 2020; Shams
et al., 2020).
Treatment
Treatment is permanently or approximately
admiring and symptomatic. In start 1st step is secure sufficiently
isolation to avert transmission of virus other links, patients, friends, healthcare
workers and doctors. The mild illness could be handled at home with guidance
about hazard signals (Gardiner et al.,
2020; Huarcaya-Victoria, 2020). The general principles are including the hydration, asservating,
nutrition and commanding continuous cough and higher fever. Daily use of antiviral
and antibiotics such as oseltamivir could be the nullified drug in all of the
active cases of corona virus. In the hypoxic patients of COVID-19, the movement
of oxygen through the nasal prongs, high flow nasal cannula (HFNC), facemask or
the non-invasive oxygen availability has also been affected (Kandeel et al., 2020; Nishiura et al., 2020; Paoli
et al., 2020).
The mechanical oxygen availability and even the extra cellular membranous
oxygen concentration availability have to be maintained. The renal replacement
therapy may also be needed along with some of the antifungal and antibiotics which
are essential if there are co-infections in kidneys and blood of the patients.
Role of the corticosteroids has been still unproven as the international heath
organizations like WHO has opposed for its use, the Chinese health organization
has given guidelines to urge the short term therapy with low up to the moderate
type of doses for corticosteroids to treat COVID-19 patients. The detailed
guidelines are important for care managements in treating COVID-19 have now been
released time by time through WHO (Organization, 2020; Poyiadji et al., 2020).
However, still there is, no any certified and recommended treatment for
COVID-19 patients. There are some of the antiviral drugs like Lopinavir-ritonavir
and ribavirin have been widely used for treatment of COVID-19 as already have
been used for treating patients of SARD and MERS. During treatment of patients suffering
with SARS, were treated with lopinavir-ritonavir and ribavirin shown better
results in controlling COVID-19 as compared with ribavirin antiviral drug alone
(Saadat et al., 2020; Velavan and Meyer, 2020).
There has been an anecdotal experience for the use of remdeswir as antiviral, a
widespread used anti RNA drug developed for EBOLA virus has been used to treat
COVID-19. However, there is need for evidences before the approval of these
drugs. Some of the drugs which have been proposed for the therapy of COVID-19 are
including arbidol intravenous immunoglobin, interferon, chloroquine and plasma
of patients recovered from COVID-19. Furthermore, the recommendations are there
about using the traditional Chinese herbs which have found their place in
Chinese COVID-19 treatment and control guidelines (Schwartz et al.,
2020; Yuan et al., 2020; Zu
et al., 2020).
Prevention
·
Wash hands daily with soap and water for 20
seconds, and using hand sanitizer of at least 60% alcohol.
·
Put separation among yourself as well as
other people
·
Stop scratching your nose.
·
Maintain strategic distance from close
contact with wiped out individuals.
·
They would be told to cover cough and
sneezes, rather than paws, with tissue papers
·
Wear facemask in case you are wiped out or
thinking about somebody who is debilitated
·
Clean and sanitize surface.
·
Home ventilation should be perfect with
daylight, so that the virus is killed.
·
Human services work force must utilize
individual defensive hardware, for example, N95 covers, outfits and gloves.
·
An applicant antibody is a work in progress.
Coronavirus from
the Islamic point of view
Allah will never hurt us nor does He need shrewdness to
come to pass for us. We may think something is awful for us because of our
confined perspective on life, yet there is in every case great in a circumstance.
At whatever point there is an issue, a test, or any hardship which we can
expel, survive, tackle, or limit, we should do as such. A considerable lot of
the wellbeing rules given by the Ministry of Health are in reality typical
practices for Muslims, some of which are as per the following:
1. Washing hands: this is a piece of bathing, a Muslim's
every day custom of immaculateness.
2. General neatness: The Prophet (ﷺ) said:
"Cleanliness is a piece of confidence". Keeping our environmental
factors clean, tidying up after ourselves, and cleaning surfaces down are on
the whole parts of neatness which must be clung to in these circumstances.
3. Covering your mouth when sniffling; The Prophet would
cover his mouth when he wheezed. This essential can take large part in the
halting of the spread of infections. "At whatever point the Messenger of
Allah (ﷺ) wheezed, he would cover his mouth with his hand or a
bit of material."
4. Isolate in the midst of infections which can spread; The
Prophet gave directions on what to do if there is an episode. Dispatcher of
Allah (ﷺ) state: "On the off chance that you hear that (the
plague) is in a land, don't go there, and on the off chance that it breaks out
in a land where you are, don't leave, escaping from it." And Alhamdulillah
we Kashmiri’s have long periods of lockdown experience.
5. The Prophet (ﷺ) likewise showed
us how to shield ourselves by keeping up our duas from the Sunnah. One such dua
that he showed us was: “In the name of Allah with Whose name nothing can hurt
on earth or in paradise, and He is the All-Hearing, All-Knowing".
6. Being certain and having a hopeful standpoint: Always
have an uplifting viewpoint paying little mind to the circumstance you're in,
this is the thing that our Prophet Muhammad (ﷺ)
educated us.
Conclusion
The recent virus name COVID-19 has not only
challenged. The Chinese frame but its neighboring countries have confronted it.
It’s not anyone else just time which can tell its impact on Indians. Even the
uprising of these micro-organisms of zoonotic origin continues in the same way.
Thus apart from checking these outbreak efforts should be made to plan
comprehensive zoonotic origin.
Conflict
of interest
The authors have declared absence of any type of conflict of
interest.
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